Effecten van anaesthetica op de vroege ontwikkeling van de geslachtscellen van de rat

2.50
Hdl Handle:
http://hdl.handle.net/10029/256621
Title:
Effecten van anaesthetica op de vroege ontwikkeling van de geslachtscellen van de rat
Authors:
Garbis-Berkvens JM; Hofstee-Hooftman MWA; Verhoef A; Piersma AH; Peters PWJ; Koeter HBWM
Other Titles:
Effects of anaesthetics on the early development of primordial germ cells in the rat
Abstract:
The effects of prenatal exposure to anaesthetics on the early development of primordial germ cells were studied in the rat. The study consisted of 4 treatment groups: control, low and high dose of halothane + nitrous oxide and galactose as a positive control. Histological and semiquantitative studies of the gonads were performed at day 14 and 21 post coitum. They did not reveal any effect of anaesthetics on the germ cell development of the rat. In the galactose group decreased numbers of germ cells were seen as a result of general growth retardation. The results are described and discussed in view of literature data. This study was part of an experiment designed to study the effects of anaesthetics on reproduction and on pre- and postnatal development in the rat.<br>
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
28-Feb-1991
URI:
http://hdl.handle.net/10029/256621
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/198802001.html
Type:
Onderzoeksrapport
Language:
nl
Sponsors:
SW/DGA; TNO/CIVO; RIVM
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorGarbis-Berkvens JM-
dc.contributor.authorHofstee-Hooftman MWA-
dc.contributor.authorVerhoef A-
dc.contributor.authorPiersma AH-
dc.contributor.authorPeters PWJ-
dc.contributor.authorKoeter HBWM-
dc.date.accessioned2012-12-12T14:15:23Z-
dc.date.available2012-12-12T14:15:23Z-
dc.date.issued1991-02-28-
dc.identifier198802001-
dc.identifier.urihttp://hdl.handle.net/10029/256621-
dc.description.abstractThe effects of prenatal exposure to anaesthetics on the early development of primordial germ cells were studied in the rat. The study consisted of 4 treatment groups: control, low and high dose of halothane + nitrous oxide and galactose as a positive control. Histological and semiquantitative studies of the gonads were performed at day 14 and 21 post coitum. They did not reveal any effect of anaesthetics on the germ cell development of the rat. In the galactose group decreased numbers of germ cells were seen as a result of general growth retardation. The results are described and discussed in view of literature data. This study was part of an experiment designed to study the effects of anaesthetics on reproduction and on pre- and postnatal development in the rat.<br>en
dc.description.sponsorshipSW/DGA-
dc.description.sponsorshipTNO/CIVO-
dc.description.sponsorshipRIVM-
dc.format.extent45 p-
dc.language.isonl-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.relation.ispartofRIVM Rapport 198802001-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/198802001.html-
dc.subject06nl
dc.subject91-1nl
dc.subjectanaestheticanl
dc.subjectprenatale blootstellingnl
dc.subjectgeslachtscellen; anaestheticsnl
dc.subjectprenatal exposurenl
dc.subjectgerm cellsnl
dc.titleEffecten van anaesthetica op de vroege ontwikkeling van de geslachtscellen van de ratnl
dc.title.alternativeEffects of anaesthetics on the early development of primordial germ cells in the raten
dc.typeOnderzoeksrapport-
dc.date.updated2012-12-12T14:15:24Z-
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