2.50
Hdl Handle:
http://hdl.handle.net/10029/10104
Title:
Benzeen: evaluatie advieswaarde
Authors:
Hesse JM; Kroese ED
Other Titles:
[Benzene: Toxicological limit value.]
Abstract:
A number of recent publications concerning the human risk assessment of benzene was evaluated in order to check if the toxicological limit value derived in the Integrated Criteria Document on benzene (RIVM, 1987) needed to be revised. In the Integrated Criteria Document a non threshold extrapolation method was used, because of the carcinogenic and genotoxic properties of bezene. Using epidemiological data, it was calculated that a concentration of 0,12 mug.m-3 corresponds to a risk of one additional case of leukemia in one million persons exposed for lifetime. The Health Council of the Netherlands subsequently advised to increase this value by two orders of magnitude, because linear non threshold extrapolation would be an overestimation of the actual risk. On the basis of recent studies there is, however, no reason to deviate from the risk assessment approach adopted in the Integrated Criteria Document or to increase the previous derived toxicological limit value.
Affiliation:
ACT; LCM
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
31-Mar-1994
URI:
http://hdl.handle.net/10029/10104
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/601014002.html
Language:
nl
Series/Report no.:
RIVM Rapport 601014002
Appears in Collections:
RIVM reports - old archive

Full metadata record

DC FieldValue Language
dc.contributor.authorHesse JMen_US
dc.contributor.authorKroese EDen_US
dc.date.accessioned2007-03-09T16:37:47Z-
dc.date.available2007-03-09T16:37:47Z-
dc.date.issued1994-03-31en_US
dc.identifier601014002en_US
dc.identifier.urihttp://hdl.handle.net/10029/10104-
dc.description.abstractA number of recent publications concerning the human risk assessment of benzene was evaluated in order to check if the toxicological limit value derived in the Integrated Criteria Document on benzene (RIVM, 1987) needed to be revised. In the Integrated Criteria Document a non threshold extrapolation method was used, because of the carcinogenic and genotoxic properties of bezene. Using epidemiological data, it was calculated that a concentration of 0,12 mug.m-3 corresponds to a risk of one additional case of leukemia in one million persons exposed for lifetime. The Health Council of the Netherlands subsequently advised to increase this value by two orders of magnitude, because linear non threshold extrapolation would be an overestimation of the actual risk. On the basis of recent studies there is, however, no reason to deviate from the risk assessment approach adopted in the Integrated Criteria Document or to increase the previous derived toxicological limit value.en
dc.format.extent869000 bytesen_US
dc.format.extent889485 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isonlen_US
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVMen_US
dc.relation.ispartofseriesRIVM Rapport 601014002en_US
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/601014002.htmlen_US
dc.subject.otherbenzeneen
dc.subject.otherexposureen
dc.subject.othertoxicityen
dc.subject.otherhealth risksen
dc.subject.otherlimitsen
dc.subject.otherevaluation studiesen
dc.subject.otherbenzeennl
dc.subject.otherblootstellingnl
dc.subject.othertoxiciteitnl
dc.subject.otherrisiconl
dc.subject.othergezondheidnl
dc.subject.othergrenswaardenl
dc.subject.otherevaluatienl
dc.titleBenzeen: evaluatie advieswaardeen_US
dc.title.alternative[Benzene: Toxicological limit value.]en_US
dc.contributor.departmentACTen_US
dc.contributor.departmentLCMen_US
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