Toxicological investigation of diethylphthalate in rats

2.50
Hdl Handle:
http://hdl.handle.net/10029/257304
Title:
Toxicological investigation of diethylphthalate in rats
Authors:
Jansen EHJM; van den Ham WA; de Fluiter P; van Leeuwen FXR
Other Titles:
[Toxicologisch onderzoek van diethylftalaat in ratten.]
Abstract:
In a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg diethylphthalate (DEP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effects have been observed on the liver and body weights. PCO and LAH showed no effects up to 2000 and 600 mg DEP/kg diet, respectively. ECH was more sensitive with a dose-without-effect (DWE) of 200 mg/kg diet. Cat was the most sensitive parameter with an effect in all dose groups. Although CAT turned out the most sensitive parameter, this enzyme was not considered in the establishment of an overall no-observed-effect-level for peroxisome proliferation since it is not specific for peroxisome proliferation. The second most sensitive parameter was the ECH activity. Therefore an overall no-observed-effect-level for peroxisome proliferation of 200 mg DEP/kg diet was established corresponding to 19 mg DEP/kg b.w./day.<br>
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
30-Jun-1993
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/618902012.html
Type:
Onderzoeksrapport
Language:
en
Sponsors:
HIGB
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorJansen EHJM-
dc.contributor.authorvan den Ham WA-
dc.contributor.authorde Fluiter P-
dc.contributor.authorvan Leeuwen FXR-
dc.date.accessioned2014-01-17T13:27:06-
dc.date.issued1993-06-30-
dc.identifier618902012-
dc.description.abstractIn a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg diethylphthalate (DEP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effects have been observed on the liver and body weights. PCO and LAH showed no effects up to 2000 and 600 mg DEP/kg diet, respectively. ECH was more sensitive with a dose-without-effect (DWE) of 200 mg/kg diet. Cat was the most sensitive parameter with an effect in all dose groups. Although CAT turned out the most sensitive parameter, this enzyme was not considered in the establishment of an overall no-observed-effect-level for peroxisome proliferation since it is not specific for peroxisome proliferation. The second most sensitive parameter was the ECH activity. Therefore an overall no-observed-effect-level for peroxisome proliferation of 200 mg DEP/kg diet was established corresponding to 19 mg DEP/kg b.w./day.<br>en
dc.description.sponsorshipHIGB-
dc.format.extent34 p-
dc.language.isoen-
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVM-
dc.relation.ispartofRIVM Rapport 618902012-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/618902012.html-
dc.subject07nl
dc.subjectftalatennl
dc.subjectdiethylftalaatnl
dc.subjecttoxiciteitstestennl
dc.subjectdierproevennl
dc.subjectenzymennl
dc.subjectphthalatesen
dc.subjectdiethyl phthalatesen
dc.subjecttoxicity testingen
dc.subjectnelen
dc.subjectanimal modelsen
dc.subjectenzymesen
dc.subjectdepen
dc.subjectperoxisome proliferationen
dc.subjectpalmitoyl coenzyme-a oxidaseen
dc.subjectpcoen
dc.subjectenoyl coenzyme-a hydrataseen
dc.subjectechen
dc.subjectcarnitine acetyl transferaseen
dc.subjectcaten
dc.subjectlauric acid hydroxylaseen
dc.subjectlahen
dc.subjectliver homogenatesen
dc.titleToxicological investigation of diethylphthalate in ratsen
dc.title.alternative[Toxicologisch onderzoek van diethylftalaat in ratten.]nl
dc.typeOnderzoeksrapport-
dc.date.updated2014-01-17T12:29:37Z-
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