Webbased Archive of RIVM Publications >
Articles and other publications by RIVM employees >
Infectious Diseases >
ESAT-6 and CFP-10 in clinical versus environmental isolates of Mycobacterium kansasii.
this identifier to cite or link
to this item:
|Title: ||ESAT-6 and CFP-10 in clinical versus environmental isolates of Mycobacterium kansasii.|
|Citation: ||J. Infect. Dis. 2005, 191(8):1301-10|
|Issue Date: ||15-Apr-2005 |
|PubMed ID: ||15776377|
|Abstract: ||Mycobacterium kansasii consists of 5 genetically distinct groups, of which 2 are associated with human disease. Determinants of the differences in virulence are unknown. Potential genes of interest are esat-6 and cfp-10, which are associated with virulence of Mycobacterium tuberculosis and Mycobacterium bovis but are lacking in bacille Calmette-Guérin and in most environmental mycobacteria (M. kansasii is an exception). We investigated esat-6 and cfp-10 genes in 22 clinical and 14 environmental isolates of M. kansasii. Both were present in all isolates; each genetic group had its own characteristic Southern-blot pattern corresponding to a highly conserved fingerprint pattern. Nucleotide sequences of the genes differed 12.6% and 10.1%, respectively, from the M. tuberculosis homologues, but the deduced amino acid sequences were <5% different. In vitro, clinical and environmental genotypes of M. kansasii expressed CFP-10 and ESAT-6. Thus, virulence of M. kansasii is not directly related to esat-6 and cfp-10 genes or gene expression.|
|Appears in Collections: || Infectious Diseases|
|Files in This Item:|
|Related articles on PubMed|
Immune responses to defined antigens of Mycobacterium bovis in cattle experimentally infected with Mycobacterium kansasii.
Waters WR, Palmer MV, Thacker TC, Payeur JB, Harris NB, Minion FC, Greenwald R, Esfandiari J, Andersen P, McNair J, Pollock JM, Lyashchenko KP
|See all 197 articles|
All Items in WARP are protected by copyright, with all rights reserved, unless otherwise indicated.