The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621043
Title:
The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation.
Authors:
Dekkers, Susan; Miller, Mark R; Schins, Roel P F; Römer, Isabella; Russ, Mike; Vandebriel, Rob J; Lynch, Iseult; Belinga-Desaunay, Marie-France; Valsami-Jones, Eugenia; Connell, Shea P; Smith, Ian P; Duffin, Rodger; Boere, John A F; Heusinkveld, Harm J; Albrecht, Catrin; de Jong, Wim H; Cassee, Flemming R
Abstract:
Development and manufacture of nanomaterials is growing at an exponential rate, despite an incomplete understanding of how their physicochemical characteristics affect their potential toxicity. Redox activity has been suggested to be an important physicochemical property of nanomaterials to predict their biological activity. This study assessed the influence of redox activity by modification of cerium dioxide nanoparticles (CeO2 NPs) via zirconium (Zr) doping on the biodistribution, pulmonary and cardiovascular effects in mice following inhalation. Healthy mice (C57BL/6 J), mice prone to cardiovascular disease (ApoE-/-, western-diet fed) and a mouse model of neurological disease (5 × FAD) were exposed via nose-only inhalation to CeO2 NPs with varying amounts of Zr-doping (0%, 27% or 78% Zr), or clean air, over a four-week period (4 mg/m3 for 3 h/day, 5 days/week). Effects were assessed four weeks post-exposure. In all three mouse models CeO2 NP exposure had no major toxicological effects apart from some modest inflammatory histopathology in the lung, which was not related to the amount of Zr-doping. In ApoE-/- mice CeO2 did not change the size of atherosclerotic plaques, but there was a trend towards increased inflammatory cell content in relation to the Zr content of the CeO2 NPs. These findings show that subacute inhalation of CeO2 NPs causes minimal pulmonary and cardiovascular effect four weeks post-exposure and that Zr-doping of CeO2 NPs has limited effect on these responses. Further studies with nanomaterials with a higher inherent toxicity or a broader range of redox activities are needed to fully assess the influence of redox activity on the toxicity of nanomaterials.
Citation:
The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation. 2017, 11 (6):794-808 Nanotoxicology
Journal:
Nanotoxicology 2017, 11(6):794-808
Issue Date:
Aug-2017
URI:
http://hdl.handle.net/10029/621043
DOI:
10.1080/17435390.2017.1357214
PubMed ID:
28741972
Type:
Article
Language:
en
ISSN:
1743-5404
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorDekkers, Susanen
dc.contributor.authorMiller, Mark Ren
dc.contributor.authorSchins, Roel P Fen
dc.contributor.authorRömer, Isabellaen
dc.contributor.authorRuss, Mikeen
dc.contributor.authorVandebriel, Rob Jen
dc.contributor.authorLynch, Iseulten
dc.contributor.authorBelinga-Desaunay, Marie-Franceen
dc.contributor.authorValsami-Jones, Eugeniaen
dc.contributor.authorConnell, Shea Pen
dc.contributor.authorSmith, Ian Pen
dc.contributor.authorDuffin, Rodgeren
dc.contributor.authorBoere, John A Fen
dc.contributor.authorHeusinkveld, Harm Jen
dc.contributor.authorAlbrecht, Catrinen
dc.contributor.authorde Jong, Wim Hen
dc.contributor.authorCassee, Flemming Ren
dc.date.accessioned2018-01-09T09:20:11Z-
dc.date.available2018-01-09T09:20:11Z-
dc.date.issued2017-08-
dc.identifier.citationThe effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation. 2017, 11 (6):794-808 Nanotoxicologyen
dc.identifier.issn1743-5404-
dc.identifier.pmid28741972-
dc.identifier.doi10.1080/17435390.2017.1357214-
dc.identifier.urihttp://hdl.handle.net/10029/621043-
dc.description.abstractDevelopment and manufacture of nanomaterials is growing at an exponential rate, despite an incomplete understanding of how their physicochemical characteristics affect their potential toxicity. Redox activity has been suggested to be an important physicochemical property of nanomaterials to predict their biological activity. This study assessed the influence of redox activity by modification of cerium dioxide nanoparticles (CeO2 NPs) via zirconium (Zr) doping on the biodistribution, pulmonary and cardiovascular effects in mice following inhalation. Healthy mice (C57BL/6 J), mice prone to cardiovascular disease (ApoE-/-, western-diet fed) and a mouse model of neurological disease (5 × FAD) were exposed via nose-only inhalation to CeO2 NPs with varying amounts of Zr-doping (0%, 27% or 78% Zr), or clean air, over a four-week period (4 mg/m3 for 3 h/day, 5 days/week). Effects were assessed four weeks post-exposure. In all three mouse models CeO2 NP exposure had no major toxicological effects apart from some modest inflammatory histopathology in the lung, which was not related to the amount of Zr-doping. In ApoE-/- mice CeO2 did not change the size of atherosclerotic plaques, but there was a trend towards increased inflammatory cell content in relation to the Zr content of the CeO2 NPs. These findings show that subacute inhalation of CeO2 NPs causes minimal pulmonary and cardiovascular effect four weeks post-exposure and that Zr-doping of CeO2 NPs has limited effect on these responses. Further studies with nanomaterials with a higher inherent toxicity or a broader range of redox activities are needed to fully assess the influence of redox activity on the toxicity of nanomaterials.en
dc.language.isoenen
dc.rightsArchived with thanks to Nanotoxicologyen
dc.subject.meshAnimals-
dc.subject.meshCardiovascular System-
dc.subject.meshCerium-
dc.subject.meshInhalation Exposure-
dc.subject.meshLung-
dc.subject.meshMice-
dc.subject.meshMice, Inbred C57BL-
dc.subject.meshMice, Knockout, ApoE-
dc.subject.meshNanoparticles-
dc.subject.meshOxidation-Reduction-
dc.subject.meshPlaque, Atherosclerotic-
dc.subject.meshTissue Distribution-
dc.subject.meshZirconium-
dc.titleThe effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation.en
dc.typeArticleen
dc.identifier.journalNanotoxicology 2017, 11(6):794-808en

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