Dioxin and dioxin-like PCB exposure of non-breastfed Dutch infants.

2.50
Hdl Handle:
http://hdl.handle.net/10029/5542
Title:
Dioxin and dioxin-like PCB exposure of non-breastfed Dutch infants.
Authors:
Weijs, P J M; Bakker, Martine I; Korver, K R; Goor Ghanaviztchi, K van; Wijnen, Joop H van
Abstract:
The exposure of humans to PCDD/Fs (polychlorinated dibenzo-p-dioxins and dibenzofurans) and dioxin-like PCBs (dl-PCBs, i.e. polychlorinated non-ortho and mono-ortho biphenyls) occurs predominantly via the intake of food. Young children have a relatively high intake of these substances, due to their high food consumption per kilogram body weight. As the exposure of non-breastfed infants to these compounds has not been assessed before in The Netherlands, we studied the dietary intake of 17 PCDD/Fs and 11 dioxin-like PCBs in 188 Dutch non-breastfed infants between 4 and 13 months. The food intake of the infants was assessed by a 2-d food record. From these data PCDD/F and dioxin-like PCB intake was calculated using PCDD/F and dioxin-like PCB concentrations of food products sampled in 1998/1999 in The Netherlands. The long-term PCDD/F and dioxin-like PCB exposure of the infants was calculated using the statistical exposure model (STEM). For infants of 5 months the chronic exposure to PCDD/F and dioxin-like PCB was 1.1pg WHO-TEQ (toxic equivalents) per kilogram body weight (bw) per day (95th percentile: 1.7pg WHO-TEQ/kg bwxd), which mainly originated from infant formula and vegetables and increased to 2.3pg WHO-TEQ/kg bwxd (95th percentile 3.7pg WHO-TEQ/kg bwxd) for infants just over 1 year old eating the same food as their parents. The percentage of formula-fed infants with an exposure exceeding the TDI of 2pg WHO-TEQ/kg bwxd was 5% at 5 months, 49% at 9 months and 64% at 12 months.
Citation:
Chemosphere 2006, 64(9):1521-5
Issue Date:
1-Aug-2006
URI:
http://hdl.handle.net/10029/5542
DOI:
10.1016/j.chemosphere.2005.12.022
PubMed ID:
16442144
Type:
Article
Language:
en
ISSN:
0045-6535
Appears in Collections:
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Full metadata record

DC FieldValue Language
dc.contributor.authorWeijs, P J M-
dc.contributor.authorBakker, Martine I-
dc.contributor.authorKorver, K R-
dc.contributor.authorGoor Ghanaviztchi, K van-
dc.contributor.authorWijnen, Joop H van-
dc.date.accessioned2006-10-24T09:23:19Z-
dc.date.available2006-10-24T09:23:19Z-
dc.date.issued2006-08-01-
dc.identifier.citationChemosphere 2006, 64(9):1521-5en
dc.identifier.issn0045-6535-
dc.identifier.pmid16442144-
dc.identifier.doi10.1016/j.chemosphere.2005.12.022-
dc.identifier.urihttp://hdl.handle.net/10029/5542-
dc.description.abstractThe exposure of humans to PCDD/Fs (polychlorinated dibenzo-p-dioxins and dibenzofurans) and dioxin-like PCBs (dl-PCBs, i.e. polychlorinated non-ortho and mono-ortho biphenyls) occurs predominantly via the intake of food. Young children have a relatively high intake of these substances, due to their high food consumption per kilogram body weight. As the exposure of non-breastfed infants to these compounds has not been assessed before in The Netherlands, we studied the dietary intake of 17 PCDD/Fs and 11 dioxin-like PCBs in 188 Dutch non-breastfed infants between 4 and 13 months. The food intake of the infants was assessed by a 2-d food record. From these data PCDD/F and dioxin-like PCB intake was calculated using PCDD/F and dioxin-like PCB concentrations of food products sampled in 1998/1999 in The Netherlands. The long-term PCDD/F and dioxin-like PCB exposure of the infants was calculated using the statistical exposure model (STEM). For infants of 5 months the chronic exposure to PCDD/F and dioxin-like PCB was 1.1pg WHO-TEQ (toxic equivalents) per kilogram body weight (bw) per day (95th percentile: 1.7pg WHO-TEQ/kg bwxd), which mainly originated from infant formula and vegetables and increased to 2.3pg WHO-TEQ/kg bwxd (95th percentile 3.7pg WHO-TEQ/kg bwxd) for infants just over 1 year old eating the same food as their parents. The percentage of formula-fed infants with an exposure exceeding the TDI of 2pg WHO-TEQ/kg bwxd was 5% at 5 months, 49% at 9 months and 64% at 12 months.en
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dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleDioxin and dioxin-like PCB exposure of non-breastfed Dutch infants.en
dc.typeArticleen
dc.format.digYES-

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