Mutagenic and antimutagenic activities of bioflavonoids and structural analogues in the Ames/Salmonella test

2.50
Hdl Handle:
http://hdl.handle.net/10029/10241
Title:
Mutagenic and antimutagenic activities of bioflavonoids and structural analogues in the Ames/Salmonella test
Authors:
Mohn GR; Van der Stel JJ; Stavenuiter JFC; Hamzink MRJ; Kreijl CF
Other Titles:
Mutagene en antimutagene activiteit van bioflavonoiden en analoge verbindingen in de Ames/Salmonella test
Abstract:
The mutagenic and antimutagenic properties of bioflavonoids were determined in the bacterial mutagenicity test of Ames, using Salmonella typhimurium strains TA98 and TA100. The decreasing order of mutagenic activity found in both strains was quercetin>myricetin-kaempferol>morin hydrate. The compounds galangin, luteolin, apigenin, and chrysin were devoid of mutagenic activity under the present conditions. The antimutagenic activity of the bioflavonoids was measured against the mutagenic activity of benzo(a)pyrene (BaP) in Salmonella strains TA98 and TA100. All compounds investigated, including the compound with the lowest number of hydrozyl side groups and chrysin, did show antimutagenic activity against BaP-induced mutagenesis.; De mutagene en antimutagene eigenschappen van bioflavonoiden werden in de bacteriele mutageniteitstest van Ames met Salmonella typhimurium stammen TA98 en TA100 onderzocht. De volgorde van mutagene activiteit voor beide stammen in aanwezigheid van metabole activering was quercetine>myricetine-kaempferol>morin hydraat. De stoffen galangin, luteoline, apigenine en chrysin vertoonden geen mutagene werking voor Salmonella TA98 en/of TA100. De antimutagene werking van de bioflavonoiden werd bepaald tegen de mutagene werking van benzo(a)pyreen in Salmonella stammen TA98 en TA100. Alle hier onderzochte stoffen, inclusief de stof met het laagst aantal hydroxylgroepen en chrysin vertoonden een antimutagene werking tegen de mutageniteit van benzo(a)pyreen.
Affiliation:
LEO; LBO
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
30-Apr-1996
URI:
http://hdl.handle.net/10029/10241
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/659001004.html
Language:
en
Series/Report no.:
RIVM Rapport 659001004
Appears in Collections:
RIVM reports - old archive

Full metadata record

DC FieldValue Language
dc.contributor.authorMohn GRen_US
dc.contributor.authorVan der Stel JJen_US
dc.contributor.authorStavenuiter JFCen_US
dc.contributor.authorHamzink MRJen_US
dc.contributor.authorKreijl CFen_US
dc.date.accessioned2007-03-09T16:55:36Z-
dc.date.available2007-03-09T16:55:36Z-
dc.date.issued1996-04-30en_US
dc.identifier659001004en_US
dc.identifier.urihttp://hdl.handle.net/10029/10241-
dc.description.abstractThe mutagenic and antimutagenic properties of bioflavonoids were determined in the bacterial mutagenicity test of Ames, using Salmonella typhimurium strains TA98 and TA100. The decreasing order of mutagenic activity found in both strains was quercetin>myricetin-kaempferol>morin hydrate. The compounds galangin, luteolin, apigenin, and chrysin were devoid of mutagenic activity under the present conditions. The antimutagenic activity of the bioflavonoids was measured against the mutagenic activity of benzo(a)pyrene (BaP) in Salmonella strains TA98 and TA100. All compounds investigated, including the compound with the lowest number of hydrozyl side groups and chrysin, did show antimutagenic activity against BaP-induced mutagenesis.en
dc.description.abstractDe mutagene en antimutagene eigenschappen van bioflavonoiden werden in de bacteriele mutageniteitstest van Ames met Salmonella typhimurium stammen TA98 en TA100 onderzocht. De volgorde van mutagene activiteit voor beide stammen in aanwezigheid van metabole activering was quercetine>myricetine-kaempferol>morin hydraat. De stoffen galangin, luteoline, apigenine en chrysin vertoonden geen mutagene werking voor Salmonella TA98 en/of TA100. De antimutagene werking van de bioflavonoiden werd bepaald tegen de mutagene werking van benzo(a)pyreen in Salmonella stammen TA98 en TA100. Alle hier onderzochte stoffen, inclusief de stof met het laagst aantal hydroxylgroepen en chrysin vertoonden een antimutagene werking tegen de mutageniteit van benzo(a)pyreen.nl
dc.format.extent1397000 bytesen_US
dc.format.extent1430128 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen_US
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVMen_US
dc.relation.ispartofseriesRIVM Rapport 659001004en_US
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/659001004.htmlen_US
dc.subject.otherbioflavonoidsen
dc.subject.othermutagenicity testingen
dc.subject.otherantimutagenic agentsen
dc.subject.otherbenzo(a)pyreenen
dc.titleMutagenic and antimutagenic activities of bioflavonoids and structural analogues in the Ames/Salmonella testen_US
dc.title.alternativeMutagene en antimutagene activiteit van bioflavonoiden en analoge verbindingen in de Ames/Salmonella testen_US
dc.contributor.departmentLEOen_US
dc.contributor.departmentLBOen_US
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