Structure elucidation of sildenafil analogues in herbal products.

2.50
Hdl Handle:
http://hdl.handle.net/10029/11381
Title:
Structure elucidation of sildenafil analogues in herbal products.
Authors:
Blok-Tip, L; Zomer, B; Bakker, F; Hartog, K D; Hamzink, M; Hove, J ten; Vredenbregt, M; Kaste, D de
Abstract:
The structure of unknown compounds present in herbal products was elucidated using liquid chromatography-electrospray ionization-mass spectrometry, direct-infusion electrospray ionization-mass spectrometry, and nuclear magnetic resonance. Compounds 1-3 were identified as sildenafil analogues, 1 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine, and an acetyl group instead of the sulfonyl group, named acetildenafil, 2 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine (homosildenafil), and 3 bearing an N-hydroxylethylpiperazine moiety instead of an N-methylpiperazine, named hydroxyhomosildenafil. When analysing products marketed for penile erectile dysfunction or marketed as aphrodisiacs, attention should be given to the possible presence of these components.
Citation:
Food Addit Contam 2004, 21(8):737-48
Issue Date:
1-Aug-2004
URI:
http://hdl.handle.net/10029/11381
DOI:
10.1080/02652030412331272467
PubMed ID:
15370823
Type:
Article
Language:
en
ISSN:
0265-203X
Appears in Collections:
Substances

Full metadata record

DC FieldValue Language
dc.contributor.authorBlok-Tip, L-
dc.contributor.authorZomer, B-
dc.contributor.authorBakker, F-
dc.contributor.authorHartog, K D-
dc.contributor.authorHamzink, M-
dc.contributor.authorHove, J ten-
dc.contributor.authorVredenbregt, M-
dc.contributor.authorKaste, D de-
dc.date.accessioned2007-04-25T07:42:36Z-
dc.date.available2007-04-25T07:42:36Z-
dc.date.issued2004-08-01-
dc.identifier.citationFood Addit Contam 2004, 21(8):737-48en
dc.identifier.issn0265-203X-
dc.identifier.pmid15370823-
dc.identifier.doi10.1080/02652030412331272467-
dc.identifier.urihttp://hdl.handle.net/10029/11381-
dc.description.abstractThe structure of unknown compounds present in herbal products was elucidated using liquid chromatography-electrospray ionization-mass spectrometry, direct-infusion electrospray ionization-mass spectrometry, and nuclear magnetic resonance. Compounds 1-3 were identified as sildenafil analogues, 1 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine, and an acetyl group instead of the sulfonyl group, named acetildenafil, 2 bearing an N-ethylpiperazine moiety instead of an N-methylpiperazine (homosildenafil), and 3 bearing an N-hydroxylethylpiperazine moiety instead of an N-methylpiperazine, named hydroxyhomosildenafil. When analysing products marketed for penile erectile dysfunction or marketed as aphrodisiacs, attention should be given to the possible presence of these components.en
dc.format.extent168037 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleStructure elucidation of sildenafil analogues in herbal products.en
dc.typeArticleen
dc.format.digYES-
All Items in WARP are protected by copyright, with all rights reserved, unless otherwise indicated.