Primary Human Influenza B Virus Infection Induces Cross-Lineage Hemagglutinin Stalk-Specific Antibodies Mediating Antibody-Dependent Cellular Cytoxicity.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621146
Title:
Primary Human Influenza B Virus Infection Induces Cross-Lineage Hemagglutinin Stalk-Specific Antibodies Mediating Antibody-Dependent Cellular Cytoxicity.
Authors:
de Vries, Rory D; Nieuwkoop, Nella J; van der Klis, Fiona R M; Koopmans, Marion P G; Krammer, Florian; Rimmelzwaan, Guus F
Abstract:
Influenza A virus (IAV) and influenza B virus (IBV) cause substantial morbidity and mortality during annual epidemics. Two distinct lineages of IBV are distinguished, based on variation in hemagglutinin (HA): B/Victoria/2/87-like (B/Vic) and B/Yamagata/16/88-like (B/Yam). Here, we show that, in humans, primary IBV infection with either lineage induces HA-specific antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies. IBV infection induced antibodies specific to the HA head and stalk, but only HA stalk-specific antibodies mediated ADCC efficiently and displayed cross-reactivity with IBV of both lineages. This corresponds to recent findings that 2 points of contact between the effector and target cell (ie, HA and sialic acid, respectively, and the fragment crystallizable [Fc] domain and Fcγ receptor IIIα, respectively) are required for efficient ADCC activity and that antibodies specific for the receptor-binding site located in the head domain of HA therefore fail to mediate ADCC. Potentially, ADCC-mediating antibodies directed to the HA stalk of IBV contribute to cross-protective immunity to IBV of both lineages.
Citation:
Primary Human Influenza B Virus Infection Induces Cross-Lineage Hemagglutinin Stalk-Specific Antibodies Mediating Antibody-Dependent Cellular Cytoxicity. 2017, 217 (1):3-11 J. Infect. Dis.
Journal:
J Infect Dis 2017; 217(1):3-11
Issue Date:
27-Dec-2017
URI:
http://hdl.handle.net/10029/621146
DOI:
10.1093/infdis/jix546
PubMed ID:
29294018
Language:
en
ISSN:
1537-6613
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorde Vries, Rory Den
dc.contributor.authorNieuwkoop, Nella Jen
dc.contributor.authorvan der Klis, Fiona R Men
dc.contributor.authorKoopmans, Marion P Gen
dc.contributor.authorKrammer, Florianen
dc.contributor.authorRimmelzwaan, Guus Fen
dc.date.accessioned2018-01-12T08:49:53Z-
dc.date.available2018-01-12T08:49:53Z-
dc.date.issued2017-12-27-
dc.identifier.citationPrimary Human Influenza B Virus Infection Induces Cross-Lineage Hemagglutinin Stalk-Specific Antibodies Mediating Antibody-Dependent Cellular Cytoxicity. 2017, 217 (1):3-11 J. Infect. Dis.en
dc.identifier.issn1537-6613-
dc.identifier.pmid29294018-
dc.identifier.doi10.1093/infdis/jix546-
dc.identifier.urihttp://hdl.handle.net/10029/621146-
dc.description.abstractInfluenza A virus (IAV) and influenza B virus (IBV) cause substantial morbidity and mortality during annual epidemics. Two distinct lineages of IBV are distinguished, based on variation in hemagglutinin (HA): B/Victoria/2/87-like (B/Vic) and B/Yamagata/16/88-like (B/Yam). Here, we show that, in humans, primary IBV infection with either lineage induces HA-specific antibody-dependent cellular cytotoxicity (ADCC)-mediating antibodies. IBV infection induced antibodies specific to the HA head and stalk, but only HA stalk-specific antibodies mediated ADCC efficiently and displayed cross-reactivity with IBV of both lineages. This corresponds to recent findings that 2 points of contact between the effector and target cell (ie, HA and sialic acid, respectively, and the fragment crystallizable [Fc] domain and Fcγ receptor IIIα, respectively) are required for efficient ADCC activity and that antibodies specific for the receptor-binding site located in the head domain of HA therefore fail to mediate ADCC. Potentially, ADCC-mediating antibodies directed to the HA stalk of IBV contribute to cross-protective immunity to IBV of both lineages.en
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titlePrimary Human Influenza B Virus Infection Induces Cross-Lineage Hemagglutinin Stalk-Specific Antibodies Mediating Antibody-Dependent Cellular Cytoxicity.en
dc.identifier.journalJ Infect Dis 2017; 217(1):3-11en

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