The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys.

2.50
Hdl Handle:
http://hdl.handle.net/10029/5601
Title:
The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys.
Authors:
Melker, Hester E de; Versteegh, Florens G A; Schellekens, Joop F P; Teunis, Peter F M; Kretzschmar, Mirjam
Abstract:
OBJECTIVES: Bordetella pertussis circulates even in highly vaccinated populations. There is a considerable amount of infection in adults. For designing more effective vaccination schedules it is important to quantify the age-dependent relation between the number of notified cases and the number of infections. METHODS: We used a statistical relationship between the time since infection and the IgG antibody titers against pertussis toxin, derived from a longitudinal data set, to estimate time since infection for all individuals in a cross-sectional population-based study (1995-1996) based on their titers. Age-specific incidence of infection with B. pertussis was calculated and compared with the age-distribution of notified cases of pertussis in 1994-1996. RESULTS: Estimated incidence of infection was 6.6% per year for 3-79-year olds, annual incidence of notified cases 0.01%. Estimated age-specific incidence of infection was lowest for 3-4-year olds (3.3%) and increased gradually up to the age of 20-24 years (10.8%). The number of notified cases was highest for 3-9-year olds. CONCLUSIONS: In the Dutch population B. pertussis infections occur more frequently and in elder age-categories then suggested by notifications. Mathematical modeling could explore what booster vaccination strategies are most effective in reducing severe disease among not (completely) vaccinated infants.
Citation:
J. Infect. 2006, 53(2):106-13
Issue Date:
1-Aug-2006
URI:
http://hdl.handle.net/10029/5601
DOI:
10.1016/j.jinf.2005.10.020
PubMed ID:
16352342
Type:
Article
Language:
en
ISSN:
0163-4453
Appears in Collections:
Infectious Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorMelker, Hester E de-
dc.contributor.authorVersteegh, Florens G A-
dc.contributor.authorSchellekens, Joop F P-
dc.contributor.authorTeunis, Peter F M-
dc.contributor.authorKretzschmar, Mirjam-
dc.date.accessioned2006-10-26T10:32:39Z-
dc.date.available2006-10-26T10:32:39Z-
dc.date.issued2006-08-01-
dc.identifier.citationJ. Infect. 2006, 53(2):106-13en
dc.identifier.issn0163-4453-
dc.identifier.pmid16352342-
dc.identifier.doi10.1016/j.jinf.2005.10.020-
dc.identifier.urihttp://hdl.handle.net/10029/5601-
dc.description.abstractOBJECTIVES: Bordetella pertussis circulates even in highly vaccinated populations. There is a considerable amount of infection in adults. For designing more effective vaccination schedules it is important to quantify the age-dependent relation between the number of notified cases and the number of infections. METHODS: We used a statistical relationship between the time since infection and the IgG antibody titers against pertussis toxin, derived from a longitudinal data set, to estimate time since infection for all individuals in a cross-sectional population-based study (1995-1996) based on their titers. Age-specific incidence of infection with B. pertussis was calculated and compared with the age-distribution of notified cases of pertussis in 1994-1996. RESULTS: Estimated incidence of infection was 6.6% per year for 3-79-year olds, annual incidence of notified cases 0.01%. Estimated age-specific incidence of infection was lowest for 3-4-year olds (3.3%) and increased gradually up to the age of 20-24 years (10.8%). The number of notified cases was highest for 3-9-year olds. CONCLUSIONS: In the Dutch population B. pertussis infections occur more frequently and in elder age-categories then suggested by notifications. Mathematical modeling could explore what booster vaccination strategies are most effective in reducing severe disease among not (completely) vaccinated infants.en
dc.format.extent201300 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleThe incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys.en
dc.typeArticleen
dc.format.digYES-

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