Toxicological investigation of di(cyclohexyl)phthalate in rats

2.50
Hdl Handle:
http://hdl.handle.net/10029/256245
Title:
Toxicological investigation of di(cyclohexyl)phthalate in rats
Authors:
van den Ham WA; Jansen EHJM; de Fluiter P; van Leeuwen FXR
Other Titles:
[Toxicologisch onderzoek naar di(cyclohexyl)ftalaat in ratten.]
Abstract:
In a study in which male rats have been exposed to 0, 20, 60, 200, 600 and 2000 mg di(cyclohexyl)phthalate (DCHP)/kg diet for 2 weeks, body weight and liver weight and a number of enzym parameters which are related with peroxisome proliferation palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effects have been observed on the liver and body weights. CAT showed no effect up to 600 mg DCHP/kg diet. PCO and LAH were more sensitive with a dose-without-effect (DWE) of 200 mg DCHP/kg diet. ECH, an enzyme involved in the beta-oxidation, appeared to be the most sensitive parameter with a dose-without-effect of 60 mg DCHP/kg diet. Therefore an overall no-observed-effect-level of 60 mg DCHP/kg diet was defined corresponding to 5.8 mg DCHP/kg b.w./day.<br>
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
31-Dec-1992
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/618902011.html
Type:
Onderzoeksrapport
Language:
en
Sponsors:
HIGB
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorvan den Ham WA-
dc.contributor.authorJansen EHJM-
dc.contributor.authorde Fluiter P-
dc.contributor.authorvan Leeuwen FXR-
dc.date.accessioned2014-01-17T13:39:01-
dc.date.issued1992-12-31-
dc.identifier618902011-
dc.description.abstractIn a study in which male rats have been exposed to 0, 20, 60, 200, 600 and 2000 mg di(cyclohexyl)phthalate (DCHP)/kg diet for 2 weeks, body weight and liver weight and a number of enzym parameters which are related with peroxisome proliferation palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effects have been observed on the liver and body weights. CAT showed no effect up to 600 mg DCHP/kg diet. PCO and LAH were more sensitive with a dose-without-effect (DWE) of 200 mg DCHP/kg diet. ECH, an enzyme involved in the beta-oxidation, appeared to be the most sensitive parameter with a dose-without-effect of 60 mg DCHP/kg diet. Therefore an overall no-observed-effect-level of 60 mg DCHP/kg diet was defined corresponding to 5.8 mg DCHP/kg b.w./day.<br>en
dc.description.sponsorshipHIGB-
dc.format.extent33 p-
dc.language.isoen-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.relation.ispartofRIVM Rapport 618902011-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618902011.html-
dc.subject07nl
dc.subjectftalatennl
dc.subjectdi(cyclohexyl)ftalaatnl
dc.subjecttoxiciteitstestnl
dc.subjectdierproevennl
dc.subjectenzymennl
dc.subjectphthalatesen
dc.subjectdi(cyclohexyl)phthalateen
dc.subjecttoxicity testingen
dc.subjectnelen
dc.subjectanimal modelsen
dc.subjectenzymesen
dc.titleToxicological investigation of di(cyclohexyl)phthalate in ratsen
dc.title.alternative[Toxicologisch onderzoek naar di(cyclohexyl)ftalaat in ratten.]nl
dc.typeOnderzoeksrapport-
dc.date.updated2014-01-17T12:41:18Z-
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