Impact of UV-B irradiation on resistance to infectious diseases and efficacy of vaccination

2.50
Hdl Handle:
http://hdl.handle.net/10029/255661
Title:
Impact of UV-B irradiation on resistance to infectious diseases and efficacy of vaccination
Authors:
van Loveren H; de Gruijl FR; Bouwes-Bavinck JN; Termorshuizen F; Sleijffers A; Slapper H; Kelfkens G; Garssen J
Other Titles:
Effect van UV-straling op de weerstand tegen infectieziekten
Abstract:
Recent studies on the immunosuppressive effects of UVR and the related resistance to infections in humans are presented. The waveband dependency of trans-to-cis isomerisation of urocanic acid in the stratum corneum and the role of DNA damage in UVR-induced erythema and immunosuppression were investigated to further elucidate the underlying mechanisms. Furthermore, human experimental studies on UVR-induced immunomodulation were performed. It appeared that the doses needed to suppress various immune parameters in humans (e.g. NK-activity, contact hypersensitivity) were higher than those needed in experiments in rodents. Still, extrapolation of experimental animal data to the human situation showed that UVR may impair the resistance to different systemic infections at relevant outdoor doses. In observational human studies we aimed to substantiate the relevance of UVR for infections in humans. It was shown that sunny season was associated with a slightly retarded but clinically non-relevant antibody response to hepatitis B vaccination. Furthermore, sunny season appeared to be associated with a small decline in the number of CD4+ T-helper cells in a cohort of HIV infected persons and a higher recurrence of herpes simplex and herpes zoster in a cohort of renal transplant recipients. However, in a study among young children a higher exposure to solar UVR was associated with a lower occurrence of upper respiratory tract symptoms. As disentangling the effects of UVR from other relevant factors is often impossible in observational studies, concise quantitative risk estimations for the human situation cannot be given at present.<br>
Affiliation:
NOP; LPI; LSO
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM; Utrecht University; The Netherlands; Leiden University; The Netherlands
Issue Date:
26-Oct-2001
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/410200074.html
Type:
Onderzoeksrapport
Language:
en
ISBN:
90 5851 055 7
Sponsors:
SG-NOP
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorvan Loveren H-
dc.contributor.authorde Gruijl FR-
dc.contributor.authorBouwes-Bavinck JN-
dc.contributor.authorTermorshuizen F-
dc.contributor.authorSleijffers A-
dc.contributor.authorSlapper H-
dc.contributor.authorKelfkens G-
dc.contributor.authorGarssen J-
dc.date.accessioned2014-01-17T14:13:34-
dc.date.issued2001-10-26-
dc.identifier410200074-
dc.identifier.isbn90 5851 055 7-
dc.description.abstractRecent studies on the immunosuppressive effects of UVR and the related resistance to infections in humans are presented. The waveband dependency of trans-to-cis isomerisation of urocanic acid in the stratum corneum and the role of DNA damage in UVR-induced erythema and immunosuppression were investigated to further elucidate the underlying mechanisms. Furthermore, human experimental studies on UVR-induced immunomodulation were performed. It appeared that the doses needed to suppress various immune parameters in humans (e.g. NK-activity, contact hypersensitivity) were higher than those needed in experiments in rodents. Still, extrapolation of experimental animal data to the human situation showed that UVR may impair the resistance to different systemic infections at relevant outdoor doses. In observational human studies we aimed to substantiate the relevance of UVR for infections in humans. It was shown that sunny season was associated with a slightly retarded but clinically non-relevant antibody response to hepatitis B vaccination. Furthermore, sunny season appeared to be associated with a small decline in the number of CD4+ T-helper cells in a cohort of HIV infected persons and a higher recurrence of herpes simplex and herpes zoster in a cohort of renal transplant recipients. However, in a study among young children a higher exposure to solar UVR was associated with a lower occurrence of upper respiratory tract symptoms. As disentangling the effects of UVR from other relevant factors is often impossible in observational studies, concise quantitative risk estimations for the human situation cannot be given at present.<br>en
dc.description.sponsorshipSG-NOP-
dc.format.extent50 p-
dc.language.isoen-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.publisherUtrecht University-
dc.publisherThe Netherlands-
dc.publisherLeiden University-
dc.publisherThe Netherlands-
dc.relation.ispartofGlobal Change NOP-NRP report 410200074-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/410200074.html-
dc.subject02nl
dc.subjectinfectious diseasesen
dc.subjectvaccinationen
dc.subjectresistanceen
dc.titleImpact of UV-B irradiation on resistance to infectious diseases and efficacy of vaccinationen
dc.title.alternativeEffect van UV-straling op de weerstand tegen infectieziektennl
dc.typeOnderzoeksrapport-
dc.contributor.departmentNOP-
dc.contributor.departmentLPI-
dc.contributor.departmentLSO-
dc.date.updated2014-01-17T13:15:52Z-
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