Subacute toxicity experiment with rats fed a diet containing ergotaminetartrate. 1 General toxicology

2.50
Hdl Handle:
http://hdl.handle.net/10029/255485
Title:
Subacute toxicity experiment with rats fed a diet containing ergotaminetartrate. 1 General toxicology
Authors:
Speijers GJA; Krajnc-Franken MAM; van Leeuwen FXR; Danse LHJC; Loeber JG; Elvers LH; Hoejenbos-Spithout HHM; Janssen GB
Other Titles:
Subacuut toxiciteits onderzoek met ratten gevoed met een dieet met ergotamine-tartraat. 1 Algemeen gedeelte
Abstract:
In this study reduced food intake, food efficiency and growth were noticed at dose levels of 100 mg EAT/kg diet and higher. Slight changes in the red blood parameters were seen in the 100 and 500 mg EAT/kg diet dose groups. Urea concentration was increased in the females of the highest dose group. The urinalyses showed an increased urine production of male of the 100 and 500 mg/kg diet. Endocrinological analyses revealed decreased T4 (500 mg/kg diet) and TSH (100 and 500 mg EAT/kg diet, only in males). Macroscopical examination revealed gaseous distension of the duodenum, pale thyroids, red tail tips and enlarged iliacal lymph nodes. In the females of 20, 100 and 500 mg EAT/kg diet relative heart, brain and liver weights were higher than the control. The relative ovaries weights were increased at the 100 and 500 mg EAT/kg diet levels. In males (100 and 500 mg EAT/kg diet) relative heart and liver weights were elevated. A slight increase in regenerative and degenerative changes in the kidneys, strong activation of the iliacal lymph nodes was seen in the highest dose group. In the tail of the animal of the 500 mg EAT/kg diet group degenerative changes in the longitudinal skeletal muscle, sometimes accompanied by slight fibrosis was observed.<br>
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
31-Oct-1992
URI:
http://hdl.handle.net/10029/255485
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/618312001.html
Type:
Onderzoeksrapport
Language:
en
Sponsors:
HIGB
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorSpeijers GJA-
dc.contributor.authorKrajnc-Franken MAM-
dc.contributor.authorvan Leeuwen FXR-
dc.contributor.authorDanse LHJC-
dc.contributor.authorLoeber JG-
dc.contributor.authorElvers LH-
dc.contributor.authorHoejenbos-Spithout HHM-
dc.contributor.authorJanssen GB-
dc.date.accessioned2012-12-12T12:02:48Z-
dc.date.available2012-12-12T12:02:48Z-
dc.date.issued1992-10-31-
dc.identifier618312001-
dc.identifier.urihttp://hdl.handle.net/10029/255485-
dc.description.abstractIn this study reduced food intake, food efficiency and growth were noticed at dose levels of 100 mg EAT/kg diet and higher. Slight changes in the red blood parameters were seen in the 100 and 500 mg EAT/kg diet dose groups. Urea concentration was increased in the females of the highest dose group. The urinalyses showed an increased urine production of male of the 100 and 500 mg/kg diet. Endocrinological analyses revealed decreased T4 (500 mg/kg diet) and TSH (100 and 500 mg EAT/kg diet, only in males). Macroscopical examination revealed gaseous distension of the duodenum, pale thyroids, red tail tips and enlarged iliacal lymph nodes. In the females of 20, 100 and 500 mg EAT/kg diet relative heart, brain and liver weights were higher than the control. The relative ovaries weights were increased at the 100 and 500 mg EAT/kg diet levels. In males (100 and 500 mg EAT/kg diet) relative heart and liver weights were elevated. A slight increase in regenerative and degenerative changes in the kidneys, strong activation of the iliacal lymph nodes was seen in the highest dose group. In the tail of the animal of the 500 mg EAT/kg diet group degenerative changes in the longitudinal skeletal muscle, sometimes accompanied by slight fibrosis was observed.<br>en
dc.description.sponsorshipHIGB-
dc.format.extent25 p-
dc.language.isoen-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.relation.ispartofRIVM Rapport 618312001-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618312001.html-
dc.subject07nl
dc.subjectergotamine alkaloidennl
dc.subjectdieetnl
dc.subjecteffectennl
dc.subjectgezondheidnl
dc.subjecttoxiciteitstestennl
dc.subjectatrofienl
dc.subjectdiermodelnl
dc.subjectmuscular atrophynl
dc.subjectspieratrofienl
dc.subjectergotamine alkaloidsen
dc.subjectdieten
dc.subjecthealth effectsen
dc.subjecttoxicity testingen
dc.subjectatrophyen
dc.subjectanimal modelsen
dc.titleSubacute toxicity experiment with rats fed a diet containing ergotaminetartrate. 1 General toxicologyen
dc.title.alternativeSubacuut toxiciteits onderzoek met ratten gevoed met een dieet met ergotamine-tartraat. 1 Algemeen gedeeltenl
dc.typeOnderzoeksrapport-
dc.date.updated2012-12-12T12:02:49Z-
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