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Webbased Archive of RIVM Publications > Articles and other publications by RIVM employees > Substances > Structure elucidation of sildenafil analogues in herbal products.


Please use this identifier to cite or link to this item: http://hdl.handle.net/10029/11381
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Title: Structure elucidation of sildenafil analogues in herbal products.
Authors: Blok-Tip, L
Zomer, B
Bakker, F
Hartog, K D
Hamzink, M
Hove, J ten
Vredenbregt, M
Kaste, D de
Citation: Food Addit Contam 2004, 21(8):737-48
Issue Date: 1-Aug-2004
URI: http://hdl.handle.net/10029/11381
DOI: 10.1080/02652030412331272467
PubMed ID: 15370823
Abstract: The structure of unknown compounds present in herbal products was elucidated using liquid chromatography-electrospray ionization-mass spectrometry, direct-infusion electrospray ionization-mass spectrometry, and nuclear magnetic resonance. Compounds 1-3 were identified as sildenafil analogues, 1 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine, and an acetyl group instead of the sulfonyl group, named acetildenafil, 2 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine (homosildenafil), and 3 bearing an N-hydroxylethylpiperazine moiety instead of an N-methylpiperazine, named hydroxyhomosildenafil. When analysing products marketed for penile erectile dysfunction or marketed as aphrodisiacs, attention should be given to the possible presence of these components.
Type: Article
Language: en
ISSN: 0265-203X
Appears in Collections:  Substances

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