Physiologically Based Modelling of Dioxins. I. Validation of a rodent toxicokinetic model

2.50
Hdl Handle:
http://hdl.handle.net/10029/255603
Title:
Physiologically Based Modelling of Dioxins. I. Validation of a rodent toxicokinetic model
Authors:
Zeilmaker MJ; Slob W
Other Titles:
[Fysiologische modellering van dioxinen ; I. Validatie van een toxicokinetisch model voor knaagdieren.]
Abstract:
In this report a rodent Physiologically Based PharmacoKinetic (PBPK) model for 2,3,7,8-tetrachlorodibenzodioxin is described. Validation studies, in which model simulations of TCDD disposition were compared with in vivo TCDD disposition in rodents exposed to TCDD, showed that the model adequately predicted the in vivo toxicokinetics of TCDD across species (mouse, rat), dose-schedule (acute <=> semi-chronic <=> chronic) and route of administration (oral <=> subcutaneous). It was concluded that PBPK models are suited to establish quantitative relationships between the external dose of TCDD (amount of TCDD administered per kg body weight) and the internal dose (concentration of TCDD at the organ level). The relationship between internal dose and the resulting organ toxicity will be elaborated in subsequent reports. The results will be used in a quantitative risk assessment of the human exposure situation, in particular the exposure of suckling infants to dioxins from mother's milk.<br>
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
31-Oct-1993
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/770501007.html
Type:
Onderzoeksrapport
Language:
en
Sponsors:
Interdepartementale Coordinatie Commissie Dioxinen; HIMH; VROM; WVC; LNV
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorZeilmaker MJ-
dc.contributor.authorSlob W-
dc.date.accessioned2013-06-13T21:04:20-
dc.date.issued1993-10-31-
dc.identifier770501007-
dc.description.abstractIn this report a rodent Physiologically Based PharmacoKinetic (PBPK) model for 2,3,7,8-tetrachlorodibenzodioxin is described. Validation studies, in which model simulations of TCDD disposition were compared with in vivo TCDD disposition in rodents exposed to TCDD, showed that the model adequately predicted the in vivo toxicokinetics of TCDD across species (mouse, rat), dose-schedule (acute <=> semi-chronic <=> chronic) and route of administration (oral <=> subcutaneous). It was concluded that PBPK models are suited to establish quantitative relationships between the external dose of TCDD (amount of TCDD administered per kg body weight) and the internal dose (concentration of TCDD at the organ level). The relationship between internal dose and the resulting organ toxicity will be elaborated in subsequent reports. The results will be used in a quantitative risk assessment of the human exposure situation, in particular the exposure of suckling infants to dioxins from mother's milk.<br>en
dc.description.sponsorshipInterdepartementale Coordinatie Commissie Dioxinen-
dc.description.sponsorshipHIMH-
dc.description.sponsorshipVROM-
dc.description.sponsorshipWVC-
dc.description.sponsorshipLNV-
dc.format.extent34 p-
dc.language.isoen-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.relation.ispartofRIVM Rapport 770501007-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/770501007.html-
dc.subject07nl
dc.subjectdioxinenl
dc.subjecttoxicokinetieknl
dc.subjectdiermodelnl
dc.subjectknaagdierennl
dc.subjectvalidatienl
dc.subjectpcdden
dc.subjecttoxicokinetic studiesen
dc.subjectanimal modelsen
dc.subjectrodentiaen
dc.subjectvalidationen
dc.subjectinterspecies extrapolation internal doseen
dc.subjectah-receptor bindingen
dc.subjectenzyme inductionen
dc.titlePhysiologically Based Modelling of Dioxins. I. Validation of a rodent toxicokinetic modelen
dc.title.alternative[Fysiologische modellering van dioxinen ; I. Validatie van een toxicokinetisch model voor knaagdieren.]nl
dc.typeOnderzoeksrapport-
dc.date.updated2013-06-13T19:04:21Z-
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