Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621049
Title:
Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.
Authors:
Carayol, Marion; Leitzmann, Michael F; Ferrari, Pietro; Zamora-Ros, Raul; Achaintre, David; Stepien, Magdalena; Schmidt, Julie A; Travis, Ruth C; Overvad, Kim; Tjønneland, Anne; Hansen, Louise; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Bachlechner, Ursula; Trichopoulou, Antonia; Bamia, Christina; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Quirós, J Ramón; Sánchez-Cantalejo, Emilio; Huerta, José María; Ardanaz, Eva; Arriola, Larraitz; Agudo, Antonio; Nilsson, Jan; Melander, Olle; Bueno-de-Mesquita, Bas; Peeters, Petra H; Wareham, Nick; Khaw, Kay-Tee; Jenab, Mazda; Key, Timothy J; Scalbert, Augustin; Rinaldi, Sabina
Abstract:
Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.
Citation:
Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort. 2017, 16 (9):3137-3146 J. Proteome Res.
Journal:
J Proteome Res 2017, 16(9):3137-46
Issue Date:
1-Sep-2017
URI:
http://hdl.handle.net/10029/621049
DOI:
10.1021/acs.jproteome.6b01062
PubMed ID:
28758405
Type:
Article
Language:
en
ISSN:
1535-3907
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorCarayol, Marionen
dc.contributor.authorLeitzmann, Michael Fen
dc.contributor.authorFerrari, Pietroen
dc.contributor.authorZamora-Ros, Raulen
dc.contributor.authorAchaintre, Daviden
dc.contributor.authorStepien, Magdalenaen
dc.contributor.authorSchmidt, Julie Aen
dc.contributor.authorTravis, Ruth Cen
dc.contributor.authorOvervad, Kimen
dc.contributor.authorTjønneland, Anneen
dc.contributor.authorHansen, Louiseen
dc.contributor.authorKaaks, Rudolfen
dc.contributor.authorKühn, Tilmanen
dc.contributor.authorBoeing, Heineren
dc.contributor.authorBachlechner, Ursulaen
dc.contributor.authorTrichopoulou, Antoniaen
dc.contributor.authorBamia, Christinaen
dc.contributor.authorPalli, Domenicoen
dc.contributor.authorAgnoli, Claudiaen
dc.contributor.authorTumino, Rosarioen
dc.contributor.authorVineis, Paoloen
dc.contributor.authorPanico, Salvatoreen
dc.contributor.authorQuirós, J Ramónen
dc.contributor.authorSánchez-Cantalejo, Emilioen
dc.contributor.authorHuerta, José Maríaen
dc.contributor.authorArdanaz, Evaen
dc.contributor.authorArriola, Larraitzen
dc.contributor.authorAgudo, Antonioen
dc.contributor.authorNilsson, Janen
dc.contributor.authorMelander, Olleen
dc.contributor.authorBueno-de-Mesquita, Basen
dc.contributor.authorPeeters, Petra Hen
dc.contributor.authorWareham, Nicken
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorJenab, Mazdaen
dc.contributor.authorKey, Timothy Jen
dc.contributor.authorScalbert, Augustinen
dc.contributor.authorRinaldi, Sabinaen
dc.date.accessioned2018-01-09T09:42:16Z-
dc.date.available2018-01-09T09:42:16Z-
dc.date.issued2017-09-01-
dc.identifier.citationBlood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort. 2017, 16 (9):3137-3146 J. Proteome Res.en
dc.identifier.issn1535-3907-
dc.identifier.pmid28758405-
dc.identifier.doi10.1021/acs.jproteome.6b01062-
dc.identifier.urihttp://hdl.handle.net/10029/621049-
dc.description.abstractMetabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.en
dc.language.isoenen
dc.rightsArchived with thanks to Journal of proteome researchen
dc.titleBlood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.en
dc.typeArticleen
dc.identifier.journalJ Proteome Res 2017, 16(9):3137-46en

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