An investigation of the pathophysiological mechanisms of hydrofluoric acid intoxication in rats and pigs. Interim report concerning the results of phase 2.1: The effect of sodium fluoride infusion on the plasma concentrations of lactate and magnesium

2.50
Hdl Handle:
http://hdl.handle.net/10029/256229
Title:
An investigation of the pathophysiological mechanisms of hydrofluoric acid intoxication in rats and pigs. Interim report concerning the results of phase 2.1: The effect of sodium fluoride infusion on the plasma concentrations of lactate and magnesium
Authors:
Boink ABTJ; de Wildt DJ; de Jong Y; de Groot G; Vaessen HAMG; Meulenbelt J; van Dijk A; Vosmeer H
Other Titles:
Onderzoek naar pathofysiologische mechanismen van fluorwaterstof intoxicaties in ratten en varkens. Interim rapport betreffende de resultaten van fase 2.1: De effecten van natriumfluoride op de plasma concentratie van lactaat en magnesium.
Abstract:
From a previous study it was concluded that intravenous infusion of sodium fluoride (NaF) in rats is a suitable model to study the toxicity of hydrofluoric acid. In this supplementary study we investigated the effect of intravenous infusion of a high and low dose of NaF (120 and 25 mg.kg -1.hr -1) on the plasma concentration of lactate, magnesium, potassium and inorganic phosphate. As compared to the control groups an increase of the lactate concentration in plasma was found, mainly in the terminal phase of the NaF infusion period. This indicates that the decrease of base excess which is frequently found in fluoride intoxications, is caused by tissue hypoxia following impaired circulation. The magnesium concentration in plasma decreased steadily during both NaF infusions. Because magnesium ions have an essential role in many enzymatic processes and because changes of the magnesium concentration in plasma exert hemodynamical effects further studies into the consequences of these finding seem justified. In the terminal stage of NaF infusion hyperkalemia was observed. From our experiments it is unclear whether this rise of the potassium concentration is due to fluoride itself, the treatment-induced acidosis, or that cell necrosis due to hypoperfusion is responsible for this increase.<br>
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
31-Aug-1990
URI:
http://hdl.handle.net/10029/256229
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/318802002.html
Type:
Onderzoeksrapport
Language:
en
Sponsors:
RIVM
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorBoink ABTJ-
dc.contributor.authorde Wildt DJ-
dc.contributor.authorde Jong Y-
dc.contributor.authorde Groot G-
dc.contributor.authorVaessen HAMG-
dc.contributor.authorMeulenbelt J-
dc.contributor.authorvan Dijk A-
dc.contributor.authorVosmeer H-
dc.date.accessioned2012-12-12T13:41:34Z-
dc.date.available2012-12-12T13:41:34Z-
dc.date.issued1990-08-31-
dc.identifier318802002-
dc.identifier.urihttp://hdl.handle.net/10029/256229-
dc.description.abstractFrom a previous study it was concluded that intravenous infusion of sodium fluoride (NaF) in rats is a suitable model to study the toxicity of hydrofluoric acid. In this supplementary study we investigated the effect of intravenous infusion of a high and low dose of NaF (120 and 25 mg.kg -1.hr -1) on the plasma concentration of lactate, magnesium, potassium and inorganic phosphate. As compared to the control groups an increase of the lactate concentration in plasma was found, mainly in the terminal phase of the NaF infusion period. This indicates that the decrease of base excess which is frequently found in fluoride intoxications, is caused by tissue hypoxia following impaired circulation. The magnesium concentration in plasma decreased steadily during both NaF infusions. Because magnesium ions have an essential role in many enzymatic processes and because changes of the magnesium concentration in plasma exert hemodynamical effects further studies into the consequences of these finding seem justified. In the terminal stage of NaF infusion hyperkalemia was observed. From our experiments it is unclear whether this rise of the potassium concentration is due to fluoride itself, the treatment-induced acidosis, or that cell necrosis due to hypoperfusion is responsible for this increase.<br>en
dc.description.sponsorshipRIVM-
dc.format.extent39 p-
dc.language.isoen-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.relation.ispartofRIVM Rapport 318802002-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/318802002.html-
dc.subject07nl
dc.subjectfluoridenl
dc.subjectfluorwaterstofnl
dc.subjecttoxiciteitnl
dc.subjectlactaatnl
dc.subjectmagnesiumnl
dc.subjectkalium; anorganisch fosfaatnl
dc.subjectgeioniseerd calciumnl
dc.subjecthartfunctienl
dc.subjecthemodynamiek; zuur-base evenwichtnl
dc.subjectbloedgassen.nl
dc.titleAn investigation of the pathophysiological mechanisms of hydrofluoric acid intoxication in rats and pigs. Interim report concerning the results of phase 2.1: The effect of sodium fluoride infusion on the plasma concentrations of lactate and magnesiumen
dc.title.alternativeOnderzoek naar pathofysiologische mechanismen van fluorwaterstof intoxicaties in ratten en varkens. Interim rapport betreffende de resultaten van fase 2.1: De effecten van natriumfluoride op de plasma concentratie van lactaat en magnesium.nl
dc.typeOnderzoeksrapport-
dc.date.updated2012-12-12T13:41:35Z-
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