Toxicological investigation of dibutylphthalate in rats

2.50
Hdl Handle:
http://hdl.handle.net/10029/256253
Title:
Toxicological investigation of dibutylphthalate in rats
Authors:
Jansen EHJM; van den Ham WA; de Fluiter P; van Leeuwen FXR
Other Titles:
Toxicologisch onderzoek van dibutylftalaat in ratten
Abstract:
In a study in which male rats have been exposed to 0, 20, 60, 200, 600 and 2000 mg dibutylphthalate (DBP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO, enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effect has been observed on the body and liver weight. For PCO a dose-without-effect was determined of 600 mg BBP/kg diet. The three other enzymes, ECH, CAT and LAH were more sensitive with a dose-without-effect (DWE) of 200 mg BBP/kg diet. Therefore, an overall no-observed-effect-level of 200 mg BBP/kg diet was established in this experiment, corresponding with 19.9 mg BBP/kg b.w./day.<br>
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
30-Jun-1993
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/618902013.html; http://www.rivm.nl/bibliotheek/rapporten/618902013.pdf
Type:
Onderzoeksrapport
Language:
en
Sponsors:
HIGB
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorJansen EHJM-
dc.contributor.authorvan den Ham WA-
dc.contributor.authorde Fluiter P-
dc.contributor.authorvan Leeuwen FXR-
dc.date.accessioned2014-01-17T13:34:10-
dc.date.issued1993-06-30-
dc.identifier618902013-
dc.description.abstractIn a study in which male rats have been exposed to 0, 20, 60, 200, 600 and 2000 mg dibutylphthalate (DBP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO, enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effect has been observed on the body and liver weight. For PCO a dose-without-effect was determined of 600 mg BBP/kg diet. The three other enzymes, ECH, CAT and LAH were more sensitive with a dose-without-effect (DWE) of 200 mg BBP/kg diet. Therefore, an overall no-observed-effect-level of 200 mg BBP/kg diet was established in this experiment, corresponding with 19.9 mg BBP/kg b.w./day.<br>en
dc.description.sponsorshipHIGB-
dc.formatapplication/pdf-
dc.format.extent34 p-
dc.format.extent767 kb-
dc.language.isoen-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.relation.ispartofRIVM Rapport 618902013-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618902013.html-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618902013.pdf-
dc.subject07nl
dc.subjectdibutylftalaatnl
dc.subjecttoxiciteitstoetsnl
dc.subjectdierproevennl
dc.subjectenzymennl
dc.subjectdibutyl phthalateen
dc.subjecttoxicity testingen
dc.subjectnelen
dc.subjectanimal modelsen
dc.subjectenzymesen
dc.subjectdbpen
dc.subjectperoxisome proliferationen
dc.subjectpalmitoyl coenzyme-a oxidaseen
dc.subjectpcoen
dc.subjectenoyl coenzyme-a hydrataseen
dc.subjectechen
dc.subjectcarnitine acetyl transferaseen
dc.subjectcaten
dc.subjectlauric acid hydroxylaseen
dc.subjectlahen
dc.subjectliver homogenatesen
dc.titleToxicological investigation of dibutylphthalate in ratsen
dc.title.alternativeToxicologisch onderzoek van dibutylftalaat in rattennl
dc.typeOnderzoeksrapport-
dc.date.updated2014-01-17T12:36:27Z-
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