"Impurity profiling" van testosteron-undecanoaat met behulp van vloeistofchromatografie-fourier transform infraroodspectrometrie

2.50
Hdl Handle:
http://hdl.handle.net/10029/257148
Title:
"Impurity profiling" van testosteron-undecanoaat met behulp van vloeistofchromatografie-fourier transform infraroodspectrometrie
Authors:
Somsen GW; Visser T
Other Titles:
["Impurity profiling" of testosterone undecanoate using liquid chromatography coupled to fourier transform infrared spectrometry.]
Abstract:
Abstract niet beschikbaar

Reversed-phase liquid chromatography (RP-LC) has been coupled to Fourier transform infrared spectrometry (FTIR) by means of a spray jet interface. The usefulness of the interface for impurity profiling of steriods has been demonstrated by the analysis of two samples of testosterone undecanoate. Valuable structural information on impurities >=5% was obtained either by library searching of the produced FTIR spectra, or by interpretation. Identification of two of the impurities, testosterone enanthate and testosterone decanoate, was hampered by the fact that both compounds may occur in a crystalline and in an amorphous state. The spectra of the compounds recorded in the amorphous state appeared to be highly similar.
Issue Date:
31-Dec-1992
URI:
http://hdl.handle.net/10029/257148
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/631401002.html
Type:
Onderzoeksrapport
Language:
nl
Sponsors:
RIVM
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorSomsen GW-
dc.contributor.authorVisser T-
dc.date.accessioned2012-12-12T15:12:42Z-
dc.date.available2012-12-12T15:12:42Z-
dc.date.issued1992-12-31-
dc.identifier631401002-
dc.identifier.urihttp://hdl.handle.net/10029/257148-
dc.description.abstractAbstract niet beschikbaarnl
dc.description.abstractReversed-phase liquid chromatography (RP-LC) has been coupled to Fourier transform infrared spectrometry (FTIR) by means of a spray jet interface. The usefulness of the interface for impurity profiling of steriods has been demonstrated by the analysis of two samples of testosterone undecanoate. Valuable structural information on impurities >=5% was obtained either by library searching of the produced FTIR spectra, or by interpretation. Identification of two of the impurities, testosterone enanthate and testosterone decanoate, was hampered by the fact that both compounds may occur in a crystalline and in an amorphous state. The spectra of the compounds recorded in the amorphous state appeared to be highly similar.en
dc.description.sponsorshipRIVM-
dc.format.extent13 p-
dc.language.isonl-
dc.relation.ispartofRIVM Rapport 631401002-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/631401002.html-
dc.subject18nl
dc.subjecttestosteronnl
dc.subjectanalysenl
dc.subjectvloeistofchromatografienl
dc.subjectinfrarood spectrometrienl
dc.subjecttestosteroneen
dc.subjectanalysisen
dc.subjectliquid chromatographyen
dc.subjectinfrared spectrophotometryen
dc.subjectrp-lcen
dc.subjectftiren
dc.title"Impurity profiling" van testosteron-undecanoaat met behulp van vloeistofchromatografie-fourier transform infraroodspectrometrienl
dc.title.alternative["Impurity profiling" of testosterone undecanoate using liquid chromatography coupled to fourier transform infrared spectrometry.]en
dc.typeOnderzoeksrapport-
dc.date.updated2012-12-12T15:12:43Z-
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