Geautomatiseerde monsterzuivering door kolomschakeling bij de bepaling van lorazepam in ratteserum met hoge-prestatie vloeistofchromatografie

2.50
Hdl Handle:
http://hdl.handle.net/10029/257117
Title:
Geautomatiseerde monsterzuivering door kolomschakeling bij de bepaling van lorazepam in ratteserum met hoge-prestatie vloeistofchromatografie
Authors:
Koops R; Groot G de
Other Titles:
Automated sample clean-up by column switching in the determination of lorazepam in rat serum with high-performance liquid chromatography
Abstract:
Abstract niet beschikbaar

In this report a study is described on the application of automated sample clean up by column switching in the quantitative determination of lorazepam in rat serum. Extraction of lorazepam from serum is by using a solid-phase extraction procedure with an "High-Hydrophobic" octadecylsilane sorbent. Determination of lorazepam is with high- performance liquid chromatography. The solid-phase extract is separated over a precolumn from serum components by "on line" column switching. Detection is by UV-detection at 230 nm. The extraction recovery (+- standard deviation) is (91 +- 0.7)%. The precision is 2.4% at 1.12 mug/l. The method is adapted to a concentration range from 0.05 to 4.2 mug/l.
Issue Date:
31-Jan-1990
URI:
http://hdl.handle.net/10029/257117
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/388501003.html
Type:
Onderzoeksrapport
Language:
nl
Sponsors:
HIG CBG
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorKoops R-
dc.contributor.authorGroot G de-
dc.date.accessioned2012-12-12T15:05:16Z-
dc.date.available2012-12-12T15:05:16Z-
dc.date.issued1990-01-31-
dc.identifier388501003-
dc.identifier.urihttp://hdl.handle.net/10029/257117-
dc.description.abstractAbstract niet beschikbaarnl
dc.description.abstractIn this report a study is described on the application of automated sample clean up by column switching in the quantitative determination of lorazepam in rat serum. Extraction of lorazepam from serum is by using a solid-phase extraction procedure with an "High-Hydrophobic" octadecylsilane sorbent. Determination of lorazepam is with high- performance liquid chromatography. The solid-phase extract is separated over a precolumn from serum components by "on line" column switching. Detection is by UV-detection at 230 nm. The extraction recovery (+- standard deviation) is (91 +- 0.7)%. The precision is 2.4% at 1.12 mug/l. The method is adapted to a concentration range from 0.05 to 4.2 mug/l.en
dc.description.sponsorshipHIG CBG-
dc.format.extent39 p-
dc.language.isonl-
dc.relation.ispartofRIVM Rapport 388501003-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/388501003.html-
dc.subject08nl
dc.subjectrobotiseringnl
dc.subjectgeneesmiddelanalysenl
dc.subjectfarmacokinetieknl
dc.titleGeautomatiseerde monsterzuivering door kolomschakeling bij de bepaling van lorazepam in ratteserum met hoge-prestatie vloeistofchromatografienl
dc.title.alternativeAutomated sample clean-up by column switching in the determination of lorazepam in rat serum with high-performance liquid chromatographyen
dc.typeOnderzoeksrapport-
dc.date.updated2012-12-12T15:05:17Z-
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