Hepatitis E virus infection in North Italy: high seroprevalence in swine herds and increased risk for swine workers.

2.50
Hdl Handle:
http://hdl.handle.net/10029/620957
Title:
Hepatitis E virus infection in North Italy: high seroprevalence in swine herds and increased risk for swine workers.
Authors:
Mughini-Gras, L; Angeloni, G; Salata, C; Vonesch, N; D'Amico, W; Campagna, G; Natale, A; Zuliani, F; Ceglie, L; Monne, I; Vascellari, M; Capello, K; DI Martino, G; Inglese, N; Palù, G; Tomao, P; Bonfanti, L
Abstract:
We determined the hepatitis E virus (HEV) seroprevalence and detection rate in commercial swine herds in Italy's utmost pig-rich area, and assessed HEV seropositivity risk in humans as a function of occupational exposure to pigs, diet, foreign travel, medical history and hunting activities. During 2011-2014, 2700 sera from 300 swine herds were tested for anti-HEV IgG. HEV RNA was searched in 959 faecal pools from HEV-seropositive herds and in liver/bile/muscle samples from 179 pigs from HEV-positive herds. A cohort study of HEV seropositivity in swine workers (n = 149) was also performed using two comparison groups of people unexposed to swine: omnivores (n = 121) and vegetarians/vegans (n = 115). Herd-level seroprevalence was 75·6% and was highest in farrow-to-feeder herds (81·6%). Twenty-six out of 105 (24·8%) herds had HEV-positive faecal samples (25 HEV-3, one HEV-4). Only one bile sample tested positive. HEV seropositivity was 12·3% in swine workers, 0·9% in omnivores and 3·0% in vegetarians/vegans. Factors significantly associated with HEV seropositivity were occupational exposure to pigs, travel to Africa and increased swine workers' age. We concluded that HEV is widespread in Italian swine herds and HEV-4 circulation is alarming given its pathogenicity, with those occupationally exposed to pigs being at increased risk of HEV seropositivity.
Citation:
Hepatitis E virus infection in North Italy: high seroprevalence in swine herds and increased risk for swine workers. 2017, 145 (16):3375-3384 Epidemiol. Infect.
Journal:
Epidemiology and infection 2017, 145 (16):3375-3384
Issue Date:
Dec-2017
URI:
http://hdl.handle.net/10029/620957
DOI:
10.1017/S0950268817002485
PubMed ID:
29145911
Type:
Article
Language:
en
ISSN:
1469-4409
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorMughini-Gras, Len
dc.contributor.authorAngeloni, Gen
dc.contributor.authorSalata, Cen
dc.contributor.authorVonesch, Nen
dc.contributor.authorD'Amico, Wen
dc.contributor.authorCampagna, Gen
dc.contributor.authorNatale, Aen
dc.contributor.authorZuliani, Fen
dc.contributor.authorCeglie, Len
dc.contributor.authorMonne, Ien
dc.contributor.authorVascellari, Men
dc.contributor.authorCapello, Ken
dc.contributor.authorDI Martino, Gen
dc.contributor.authorInglese, Nen
dc.contributor.authorPalù, Gen
dc.contributor.authorTomao, Pen
dc.contributor.authorBonfanti, Len
dc.date.accessioned2017-12-19T14:22:09Z-
dc.date.available2017-12-19T14:22:09Z-
dc.date.issued2017-12-
dc.identifier.citationHepatitis E virus infection in North Italy: high seroprevalence in swine herds and increased risk for swine workers. 2017, 145 (16):3375-3384 Epidemiol. Infect.en
dc.identifier.issn1469-4409-
dc.identifier.pmid29145911-
dc.identifier.doi10.1017/S0950268817002485-
dc.identifier.urihttp://hdl.handle.net/10029/620957-
dc.description.abstractWe determined the hepatitis E virus (HEV) seroprevalence and detection rate in commercial swine herds in Italy's utmost pig-rich area, and assessed HEV seropositivity risk in humans as a function of occupational exposure to pigs, diet, foreign travel, medical history and hunting activities. During 2011-2014, 2700 sera from 300 swine herds were tested for anti-HEV IgG. HEV RNA was searched in 959 faecal pools from HEV-seropositive herds and in liver/bile/muscle samples from 179 pigs from HEV-positive herds. A cohort study of HEV seropositivity in swine workers (n = 149) was also performed using two comparison groups of people unexposed to swine: omnivores (n = 121) and vegetarians/vegans (n = 115). Herd-level seroprevalence was 75·6% and was highest in farrow-to-feeder herds (81·6%). Twenty-six out of 105 (24·8%) herds had HEV-positive faecal samples (25 HEV-3, one HEV-4). Only one bile sample tested positive. HEV seropositivity was 12·3% in swine workers, 0·9% in omnivores and 3·0% in vegetarians/vegans. Factors significantly associated with HEV seropositivity were occupational exposure to pigs, travel to Africa and increased swine workers' age. We concluded that HEV is widespread in Italian swine herds and HEV-4 circulation is alarming given its pathogenicity, with those occupationally exposed to pigs being at increased risk of HEV seropositivity.en
dc.language.isoenen
dc.rightsArchived with thanks to Epidemiology and infectionen
dc.titleHepatitis E virus infection in North Italy: high seroprevalence in swine herds and increased risk for swine workers.en
dc.typeArticleen
dc.identifier.journalEpidemiology and infection 2017, 145 (16):3375-3384en

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