Combining risk estimates from observational studies with different exposure cutpoints: a meta-analysis on body mass index and diabetes type 2.

2.50
Hdl Handle:
http://hdl.handle.net/10029/5607
Title:
Combining risk estimates from observational studies with different exposure cutpoints: a meta-analysis on body mass index and diabetes type 2.
Authors:
Hartemink, Nienke; Boshuizen, Hendriek C; Nagelkerke, Nico J D; Jacobs, Monique A M; Houwelingen, Hans C van
Abstract:
Studies on a dose-response relation often report separate relative risks for several risk classes compared with a referent class. When performing a meta-analysis of such studies, one has to convert these relative risks into an overall relative risk for a continuous effect. Apart from taking the dependence between separate relative risks into account, this implies assigning an exposure level to each risk factor class and allowing for the nonlinearity of the dose-response relation. The authors describe a relatively simple method solving these problems. As an illustration, they applied this method in a meta-analysis of the association between body mass index and diabetes type 2, restricted to results of follow-up studies (n=31). Results were compared with a more ad hoc method of assigning exposure levels and with a method in which the nonlinearity of the dose-response method was not taken into account. Differences with the ad hoc method were larger in studies with fewer categories. Not incorporating the nonlinearity of the dose response leads to an overestimation of the pooled relative risk, but this bias is relatively small.
Citation:
Am. J. Epidemiol. 2006, 163(11):1042-52
Issue Date:
1-Jun-2006
URI:
http://hdl.handle.net/10029/5607
DOI:
10.1093/aje/kwj141
PubMed ID:
16611666
Type:
Article
Language:
en
ISSN:
0002-9262
Appears in Collections:
Public Health and Health Care

Full metadata record

DC FieldValue Language
dc.contributor.authorHartemink, Nienke-
dc.contributor.authorBoshuizen, Hendriek C-
dc.contributor.authorNagelkerke, Nico J D-
dc.contributor.authorJacobs, Monique A M-
dc.contributor.authorHouwelingen, Hans C van-
dc.date.accessioned2006-10-26T12:08:42Z-
dc.date.available2006-10-26T12:08:42Z-
dc.date.issued2006-06-01-
dc.identifier.citationAm. J. Epidemiol. 2006, 163(11):1042-52en
dc.identifier.issn0002-9262-
dc.identifier.pmid16611666-
dc.identifier.doi10.1093/aje/kwj141-
dc.identifier.urihttp://hdl.handle.net/10029/5607-
dc.description.abstractStudies on a dose-response relation often report separate relative risks for several risk classes compared with a referent class. When performing a meta-analysis of such studies, one has to convert these relative risks into an overall relative risk for a continuous effect. Apart from taking the dependence between separate relative risks into account, this implies assigning an exposure level to each risk factor class and allowing for the nonlinearity of the dose-response relation. The authors describe a relatively simple method solving these problems. As an illustration, they applied this method in a meta-analysis of the association between body mass index and diabetes type 2, restricted to results of follow-up studies (n=31). Results were compared with a more ad hoc method of assigning exposure levels and with a method in which the nonlinearity of the dose-response method was not taken into account. Differences with the ad hoc method were larger in studies with fewer categories. Not incorporating the nonlinearity of the dose response leads to an overestimation of the pooled relative risk, but this bias is relatively small.en
dc.format.extent299768 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleCombining risk estimates from observational studies with different exposure cutpoints: a meta-analysis on body mass index and diabetes type 2.en
dc.typeArticleen
dc.format.digYES-

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