Comparison of the dose-effect relationship for UV radiation and ionizing radiation

2.50
Hdl Handle:
http://hdl.handle.net/10029/256938
Title:
Comparison of the dose-effect relationship for UV radiation and ionizing radiation
Authors:
Leenhouts HP; Chadwich KH; Sijsma MJ
Other Titles:
Vergelijking van de dosis-effect relatie voor UV-straling en ioniserende straling
Abstract:
Abstract niet beschikbaar

Ionizing radiation and ultraviolet radiation (UV) are both physical agents with mutagenic and carcinogenic properties. However, there are some basic differences in the fundamental mechanism of their interaction with biological material that may have consequences for risk assessment. In this paper the dose-effect relationships for gamma radiation and UV at cellular level will be used to demonstrate the different radiobiological effectiveness of both agents. The results will be discussed in the framework of a biophysical model. This model is based on the assumption that DNA double-stranded lesions are crucial for the cytotoxic action. After exposure to ionizing radiation, the lesions are fixed immediately following irradiation, but after UV exposure the lethal lesions are recognized only in the next DNA systhesis phase. The combination of this concept with the mechanism of lesion induction and the possibility of repair, leads to different dose and time relationships for the radiation effects of both agents. The possi8ble consequences for risk assessment at low dose levels will be discussed.
Issue Date:
30-Jun-1990
URI:
http://hdl.handle.net/10029/256938
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/248474001.html
Type:
Onderzoeksrapport
Language:
en
Sponsors:
EG/DG12
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorLeenhouts HP-
dc.contributor.authorChadwich KH-
dc.contributor.authorSijsma MJ-
dc.date.accessioned2012-12-12T14:51:21Z-
dc.date.available2012-12-12T14:51:21Z-
dc.date.issued1990-06-30-
dc.identifier248474001-
dc.identifier.urihttp://hdl.handle.net/10029/256938-
dc.description.abstractAbstract niet beschikbaarnl
dc.description.abstractIonizing radiation and ultraviolet radiation (UV) are both physical agents with mutagenic and carcinogenic properties. However, there are some basic differences in the fundamental mechanism of their interaction with biological material that may have consequences for risk assessment. In this paper the dose-effect relationships for gamma radiation and UV at cellular level will be used to demonstrate the different radiobiological effectiveness of both agents. The results will be discussed in the framework of a biophysical model. This model is based on the assumption that DNA double-stranded lesions are crucial for the cytotoxic action. After exposure to ionizing radiation, the lesions are fixed immediately following irradiation, but after UV exposure the lethal lesions are recognized only in the next DNA systhesis phase. The combination of this concept with the mechanism of lesion induction and the possibility of repair, leads to different dose and time relationships for the radiation effects of both agents. The possi8ble consequences for risk assessment at low dose levels will be discussed.en
dc.description.sponsorshipEG/DG12-
dc.format.extent14 p-
dc.language.isoen-
dc.relation.ispartofRIVM Rapport 248474001-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/248474001.html-
dc.subject16nl
dc.subjectionizing radiationnl
dc.subjectuv radiationnl
dc.subjectdose-effect relationshipnl
dc.subjectdnanl
dc.titleComparison of the dose-effect relationship for UV radiation and ionizing radiationen
dc.title.alternativeVergelijking van de dosis-effect relatie voor UV-straling en ioniserende stralingnl
dc.typeOnderzoeksrapport-
dc.date.updated2012-12-12T14:51:22Z-
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