Een fysiologisch farmacokinetisch model voor 2,3,7,8-TCDD in de koe

2.50
Hdl Handle:
http://hdl.handle.net/10029/257401
Title:
Een fysiologisch farmacokinetisch model voor 2,3,7,8-TCDD in de koe
Authors:
Derks HJGM; Berende PLM; Everts H; Olling M; Liem AKD; Jong APJM de
Other Titles:
[A physiologically-based pharmacokinetic model for 2,3,7,8-TCDD in the cow.]
Abstract:
Abstract niet beschikbaar

In this report the development of a physiologically-based pharmacokinetic model for 2,3,7,8-TCDD in cows is presented. The following aspects are successively dealt with: - design of the model structure - collection and justification of the parameter values - calibration using published experimental data - validation using recently generated experimental data. Milk fat production rate, body fat volume and bioavailability have been found to be the most important parameters. Optimal performance of the model is achieved if the transfer of 2,3,7,8-TCDD between blood and body fat is, in contract to other tissues, described by a diffusion limited process which seems to be in agreement with the slowness of blood-fat exchange of extremely lipophilic compounds reported previously. During validation the model predictions were found to acceptably agree with experimentally observed 2,3,7,8-TCDD concentrations in milk- and body fat. Extrapolation of the current model to other dioxin congeners or animal species is, at least in principle, possible.
Issue Date:
30-Nov-1993
URI:
http://hdl.handle.net/10029/257401
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/643810001.html
Type:
Onderzoeksrapport
Language:
nl
Sponsors:
VHI LNV/DLO
Appears in Collections:
RIVM official reports

Full metadata record

DC FieldValue Language
dc.contributor.authorDerks HJGM-
dc.contributor.authorBerende PLM-
dc.contributor.authorEverts H-
dc.contributor.authorOlling M-
dc.contributor.authorLiem AKD-
dc.contributor.authorJong APJM de-
dc.date.accessioned2012-12-12T15:34:26Z-
dc.date.available2012-12-12T15:34:26Z-
dc.date.issued1993-11-30-
dc.identifier643810001-
dc.identifier.urihttp://hdl.handle.net/10029/257401-
dc.description.abstractAbstract niet beschikbaarnl
dc.description.abstractIn this report the development of a physiologically-based pharmacokinetic model for 2,3,7,8-TCDD in cows is presented. The following aspects are successively dealt with: - design of the model structure - collection and justification of the parameter values - calibration using published experimental data - validation using recently generated experimental data. Milk fat production rate, body fat volume and bioavailability have been found to be the most important parameters. Optimal performance of the model is achieved if the transfer of 2,3,7,8-TCDD between blood and body fat is, in contract to other tissues, described by a diffusion limited process which seems to be in agreement with the slowness of blood-fat exchange of extremely lipophilic compounds reported previously. During validation the model predictions were found to acceptably agree with experimentally observed 2,3,7,8-TCDD concentrations in milk- and body fat. Extrapolation of the current model to other dioxin congeners or animal species is, at least in principle, possible.en
dc.description.sponsorshipVHI LNV/DLO-
dc.format.extent36 p-
dc.language.isonl-
dc.relation.ispartofRIVM Rapport 643810001-
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/643810001.html-
dc.subject07nl
dc.subjectdioxinenl
dc.subjectfarmacokinetieknl
dc.subjectdiermodelnl
dc.subjectkoenl
dc.subjectpcdden
dc.subjectpharmacokineticsen
dc.subjectanimal modelsen
dc.subjectcattleen
dc.subjecttcdden
dc.titleEen fysiologisch farmacokinetisch model voor 2,3,7,8-TCDD in de koenl
dc.title.alternative[A physiologically-based pharmacokinetic model for 2,3,7,8-TCDD in the cow.]en
dc.typeOnderzoeksrapport-
dc.date.updated2012-12-12T15:34:27Z-
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