Orienterend semi-chronisch onderzoek naar de invloed van gekookte koffie op het cholesterol metabolisme van de Wistar rat

2.50
Hdl Handle:
http://hdl.handle.net/10029/255600
Title:
Orienterend semi-chronisch onderzoek naar de invloed van gekookte koffie op het cholesterol metabolisme van de Wistar rat
Authors:
Janssen GB; Speijers GJA; van Loenen HA; Verschuren WMM; van Soolingen J
Other Titles:
Pilot semi-chronic experiment towards the influence of brewed coffee on the cholesterol metabolism of the Wistar rat
Abstract:
The effects of brewed coffee on the cholesterol metabolism of the Wistar rat were investigated. Male rats were housed for 12 weeks in three groups of 8 animals and were giving drinking water or drinking water containing diluted brewed coffee. Dosis brewed coffee were such that the total intake of brewed coffee was equal to resp. 0, 10 - 15 and 20 - 30 cups of coffee per day for a man weighing 60 kg. Parameters studied comprised growth, food intake, water intake and cholesterol metabolism (total cholesterol, HDL-cholesterol, ratio HDL-cholesterol/total cholesterol, triglycerides, fosfolipids and the percentages lipoprotein). No effects of brewed coffee were seen on growth, food intake, water intake and cholesterol metabolism. Different causes may have had their influence on this insusceptibility. Most likely however is the insusceptibility of the rat for components which influence the cholesterol metabolism. Recommendations for future investigaitons twords the cholesterol increasing effects of brewed coffee are: 1) Investigaitons with a susceptible species such as rabbits and preferably with the AX/JU rabbit. 2) Divide the animals according to a good balanced experimental design that is in such a manner that the mean cholesterol concentrations and the standard deviation of the groups are equal. 3) The brewed coffee may be supplied by two oral routes by way of drinking and by way of consuming food in which lyphilized brewed coffee is mixed.<br>
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
28-Feb-1991
URI:
http://hdl.handle.net/10029/255600
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/618471004.html
Type:
Onderzoeksrapport
Language:
nl
Sponsors:
HIGB; VHI; DGM/SR; RIVM
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorJanssen GB-
dc.contributor.authorSpeijers GJA-
dc.contributor.authorvan Loenen HA-
dc.contributor.authorVerschuren WMM-
dc.contributor.authorvan Soolingen J-
dc.date.accessioned2012-12-12T12:11:15Z-
dc.date.available2012-12-12T12:11:15Z-
dc.date.issued1991-02-28-
dc.identifier618471004-
dc.identifier.urihttp://hdl.handle.net/10029/255600-
dc.description.abstractThe effects of brewed coffee on the cholesterol metabolism of the Wistar rat were investigated. Male rats were housed for 12 weeks in three groups of 8 animals and were giving drinking water or drinking water containing diluted brewed coffee. Dosis brewed coffee were such that the total intake of brewed coffee was equal to resp. 0, 10 - 15 and 20 - 30 cups of coffee per day for a man weighing 60 kg. Parameters studied comprised growth, food intake, water intake and cholesterol metabolism (total cholesterol, HDL-cholesterol, ratio HDL-cholesterol/total cholesterol, triglycerides, fosfolipids and the percentages lipoprotein). No effects of brewed coffee were seen on growth, food intake, water intake and cholesterol metabolism. Different causes may have had their influence on this insusceptibility. Most likely however is the insusceptibility of the rat for components which influence the cholesterol metabolism. Recommendations for future investigaitons twords the cholesterol increasing effects of brewed coffee are: 1) Investigaitons with a susceptible species such as rabbits and preferably with the AX/JU rabbit. 2) Divide the animals according to a good balanced experimental design that is in such a manner that the mean cholesterol concentrations and the standard deviation of the groups are equal. 3) The brewed coffee may be supplied by two oral routes by way of drinking and by way of consuming food in which lyphilized brewed coffee is mixed.<br>en
dc.description.sponsorshipHIGB-
dc.description.sponsorshipVHI-
dc.description.sponsorshipDGM/SR-
dc.description.sponsorshipRIVM-
dc.format.extent15 p-
dc.language.isonl-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.relation.ispartofRIVM Rapport 618471004-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618471004.html-
dc.subject07nl
dc.subject91-2nl
dc.subjectgekookte koffienl
dc.subjectcholesterolnl
dc.subjectlipidenl
dc.subjectboiled coffeenl
dc.subjectlipidnl
dc.titleOrienterend semi-chronisch onderzoek naar de invloed van gekookte koffie op het cholesterol metabolisme van de Wistar ratnl
dc.title.alternativePilot semi-chronic experiment towards the influence of brewed coffee on the cholesterol metabolism of the Wistar raten
dc.typeOnderzoeksrapport-
dc.date.updated2012-12-12T12:11:16Z-
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