N-Nitrosodiethanolamine (NDELA) in cosmetica methode ontwikkeling en monster analyse

2.50
Hdl Handle:
http://hdl.handle.net/10029/256885
Title:
N-Nitrosodiethanolamine (NDELA) in cosmetica methode ontwikkeling en monster analyse
Authors:
Rijst EC van; Schothorst RC
Other Titles:
N-Nitrosodiethanolamine (NDELA) in cosmetics method development and sample analysis
Abstract:
In 1995 is op verzoek van de Inspectie Gezondheids Bescherming de N-nitrosamine problematiek in cosmetische producten in kaart gebracht. Voor het bepalen van NDELA in cosmetica is de GC-TEA methode ontwikkeld en gevalideerd. De terugwinning voor NDELA is gemiddeld 99% (N=4) en de bepaalbaarheidsgrens is 5 mug NDELA / kg cosmetica. De GC-TEA methode is gebruikt om in 48 cosmetische producten, waaronder shampoos, cremes, melk , conditioners en schuimen het NDELA gehalte te bepalen. Alle bepalingen werden in tweevoud uitgevoerd en voor elke 10 cosmetica monsters is een terugwinnings- en blanco-experiment uitgevoerd. De resultaten van deze kwaliteitsexperimenten voldeden aan de kwaliteitskenmerken van de ontwikkelde methode.Van de 48 onderzochte monsters cosmetica bevatten vier monsters meetbare hoeveelheden NDELA.

In response to the 1995 review of the N-nitrosamine problem in cosmetics at the request of the Inspectorate of Health Protection (IGB), a GC-TEA method for determining NDELA in cosmetics has been developed and validated. In a sample diluted with water, adsorbed onto a kieselguhr column and eluted with n-butanol, the average recovery for NDELA is 99% (N=4) and the limit of quantification 5 mug/kg. The GC-TEA method described was used to determine the NDELA content of 48 cosmetics including gels, shampoos, cremes, milks, conditioners and foams. All determinations were done in duplicate and for every 10 cosmetics a recovery experiment and a blank determination were performed. The results of these quality assurance experiments were within the performance characteristics of the method developed. Amounts of NDELA above the limit of quantification of 5 mug/kg were measured in 4 out of the 48 cosmetics.
Affiliation:
ARO
Issue Date:
30-Sep-1997
URI:
http://hdl.handle.net/10029/256885
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/576500001.html
Type:
Onderzoeksrapport
Language:
nl
Sponsors:
IGB
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorRijst EC van-
dc.contributor.authorSchothorst RC-
dc.date.accessioned2012-12-12T14:47:54Z-
dc.date.available2012-12-12T14:47:54Z-
dc.date.issued1997-09-30-
dc.identifier576500001-
dc.identifier.urihttp://hdl.handle.net/10029/256885-
dc.description.abstractIn 1995 is op verzoek van de Inspectie Gezondheids Bescherming de N-nitrosamine problematiek in cosmetische producten in kaart gebracht. Voor het bepalen van NDELA in cosmetica is de GC-TEA methode ontwikkeld en gevalideerd. De terugwinning voor NDELA is gemiddeld 99% (N=4) en de bepaalbaarheidsgrens is 5 mug NDELA / kg cosmetica. De GC-TEA methode is gebruikt om in 48 cosmetische producten, waaronder shampoos, cremes, melk , conditioners en schuimen het NDELA gehalte te bepalen. Alle bepalingen werden in tweevoud uitgevoerd en voor elke 10 cosmetica monsters is een terugwinnings- en blanco-experiment uitgevoerd. De resultaten van deze kwaliteitsexperimenten voldeden aan de kwaliteitskenmerken van de ontwikkelde methode.Van de 48 onderzochte monsters cosmetica bevatten vier monsters meetbare hoeveelheden NDELA.nl
dc.description.abstractIn response to the 1995 review of the N-nitrosamine problem in cosmetics at the request of the Inspectorate of Health Protection (IGB), a GC-TEA method for determining NDELA in cosmetics has been developed and validated. In a sample diluted with water, adsorbed onto a kieselguhr column and eluted with n-butanol, the average recovery for NDELA is 99% (N=4) and the limit of quantification 5 mug/kg. The GC-TEA method described was used to determine the NDELA content of 48 cosmetics including gels, shampoos, cremes, milks, conditioners and foams. All determinations were done in duplicate and for every 10 cosmetics a recovery experiment and a blank determination were performed. The results of these quality assurance experiments were within the performance characteristics of the method developed. Amounts of NDELA above the limit of quantification of 5 mug/kg were measured in 4 out of the 48 cosmetics.en
dc.description.sponsorshipIGB-
dc.format.extent27 p-
dc.language.isonl-
dc.relation.ispartofRIVM rapport 576500001-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/576500001.html-
dc.subject10nl
dc.subjectndelaen
dc.subjectnmpabaoen
dc.subjectcosmeticsen
dc.subjectgc-teaen
dc.subjectmethoden
dc.subjectvalidationen
dc.subjectgelen
dc.subjectcreamen
dc.subjectshampooen
dc.titleN-Nitrosodiethanolamine (NDELA) in cosmetica methode ontwikkeling en monster analysenl
dc.title.alternativeN-Nitrosodiethanolamine (NDELA) in cosmetics method development and sample analysisen
dc.typeOnderzoeksrapport-
dc.contributor.departmentARO-
dc.date.updated2012-12-12T14:47:55Z-
All Items in WARP are protected by copyright, with all rights reserved, unless otherwise indicated.