Lifestyle and cancer of the reproductive organs

2.50
Hdl Handle:
http://hdl.handle.net/10029/10232
Title:
Lifestyle and cancer of the reproductive organs
Authors:
Piersma AH; Spanjersberg MQI; Beekhuijzen MEW
Other Titles:
Leefstijl en kanker van de geslachtsorganen
Abstract:
The incidence of breast cancer, testicular cancer and prostate cancer is increasing in Western societies. Concern has been expressed that human exposure to environmental xenobiotic compounds coupled with endocrine activity may play a role in these cancers, but supporting evidence for the existence of such a relationship is lacking. On the other hand, the twentieth century has seen profound changes in lifestyle, which have undoubtedly influenced the incidence of diseases. This report summarises present knowledge on the relationship between hormone-dependent cancers in humans and lifestyle determinants. Major lifestyle determinants related to reproductive cancer appear to be found in eating and reproductive behaviour. Specific determinants within these areas include caloric intake, physical activity, alcohol consumption, parity, exogenous hormone treatments, sexual activity and hygiene. Dramatic changes in eating patterns in the twentieth century with increased caloric intake in the presence of decreased physical activity, and increased alcohol intake and increased female smoking are thought to have promoted reproductive cancers. In addition, profound changes in reproductive behaviour with decreased parity, increased maternal age, increased sexual activity, wide application of various types of sex hormone therapy and contraceptive measures are thought to have contributed to increased reproductive cancer incidences. Current knowledge on determinants of reproductive cancer suggests that lifestyle determinants may play a more prominent role in determining trends in reproductive cancer incidences than exposure to environmental xenobiotic compounds acting on the endocrine. However, data on human exposure to environmental endocrine-active compounds are needed to allow an analysis of the actual risk of exposure to these compounds in relation to reproductive organ cancer.; De incidenties van borstkanker, testiskanker en prostaatkanker nemen in de westerse wereld toe. Er is sprake van zorg dat blootstelling van de mens aan stoffen in het leefmilieu met endocriene activiteit betrokken zouden kunnen zijn bij deze trends, maar ondersteunend bewijs voor een dergelijke relatie ontbreekt tot dusverere. Anderzijds heeft de twintigste eeuw diepgaande veranderingen in leefstijl te zien gegeven, die ongetwijfeld invloed hebben gehad op de incidenties van ziekten en aandoeningen. Het rapport vat huidige kennis samen omtrent de relatie tussen hormoon-afhankelijke kankers bij de mens en leefstijldeterminanten. Belangrijke leefstijldeterminanten betrokken bij deze kankers worden gevonden op de gebieden van consumptief en sexueel gedrag. Specifieke determinanten daarbinnen zijn calorische inname, lichamelijke activiteit, alcoholconsumptie, kindertal, hormoonmedicatie, sexuele activiteit en hygiene.
Affiliation:
LEO
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
31-Oct-1999
URI:
http://hdl.handle.net/10029/10232
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/650030003.html
Language:
en
Series/Report no.:
RIVM Rapport 650030003
Appears in Collections:
RIVM reports - old archive

Full metadata record

DC FieldValue Language
dc.contributor.authorPiersma AHen_US
dc.contributor.authorSpanjersberg MQIen_US
dc.contributor.authorBeekhuijzen MEWen_US
dc.date.accessioned2007-03-09T16:55:14Z-
dc.date.available2007-03-09T16:55:14Z-
dc.date.issued1999-11-00en_US
dc.identifier650030003en_US
dc.identifier.urihttp://hdl.handle.net/10029/10232-
dc.description.abstractThe incidence of breast cancer, testicular cancer and prostate cancer is increasing in Western societies. Concern has been expressed that human exposure to environmental xenobiotic compounds coupled with endocrine activity may play a role in these cancers, but supporting evidence for the existence of such a relationship is lacking. On the other hand, the twentieth century has seen profound changes in lifestyle, which have undoubtedly influenced the incidence of diseases. This report summarises present knowledge on the relationship between hormone-dependent cancers in humans and lifestyle determinants. Major lifestyle determinants related to reproductive cancer appear to be found in eating and reproductive behaviour. Specific determinants within these areas include caloric intake, physical activity, alcohol consumption, parity, exogenous hormone treatments, sexual activity and hygiene. Dramatic changes in eating patterns in the twentieth century with increased caloric intake in the presence of decreased physical activity, and increased alcohol intake and increased female smoking are thought to have promoted reproductive cancers. In addition, profound changes in reproductive behaviour with decreased parity, increased maternal age, increased sexual activity, wide application of various types of sex hormone therapy and contraceptive measures are thought to have contributed to increased reproductive cancer incidences. Current knowledge on determinants of reproductive cancer suggests that lifestyle determinants may play a more prominent role in determining trends in reproductive cancer incidences than exposure to environmental xenobiotic compounds acting on the endocrine. However, data on human exposure to environmental endocrine-active compounds are needed to allow an analysis of the actual risk of exposure to these compounds in relation to reproductive organ cancer.en
dc.description.abstractDe incidenties van borstkanker, testiskanker en prostaatkanker nemen in de westerse wereld toe. Er is sprake van zorg dat blootstelling van de mens aan stoffen in het leefmilieu met endocriene activiteit betrokken zouden kunnen zijn bij deze trends, maar ondersteunend bewijs voor een dergelijke relatie ontbreekt tot dusverere. Anderzijds heeft de twintigste eeuw diepgaande veranderingen in leefstijl te zien gegeven, die ongetwijfeld invloed hebben gehad op de incidenties van ziekten en aandoeningen. Het rapport vat huidige kennis samen omtrent de relatie tussen hormoon-afhankelijke kankers bij de mens en leefstijldeterminanten. Belangrijke leefstijldeterminanten betrokken bij deze kankers worden gevonden op de gebieden van consumptief en sexueel gedrag. Specifieke determinanten daarbinnen zijn calorische inname, lichamelijke activiteit, alcoholconsumptie, kindertal, hormoonmedicatie, sexuele activiteit en hygiene.nl
dc.format.extent3707000 bytesen_US
dc.format.extent3795699 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen_US
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVMen_US
dc.relation.ispartofseriesRIVM Rapport 650030003en_US
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/650030003.htmlen_US
dc.subject.otherreproductive canceren
dc.subject.otherbreast canceren
dc.subject.otherprostate canceren
dc.subject.othertesticular canceren
dc.subject.otherovarian canceren
dc.subject.othercervical canceren
dc.subject.otherendometrial cnaceren
dc.subject.otherlifestyleen
dc.subject.othernutritionen
dc.subject.othersex hormonesen
dc.subject.otherendocrine disruptorsen
dc.titleLifestyle and cancer of the reproductive organsen_US
dc.title.alternativeLeefstijl en kanker van de geslachtsorganenen_US
dc.contributor.departmentLEOen_US
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