Effecten van synthetische IgE-afgeleide peptiden en anti-IgE conjugaatvaccins in het cardiovasculaire systeem van de rat

2.50
Hdl Handle:
http://hdl.handle.net/10029/257155
Title:
Effecten van synthetische IgE-afgeleide peptiden en anti-IgE conjugaatvaccins in het cardiovasculaire systeem van de rat
Authors:
Wemer J; Vleeming W; Hoogerhout P; Poolman JT
Other Titles:
[Effects of synthetic IgE-mediated peptides and anti-IgE conjugatevaccines in the cardiovascular system of the rat.]
Abstract:
In anaphylactic reactions IgE-mediated effects on the pulmonary and cardiovascular system play a pivotal role. The sequence of amino acids of the chains of the IgE-antibody is known and decapeptides can be synthesized resembling that part of the chains which binds to the mast cells resulting in the release of histamine and leucotrienes. In theory these synthetic decapeptides can be used as the first step for the vaccine development. Another approach would be the construction of peptides with binding capacity but no stimulating activity resulting in the blocking of IgE-binding sites on the target cells. In this feasibility study pilot experiments were performed on the isolated heart of the (actively TNP-ovalbumin sensitized) rat with coronary flow as parameter. Although the pilot experiments indicated an approach leading to either effective peptide antagonists or vaccines it was foreseen that reaching this goal the demand on research capacity would be substantial. In defining priorities the final conclusion was reasched to end these experiments.<br>
Affiliation:
TOX; BVM
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
28-Feb-1994
URI:
http://hdl.handle.net/10029/257155
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/319001003.html
Type:
Onderzoeksrapport
Language:
nl
Sponsors:
RIVM
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorWemer J-
dc.contributor.authorVleeming W-
dc.contributor.authorHoogerhout P-
dc.contributor.authorPoolman JT-
dc.date.accessioned2012-12-12T15:09:00Z-
dc.date.available2012-12-12T15:09:00Z-
dc.date.issued1994-02-28-
dc.identifier319001003-
dc.identifier.urihttp://hdl.handle.net/10029/257155-
dc.description.abstractIn anaphylactic reactions IgE-mediated effects on the pulmonary and cardiovascular system play a pivotal role. The sequence of amino acids of the chains of the IgE-antibody is known and decapeptides can be synthesized resembling that part of the chains which binds to the mast cells resulting in the release of histamine and leucotrienes. In theory these synthetic decapeptides can be used as the first step for the vaccine development. Another approach would be the construction of peptides with binding capacity but no stimulating activity resulting in the blocking of IgE-binding sites on the target cells. In this feasibility study pilot experiments were performed on the isolated heart of the (actively TNP-ovalbumin sensitized) rat with coronary flow as parameter. Although the pilot experiments indicated an approach leading to either effective peptide antagonists or vaccines it was foreseen that reaching this goal the demand on research capacity would be substantial. In defining priorities the final conclusion was reasched to end these experiments.<br>en
dc.description.sponsorshipRIVM-
dc.format.extent27 p-
dc.language.isonl-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.relation.ispartofRIVM Rapport 319001003-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/319001003.html-
dc.subject01nl
dc.subjectanafylaxisnl
dc.subjectigenl
dc.subjectbindingnl
dc.subjectsynthetische vaccinsnl
dc.subjectpeptidennl
dc.subjectdiermodelnl
dc.subjectanaphylaxisen
dc.subjectigeen
dc.subjectbinding sitesen
dc.subjectsynthetic vaccinesen
dc.subjectpeptidesen
dc.subjectanimal modelsen
dc.subjectconjugate vaccinesen
dc.subjectconjugaat vaccinsen
dc.titleEffecten van synthetische IgE-afgeleide peptiden en anti-IgE conjugaatvaccins in het cardiovasculaire systeem van de ratnl
dc.title.alternative[Effects of synthetic IgE-mediated peptides and anti-IgE conjugatevaccines in the cardiovascular system of the rat.]en
dc.typeOnderzoeksrapport-
dc.contributor.departmentTOX-
dc.contributor.departmentBVM-
dc.date.updated2012-12-12T15:09:00Z-
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