Approaches to the risk assessment of genotoxic carcinogens in food: a critical appraisal.

2.50
Hdl Handle:
http://hdl.handle.net/10029/5534
Title:
Approaches to the risk assessment of genotoxic carcinogens in food: a critical appraisal.
Authors:
O'Brien, J; Renwick, A G; Constable, A; Dybing, Erik; Müller, D J G; Schlatter, J; Slob, Wout; Tueting, W; Benthem, Jan van; Williams, G M; Wolfreys, A
Abstract:
The present paper examines the particular difficulties presented by low levels of food-borne DNA-reactive genotoxic carcinogens, some of which may be difficult to eliminate completely from the diet, and proposes a structured approach for the evaluation of such compounds. While the ALARA approach is widely applicable to all substances in food that are both carcinogenic and genotoxic, it does not take carcinogenic potency into account and, therefore, does not permit prioritisation based on potential risk or concern. In the absence of carcinogenicity dose-response data, an assessment based on comparison with an appropriate threshold of toxicological concern may be possible. When carcinogenicity data from animal bioassays are available, a useful analysis is achieved by the calculation of margins of exposure (MOEs), which can be used to compare animal potency data with human exposure scenarios. Two reference points on the dose-response relationship that can be used for MOE calculation were examined; the T25 value, which is derived from linear extrapolation, and the BMDL10, which is derived from mathematical modelling of the dose-response data. The above approaches were applied to selected food-borne genotoxic carcinogens. The proposed approach is applicable to all substances in food that are DNA-reactive genotoxic carcinogens and enables the formulation of appropriate semi-quantitative advice to risk managers.
Citation:
Food Chem. Toxicol. 2006, 44(10):1613-35
Issue Date:
1-Oct-2006
URI:
http://hdl.handle.net/10029/5534
DOI:
10.1016/j.fct.2006.07.004
PubMed ID:
16887251
Type:
Article
Language:
en
ISSN:
0278-6915
Appears in Collections:
Nutrition and Drinking Water

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Brien, J-
dc.contributor.authorRenwick, A G-
dc.contributor.authorConstable, A-
dc.contributor.authorDybing, Erik-
dc.contributor.authorMüller, D J G-
dc.contributor.authorSchlatter, J-
dc.contributor.authorSlob, Wout-
dc.contributor.authorTueting, W-
dc.contributor.authorBenthem, Jan van-
dc.contributor.authorWilliams, G M-
dc.contributor.authorWolfreys, A-
dc.date.accessioned2006-10-24T08:18:08Z-
dc.date.available2006-10-24T08:18:08Z-
dc.date.issued2006-10-01-
dc.identifier.citationFood Chem. Toxicol. 2006, 44(10):1613-35en
dc.identifier.issn0278-6915-
dc.identifier.pmid16887251-
dc.identifier.doi10.1016/j.fct.2006.07.004-
dc.identifier.urihttp://hdl.handle.net/10029/5534-
dc.description.abstractThe present paper examines the particular difficulties presented by low levels of food-borne DNA-reactive genotoxic carcinogens, some of which may be difficult to eliminate completely from the diet, and proposes a structured approach for the evaluation of such compounds. While the ALARA approach is widely applicable to all substances in food that are both carcinogenic and genotoxic, it does not take carcinogenic potency into account and, therefore, does not permit prioritisation based on potential risk or concern. In the absence of carcinogenicity dose-response data, an assessment based on comparison with an appropriate threshold of toxicological concern may be possible. When carcinogenicity data from animal bioassays are available, a useful analysis is achieved by the calculation of margins of exposure (MOEs), which can be used to compare animal potency data with human exposure scenarios. Two reference points on the dose-response relationship that can be used for MOE calculation were examined; the T25 value, which is derived from linear extrapolation, and the BMDL10, which is derived from mathematical modelling of the dose-response data. The above approaches were applied to selected food-borne genotoxic carcinogens. The proposed approach is applicable to all substances in food that are DNA-reactive genotoxic carcinogens and enables the formulation of appropriate semi-quantitative advice to risk managers.en
dc.format.extent480608 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleApproaches to the risk assessment of genotoxic carcinogens in food: a critical appraisal.en
dc.typeArticleen
dc.format.digYES-

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