Mechanisms of bacterial resistance to antimicrobial agents.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621153
Title:
Mechanisms of bacterial resistance to antimicrobial agents.
Authors:
van Duijkeren, Engeline; Schink, Anne-Kathrin; Roberts, Marilyn C; Wang, Yang; Schwarz, Stefan
Abstract:
During the past decades resistance to virtually all antimicrobial agents has been observed in bacteria of animal origin. This chapter describes in detail the mechanisms so far encountered for the various classes of antimicrobial agents. The main mechanisms include enzymatic inactivation by either disintegration or chemical modification of antimicrobial agents, reduced intracellular accumulation by either decreased influx or increased efflux of antimicrobial agents, and modifications at the cellular target sites (i.e., mutational changes, chemical modification, protection, or even replacement of the target sites). Often several mechanisms interact to enhance bacterial resistance to antimicrobial agents. This is a completely revised version of the corresponding chapter in the book Antimicrobial Resistance in Bacteria of Animal Origin published in 2006. New sections have been added for oxazolidinones, polypeptides, mupirocin, ansamycins, fosfomycin, fusidic acid, and streptomycins, and the chapters for the remaining classes of antimicrobial agents have been completely updated to cover the advances in knowledge gained since 2006.
Citation:
Mechanisms of Bacterial Resistance to Antimicrobial Agents. 2018, 6 (1) Microbiol Spectr
Journal:
Microbiol Spectr 2018; 6(1)
Issue Date:
Jan-2018
URI:
http://hdl.handle.net/10029/621153
DOI:
10.1128/microbiolspec.ARBA-0019-2017
PubMed ID:
29327680
Type:
Article
Language:
en
ISSN:
2165-0497
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorvan Duijkeren, Engelineen
dc.contributor.authorSchink, Anne-Kathrinen
dc.contributor.authorRoberts, Marilyn Cen
dc.contributor.authorWang, Yangen
dc.contributor.authorSchwarz, Stefanen
dc.date.accessioned2018-01-16T09:00:47Z-
dc.date.available2018-01-16T09:00:47Z-
dc.date.issued2018-01-
dc.identifier.citationMechanisms of Bacterial Resistance to Antimicrobial Agents. 2018, 6 (1) Microbiol Spectren
dc.identifier.issn2165-0497-
dc.identifier.pmid29327680-
dc.identifier.doi10.1128/microbiolspec.ARBA-0019-2017-
dc.identifier.urihttp://hdl.handle.net/10029/621153-
dc.description.abstractDuring the past decades resistance to virtually all antimicrobial agents has been observed in bacteria of animal origin. This chapter describes in detail the mechanisms so far encountered for the various classes of antimicrobial agents. The main mechanisms include enzymatic inactivation by either disintegration or chemical modification of antimicrobial agents, reduced intracellular accumulation by either decreased influx or increased efflux of antimicrobial agents, and modifications at the cellular target sites (i.e., mutational changes, chemical modification, protection, or even replacement of the target sites). Often several mechanisms interact to enhance bacterial resistance to antimicrobial agents. This is a completely revised version of the corresponding chapter in the book Antimicrobial Resistance in Bacteria of Animal Origin published in 2006. New sections have been added for oxazolidinones, polypeptides, mupirocin, ansamycins, fosfomycin, fusidic acid, and streptomycins, and the chapters for the remaining classes of antimicrobial agents have been completely updated to cover the advances in knowledge gained since 2006.en
dc.language.isoenen
dc.rightsArchived with thanks to Microbiology spectrumen
dc.titleMechanisms of bacterial resistance to antimicrobial agents.en
dc.typeArticleen
dc.identifier.journalMicrobiol Spectr 2018; 6(1)en

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