Biokinetics of Nanomaterials: the Role of Biopersistence.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621333
Title:
Biokinetics of Nanomaterials: the Role of Biopersistence.
Authors:
Laux, Peter; Riebeling, Christian; Booth, Andy M; Brain, Joseph D; Brunner, Josephine; Cerrillo, Cristina; Creutzenberg, Otto; Estrela-Lopis, Irina; Gebel, Thomas; Johanson, Gunnar; Jungnickel, Harald; Kock, Heiko; Tentschert, Jutta; Tlili, Ahmed; Schäffer, Andreas; Sips, Adriënne J A M; Yokel, Robert A; Luch, Andreas
Abstract:
Nanotechnology risk management strategies and environmental regulations continue to rely on hazard and exposure assessment protocols developed for bulk materials, including larger size particles, while commercial application of nanomaterials (NMs) increases. In order to support and corroborate risk assessment of NMs for workers, consumers, and the environment it is crucial to establish the impact of biopersistence of NMs at realistic doses. In the future, such data will allow a more refined future categorization of NMs. Despite many experiments on NM characterization and numerous in vitro and in vivo studies, several questions remain unanswered including the influence of biopersistence on the toxicity of NMs. It is unclear which criteria to apply to characterize a NM as biopersistent. Detection and quantification of NMs, especially determination of their state, i.e., dissolution, aggregation, and agglomeration within biological matrices and other environments are still challenging tasks; moreover mechanisms of nanoparticle (NP) translocation and persistence remain critical gaps. This review summarizes the current understanding of NM biokinetics focusing on determinants of biopersistence. Thorough particle characterization in different exposure scenarios and biological matrices requires use of suitable analytical methods and is a prerequisite to understand biopersistence and for the development of appropriate dosimetry. Analytical tools that potentially can facilitate elucidation of key NM characteristics, such as ion beam microscopy (IBM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), are discussed in relation to their potential to advance the understanding of biopersistent NM kinetics. We conclude that a major requirement for future nanosafety research is the development and application of analytical tools to characterize NPs in different exposure scenarios and biological matrices.
Citation:
Biokinetics of Nanomaterials: the Role of Biopersistence. 2017, 6:69-80 NanoImpact
Journal:
NanoImpact 2017; 6:69-80
Issue Date:
Apr-2017
URI:
http://hdl.handle.net/10029/621333
DOI:
10.1016/j.impact.2017.03.003
PubMed ID:
29057373
Type:
Article
Language:
en
ISSN:
2452-0748
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorLaux, Peteren
dc.contributor.authorRiebeling, Christianen
dc.contributor.authorBooth, Andy Men
dc.contributor.authorBrain, Joseph Den
dc.contributor.authorBrunner, Josephineen
dc.contributor.authorCerrillo, Cristinaen
dc.contributor.authorCreutzenberg, Ottoen
dc.contributor.authorEstrela-Lopis, Irinaen
dc.contributor.authorGebel, Thomasen
dc.contributor.authorJohanson, Gunnaren
dc.contributor.authorJungnickel, Haralden
dc.contributor.authorKock, Heikoen
dc.contributor.authorTentschert, Juttaen
dc.contributor.authorTlili, Ahmeden
dc.contributor.authorSchäffer, Andreasen
dc.contributor.authorSips, Adriënne J A Men
dc.contributor.authorYokel, Robert Aen
dc.contributor.authorLuch, Andreasen
dc.date.accessioned2018-02-07T07:44:04Z-
dc.date.available2018-02-07T07:44:04Z-
dc.date.issued2017-04-
dc.identifier.citationBiokinetics of Nanomaterials: the Role of Biopersistence. 2017, 6:69-80 NanoImpacten
dc.identifier.issn2452-0748-
dc.identifier.pmid29057373-
dc.identifier.doi10.1016/j.impact.2017.03.003-
dc.identifier.urihttp://hdl.handle.net/10029/621333-
dc.description.abstractNanotechnology risk management strategies and environmental regulations continue to rely on hazard and exposure assessment protocols developed for bulk materials, including larger size particles, while commercial application of nanomaterials (NMs) increases. In order to support and corroborate risk assessment of NMs for workers, consumers, and the environment it is crucial to establish the impact of biopersistence of NMs at realistic doses. In the future, such data will allow a more refined future categorization of NMs. Despite many experiments on NM characterization and numerous in vitro and in vivo studies, several questions remain unanswered including the influence of biopersistence on the toxicity of NMs. It is unclear which criteria to apply to characterize a NM as biopersistent. Detection and quantification of NMs, especially determination of their state, i.e., dissolution, aggregation, and agglomeration within biological matrices and other environments are still challenging tasks; moreover mechanisms of nanoparticle (NP) translocation and persistence remain critical gaps. This review summarizes the current understanding of NM biokinetics focusing on determinants of biopersistence. Thorough particle characterization in different exposure scenarios and biological matrices requires use of suitable analytical methods and is a prerequisite to understand biopersistence and for the development of appropriate dosimetry. Analytical tools that potentially can facilitate elucidation of key NM characteristics, such as ion beam microscopy (IBM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), are discussed in relation to their potential to advance the understanding of biopersistent NM kinetics. We conclude that a major requirement for future nanosafety research is the development and application of analytical tools to characterize NPs in different exposure scenarios and biological matrices.en
dc.language.isoenen
dc.rightsArchived with thanks to NanoImpacten
dc.titleBiokinetics of Nanomaterials: the Role of Biopersistence.en
dc.typeArticleen
dc.identifier.journalNanoImpact 2017; 6:69-80en

Related articles on PubMed

All Items in WARP are protected by copyright, with all rights reserved, unless otherwise indicated.