Polymorphisms in the genes involved in the arachidonic acid-pathway, fish consumption and the risk of colorectal cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10029/4915
Title:
Polymorphisms in the genes involved in the arachidonic acid-pathway, fish consumption and the risk of colorectal cancer.
Authors:
Siezen, Christine L E; Bueno-de-Mesquita, H Bas; Peeters, Petra H M; Kram, Nicolien R; Doeselaar, Marina van; Kranen, Henk J van
Abstract:
The objective of this study on colorectal cancer was to investigate the associations between SNPs in the genes involved in the arachidonic acid (AA)-pathway, their haplotypes and colorectal cancer. Moreover, interactions between SNPs and fish consumption were considered. In this study, a total of 508 cases and 772 controls were included, originating from 2 prospective cohorts, the Monitoring Project on Cardiovascular Disease Risk Factors (PPHV) and Diagnostisch Onderzoek Mammacarcinoom (DOM). Genotypes of 23 SNPs in 7 candidate genes were determined and the modifying effect of fish consumption was considered. A protective effect of the minor allele of SNP V102V in PTGS2 was observed (odds ratio (OR), 0.37; 95% confidence intervals (CI), 0.16-0.87). The haplotype representing this allele showed a weaker inverse association, indicating that 2 alleles are necessary to obtain this protective effect. Fish consumption data was available for 209 cases and 418 controls. Increased fish consumption was inversely associated with cancer, although not significant (OR, 0.83; 95% CI, 0.57-1.20). Despite the substantial reductions in cancer risk for some genotypes in combination with high fish intake, no significant interactions between any SNP studied and fish consumption were observed. We have previously described an association between colorectal adenomas and SNP V102V in PTGS2 and have now confirmed this association for colorectal adenocarcinomas. Fish consumption of once a week or more might protect against colorectal cancer, but no significant interactions with SNPs in the genes involved in the AA-pathway could be detected within the study.
Citation:
Int. J. Cancer 2006, 119(2):297-303
Issue Date:
15-Jul-2006
URI:
http://hdl.handle.net/10029/4915
DOI:
10.1002/ijc.21858
PubMed ID:
16482563
Type:
Article
Language:
en
ISSN:
0020-7136
Appears in Collections:
Nutrition and Drinking Water

Full metadata record

DC FieldValue Language
dc.contributor.authorSiezen, Christine L E-
dc.contributor.authorBueno-de-Mesquita, H Bas-
dc.contributor.authorPeeters, Petra H M-
dc.contributor.authorKram, Nicolien R-
dc.contributor.authorDoeselaar, Marina van-
dc.contributor.authorKranen, Henk J van-
dc.date.accessioned2006-10-06T08:55:16Z-
dc.date.available2006-10-06T08:55:16Z-
dc.date.issued2006-07-15-
dc.identifier.citationInt. J. Cancer 2006, 119(2):297-303en
dc.identifier.issn0020-7136-
dc.identifier.pmid16482563-
dc.identifier.doi10.1002/ijc.21858-
dc.identifier.urihttp://hdl.handle.net/10029/4915-
dc.description.abstractThe objective of this study on colorectal cancer was to investigate the associations between SNPs in the genes involved in the arachidonic acid (AA)-pathway, their haplotypes and colorectal cancer. Moreover, interactions between SNPs and fish consumption were considered. In this study, a total of 508 cases and 772 controls were included, originating from 2 prospective cohorts, the Monitoring Project on Cardiovascular Disease Risk Factors (PPHV) and Diagnostisch Onderzoek Mammacarcinoom (DOM). Genotypes of 23 SNPs in 7 candidate genes were determined and the modifying effect of fish consumption was considered. A protective effect of the minor allele of SNP V102V in PTGS2 was observed (odds ratio (OR), 0.37; 95% confidence intervals (CI), 0.16-0.87). The haplotype representing this allele showed a weaker inverse association, indicating that 2 alleles are necessary to obtain this protective effect. Fish consumption data was available for 209 cases and 418 controls. Increased fish consumption was inversely associated with cancer, although not significant (OR, 0.83; 95% CI, 0.57-1.20). Despite the substantial reductions in cancer risk for some genotypes in combination with high fish intake, no significant interactions between any SNP studied and fish consumption were observed. We have previously described an association between colorectal adenomas and SNP V102V in PTGS2 and have now confirmed this association for colorectal adenocarcinomas. Fish consumption of once a week or more might protect against colorectal cancer, but no significant interactions with SNPs in the genes involved in the AA-pathway could be detected within the study.en
dc.format.extent394826 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titlePolymorphisms in the genes involved in the arachidonic acid-pathway, fish consumption and the risk of colorectal cancer.en
dc.typeArticleen
dc.format.digYES-

Related articles on PubMed

All Items in WARP are protected by copyright, with all rights reserved, unless otherwise indicated.