Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: 'Aethiops vetus'.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621332
Title:
Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: 'Aethiops vetus'.
Authors:
Nebenzahl-Guimaraes, Hanna; Yimer, Solomon A; Holm-Hansen, Carol; de Beer, Jessica; Brosch, Roland; van Soolingen, Dick
Abstract:
Lineage 7 of the Mycobacterium tuberculosis complex has recently been identified among strains originating from Ethiopia. Using different DNA typing techniques, this study provides additional information on the genetic heterogeneity of five lineage 7 strains collected in the Amhara Region of Ethiopia. It also confirms the phylogenetic positioning of these strains between the ancient lineage 1 and TbD1-deleted, modern lineages 2, 3 and 4 of Mycobacterium tuberculosis. Four newly identified large sequence polymorphisms characteristic of the Amhara Region lineage 7 strains are described. While lineage 7 strains have been previously identified in the Woldiya area, we show that lineage 7 strains circulate in other parts of the Amhara Region and also among foreign-born individuals from Eritrea and Somalia in The Netherlands. For ease of documenting future identification of these strains in other geographical locations and recognizing the place of origin, we propose to assign lineage 7 strains the lineage name 'Aethiops vetus'.
Citation:
Genomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: 'Aethiops vetus'. 2016, 2 (6):e000063 Microb Genom
Journal:
Microb Genom 2016; 2(6):e000063
Issue Date:
Jun-2016
URI:
http://hdl.handle.net/10029/621332
DOI:
10.1099/mgen.0.000063
PubMed ID:
28348856
Type:
Article
Language:
en
ISSN:
2057-5858
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorNebenzahl-Guimaraes, Hannaen
dc.contributor.authorYimer, Solomon Aen
dc.contributor.authorHolm-Hansen, Carolen
dc.contributor.authorde Beer, Jessicaen
dc.contributor.authorBrosch, Rolanden
dc.contributor.authorvan Soolingen, Dicken
dc.date.accessioned2018-02-07T07:41:31Z-
dc.date.available2018-02-07T07:41:31Z-
dc.date.issued2016-06-
dc.identifier.citationGenomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: 'Aethiops vetus'. 2016, 2 (6):e000063 Microb Genomen
dc.identifier.issn2057-5858-
dc.identifier.pmid28348856-
dc.identifier.doi10.1099/mgen.0.000063-
dc.identifier.urihttp://hdl.handle.net/10029/621332-
dc.description.abstractLineage 7 of the Mycobacterium tuberculosis complex has recently been identified among strains originating from Ethiopia. Using different DNA typing techniques, this study provides additional information on the genetic heterogeneity of five lineage 7 strains collected in the Amhara Region of Ethiopia. It also confirms the phylogenetic positioning of these strains between the ancient lineage 1 and TbD1-deleted, modern lineages 2, 3 and 4 of Mycobacterium tuberculosis. Four newly identified large sequence polymorphisms characteristic of the Amhara Region lineage 7 strains are described. While lineage 7 strains have been previously identified in the Woldiya area, we show that lineage 7 strains circulate in other parts of the Amhara Region and also among foreign-born individuals from Eritrea and Somalia in The Netherlands. For ease of documenting future identification of these strains in other geographical locations and recognizing the place of origin, we propose to assign lineage 7 strains the lineage name 'Aethiops vetus'.en
dc.language.isoenen
dc.rightsArchived with thanks to Microbial genomicsen
dc.titleGenomic characterization of Mycobacterium tuberculosis lineage 7 and a proposed name: 'Aethiops vetus'.en
dc.typeArticleen
dc.identifier.journalMicrob Genom 2016; 2(6):e000063en

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