2.50
Hdl Handle:
http://hdl.handle.net/10029/256085
Title:
Fish as biomarkers in immunotoxicology
Authors:
Wester PW; Vethaak AD; Muiswinkel WB van; Leewis RJ
Other Titles:
[Vissen als biomarkers voor immunotoxicologie.]
Abstract:
Abstract niet beschikbaar

This report presents a brief survey on the state of the art in the development and application of biomarkers for immunotoxicology in fish. There are several reasons for developing this field: many fish diseases are related to environmental quality, various environmental pollutants have immunotoxic potential and many fish diseases have an immunological component. As in immunotoxicology in general, in fish this aspect has received ample attention in the recent past. Much benefit has been obtained from progress in related fields of science, such as fish immunology and rodent immunotoxicology. To date there is a broad spectrum of potential biomarkers for immunotoxicology in fish, from which macrophage parameters seem to be most widely used. The application of others and more predictive for specific immunity, such as lymphoid cell parameters is still limited, probably due to practical problems such as lack of experience with conduct, validation and interpretation. Specific problems include the paucity of background data in the case of epidemiological field studies and the important role of other (non-chemical) stress factors in the immune response, and hence the lack of specificity of potential biomarkers. It is concluded that a promising arsenal of biomarkers does exist, but further development and validation are still needed.
Affiliation:
PAT; LWD; VW/Dienst Getijdewateren; LUW
Issue Date:
30-Nov-1993
URI:
http://hdl.handle.net/10029/256085
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/733005001.html
Type:
Onderzoeksrapport
Language:
en
Sponsors:
RIVM
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorWester PW-
dc.contributor.authorVethaak AD-
dc.contributor.authorMuiswinkel WB van-
dc.contributor.authorLeewis RJ-
dc.date.accessioned2012-12-12T13:30:21Z-
dc.date.available2012-12-12T13:30:21Z-
dc.date.issued1993-11-30-
dc.identifier733005001-
dc.identifier.urihttp://hdl.handle.net/10029/256085-
dc.description.abstractAbstract niet beschikbaarnl
dc.description.abstractThis report presents a brief survey on the state of the art in the development and application of biomarkers for immunotoxicology in fish. There are several reasons for developing this field: many fish diseases are related to environmental quality, various environmental pollutants have immunotoxic potential and many fish diseases have an immunological component. As in immunotoxicology in general, in fish this aspect has received ample attention in the recent past. Much benefit has been obtained from progress in related fields of science, such as fish immunology and rodent immunotoxicology. To date there is a broad spectrum of potential biomarkers for immunotoxicology in fish, from which macrophage parameters seem to be most widely used. The application of others and more predictive for specific immunity, such as lymphoid cell parameters is still limited, probably due to practical problems such as lack of experience with conduct, validation and interpretation. Specific problems include the paucity of background data in the case of epidemiological field studies and the important role of other (non-chemical) stress factors in the immune response, and hence the lack of specificity of potential biomarkers. It is concluded that a promising arsenal of biomarkers does exist, but further development and validation are still needed.en
dc.description.sponsorshipRIVM-
dc.format.extent27 p-
dc.language.isoen-
dc.relation.ispartofRIVM Rapport 733005001-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/733005001.html-
dc.subject03nl
dc.subjecttoxiciteitstestennl
dc.subjectimmunotoxiciteitnl
dc.subjectimmunotoxicologienl
dc.subjectbiomarkersnl
dc.subjectvissennl
dc.subjectvisziektennl
dc.subjecttoxicity testingen
dc.subjectimmunotoxicityen
dc.subjectbiological markersen
dc.subjectfishesen
dc.subjectfish diseasesen
dc.titleFish as biomarkers in immunotoxicologyen
dc.title.alternative[Vissen als biomarkers voor immunotoxicologie.]nl
dc.typeOnderzoeksrapport-
dc.contributor.departmentPAT-
dc.contributor.departmentLWD-
dc.contributor.departmentVW/Dienst Getijdewateren-
dc.contributor.departmentLUW-
dc.date.updated2012-12-12T13:30:21Z-
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