Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621343
Title:
Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination.
Authors:
van der Lee, Saskia; Kemmeren, Jeanet M; de Rond, Lia G H; Öztürk, Kemal; Westerhof, Anneke; de Melker, Hester E; Sanders, Elisabeth A M; Berbers, Guy A M; van der Maas, Nicoline A T; Rümke, Hans C; Buisman, Anne-Marie
Abstract:
In the Netherlands, acellular pertussis vaccines replaced the more reactogenic whole-cell pertussis vaccines. This replacement in the primary immunization schedule of infants coincided with a significant increase in pronounced local adverse events (AEs) in 4 years old children shortly after the administration of a fifth diphtheria, tetanus, acellular pertussis and inactivated polio (DTaP-IPV) vaccine. The objective of this study was to investigate possible differences in vaccine antigen-specific immune responses between children with and without a pronounced local AE after the fifth DTaP-IPV vaccination.
Citation:
Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination. 2017, 36 (9):e223-e229 Pediatr. Infect. Dis. J.
Journal:
Pediatr Infect Dis J 2017; 36(9):e223-9
Issue Date:
Sep-2017
URI:
http://hdl.handle.net/10029/621343
DOI:
10.1097/INF.0000000000001620
PubMed ID:
28430750
Type:
Article
Language:
en
ISSN:
1532-0987
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorvan der Lee, Saskiaen
dc.contributor.authorKemmeren, Jeanet Men
dc.contributor.authorde Rond, Lia G Hen
dc.contributor.authorÖztürk, Kemalen
dc.contributor.authorWesterhof, Annekeen
dc.contributor.authorde Melker, Hester Een
dc.contributor.authorSanders, Elisabeth A Men
dc.contributor.authorBerbers, Guy A Men
dc.contributor.authorvan der Maas, Nicoline A Ten
dc.contributor.authorRümke, Hans Cen
dc.contributor.authorBuisman, Anne-Marieen
dc.date.accessioned2018-02-07T08:02:58Z-
dc.date.available2018-02-07T08:02:58Z-
dc.date.issued2017-09-
dc.identifier.citationElevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination. 2017, 36 (9):e223-e229 Pediatr. Infect. Dis. J.en
dc.identifier.issn1532-0987-
dc.identifier.pmid28430750-
dc.identifier.doi10.1097/INF.0000000000001620-
dc.identifier.urihttp://hdl.handle.net/10029/621343-
dc.description.abstractIn the Netherlands, acellular pertussis vaccines replaced the more reactogenic whole-cell pertussis vaccines. This replacement in the primary immunization schedule of infants coincided with a significant increase in pronounced local adverse events (AEs) in 4 years old children shortly after the administration of a fifth diphtheria, tetanus, acellular pertussis and inactivated polio (DTaP-IPV) vaccine. The objective of this study was to investigate possible differences in vaccine antigen-specific immune responses between children with and without a pronounced local AE after the fifth DTaP-IPV vaccination.en
dc.language.isoenen
dc.rightsArchived with thanks to The Pediatric infectious disease journalen
dc.subject.meshAntibodies, Bacterial-
dc.subject.meshAntigens, Bacterial-
dc.subject.meshCase-Control Studies-
dc.subject.meshCells, Cultured-
dc.subject.meshChild, Preschool-
dc.subject.meshCytokines-
dc.subject.meshDiphtheria-Tetanus-acellular Pertussis Vaccines-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunization, Secondary-
dc.subject.meshImmunoglobulin G-
dc.subject.meshInflammation-
dc.subject.meshLeukocytes, Mononuclear-
dc.subject.meshMale-
dc.subject.meshNetherlands-
dc.titleElevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination.en
dc.typeArticleen
dc.identifier.journalPediatr Infect Dis J 2017; 36(9):e223-9en

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