Toxicological investigation of benzylbutylphthalate in rats

2.50
Hdl Handle:
http://hdl.handle.net/10029/256147
Title:
Toxicological investigation of benzylbutylphthalate in rats
Authors:
van den Ham WA; Jansen EHJM; de Fluiter P; van Leeuwen FXR
Other Titles:
[Toxicologisch onderzoek naar benzylbutylftalaat in ratten.]
Abstract:
In a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg benzylbutylphthalate (BBP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH)) have been determined in liver homogenates. No effect has been observed on the liver weight. The body weight showed a significant decrease as the highest dose level. PCO and CAT showed no effect up to 600 mg BBP/kg diet. LAH was more sensitive with a dose-without-effect (DWE) of 200 mg BBP/kg diet, corresponding with 19.1 mg BBP/kg b.w./day. ECH appeared to be the most sensitive parameter with an effect in all dose levels used. Therefore, no overall no-observed effect level can be defined in this experiment.<br>
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
31-Dec-1992
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/618902010.html
Type:
Onderzoeksrapport
Language:
en
Sponsors:
HIGB
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorvan den Ham WA-
dc.contributor.authorJansen EHJM-
dc.contributor.authorde Fluiter P-
dc.contributor.authorvan Leeuwen FXR-
dc.date.accessioned2014-01-17T13:46:52-
dc.date.issued1992-12-31-
dc.identifier618902010-
dc.description.abstractIn a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg benzylbutylphthalate (BBP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH)) have been determined in liver homogenates. No effect has been observed on the liver weight. The body weight showed a significant decrease as the highest dose level. PCO and CAT showed no effect up to 600 mg BBP/kg diet. LAH was more sensitive with a dose-without-effect (DWE) of 200 mg BBP/kg diet, corresponding with 19.1 mg BBP/kg b.w./day. ECH appeared to be the most sensitive parameter with an effect in all dose levels used. Therefore, no overall no-observed effect level can be defined in this experiment.<br>en
dc.description.sponsorshipHIGB-
dc.format.extent33 p-
dc.language.isoen-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.relation.ispartofRIVM Rapport 618902010-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618902010.html-
dc.subject07nl
dc.subjectftalatennl
dc.subjectbenzylbutylftalaatnl
dc.subjecttoxiciteitstestnl
dc.subjectdierproevennl
dc.subjectenzymennl
dc.subjectphthalatesen
dc.subjectbenzylbutylphthalateen
dc.subjecttoxicity testingen
dc.subjectnelen
dc.subjectanimal modelsen
dc.subjectenzymesen
dc.titleToxicological investigation of benzylbutylphthalate in ratsen
dc.title.alternative[Toxicologisch onderzoek naar benzylbutylftalaat in ratten.]nl
dc.typeOnderzoeksrapport-
dc.date.updated2014-01-17T12:49:23Z-
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