Livestock-associated risk factors for pneumonia in an area of intensive animal farming in the Netherlands.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621345
Title:
Livestock-associated risk factors for pneumonia in an area of intensive animal farming in the Netherlands.
Authors:
Freidl, Gudrun S; Spruijt, Ineke T; Borlée, Floor; Smit, Lidwien A M; van Gageldonk-Lafeber, Arianne B; Heederik, Dick J J; Yzermans, Joris; van Dijk, Christel E; Maassen, Catharina B M; van der Hoek, Wim
Abstract:
Previous research conducted in 2009 found a significant positive association between pneumonia in humans and living close to goat and poultry farms. However, as this result might have been affected by a large goat-related Q fever epidemic, the aim of the current study was to re-evaluate this association, now that the Q-fever epidemic had ended. In 2014/15, 2,494 adults (aged 20-72 years) living in a livestock-dense area in the Netherlands participated in a medical examination and completed a questionnaire on respiratory health, lifestyle and other items. We retrieved additional information for 2,426/2,494 (97%) participants from electronic medical records (EMR) from general practitioners. The outcome was self-reported, physician-diagnosed pneumonia or pneumonia recorded in the EMR in the previous three years. Livestock license data was used to determine exposure to livestock. We quantified associations between livestock exposures and pneumonia using odds ratios adjusted for participant characteristics and comorbidities (aOR). The three-year cumulative frequency of pneumonia was 186/2,426 (7.7%). Residents within 2,000m of a farm with at least 50 goats had an increased risk of pneumonia, which increased the closer they lived to the farm (2,000m aOR 1.9, 95% CI 1.4-2.6; 500m aOR 4.4, 95% CI 2.0-9.8). We found no significant associations between exposure to other farm animals and pneumonia. However, when conducting sensitivity analyses using pneumonia outcome based on EMR only, we found a weak but statistically significant association with presence of a poultry farm within 1,000m (aOR: 1.7, 95% CI 1.1-2.7). Living close to goat and poultry farms still constitute risk factors for pneumonia. Individuals with pneumonia were not more often seropositive for Coxiella burnetii, indicating that results are not explained by Q fever. We strongly recommend identification of pneumonia causes by the use of molecular diagnostics and investigating the role of non-infectious agents such as particulate matter or endotoxins.
Citation:
Livestock-associated risk factors for pneumonia in an area of intensive animal farming in the Netherlands. 2017, 12 (3):e0174796 PLoS ONE
Journal:
Plos One 2017; 12(3)e0174796
Issue Date:
2017
URI:
http://hdl.handle.net/10029/621345
DOI:
10.1371/journal.pone.0174796
PubMed ID:
28362816
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorFreidl, Gudrun Sen
dc.contributor.authorSpruijt, Ineke Ten
dc.contributor.authorBorlée, Flooren
dc.contributor.authorSmit, Lidwien A Men
dc.contributor.authorvan Gageldonk-Lafeber, Arianne Ben
dc.contributor.authorHeederik, Dick J Jen
dc.contributor.authorYzermans, Jorisen
dc.contributor.authorvan Dijk, Christel Een
dc.contributor.authorMaassen, Catharina B Men
dc.contributor.authorvan der Hoek, Wimen
dc.date.accessioned2018-02-07T08:06:17Z-
dc.date.available2018-02-07T08:06:17Z-
dc.date.issued2017-
dc.identifier.citationLivestock-associated risk factors for pneumonia in an area of intensive animal farming in the Netherlands. 2017, 12 (3):e0174796 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid28362816-
dc.identifier.doi10.1371/journal.pone.0174796-
dc.identifier.urihttp://hdl.handle.net/10029/621345-
dc.description.abstractPrevious research conducted in 2009 found a significant positive association between pneumonia in humans and living close to goat and poultry farms. However, as this result might have been affected by a large goat-related Q fever epidemic, the aim of the current study was to re-evaluate this association, now that the Q-fever epidemic had ended. In 2014/15, 2,494 adults (aged 20-72 years) living in a livestock-dense area in the Netherlands participated in a medical examination and completed a questionnaire on respiratory health, lifestyle and other items. We retrieved additional information for 2,426/2,494 (97%) participants from electronic medical records (EMR) from general practitioners. The outcome was self-reported, physician-diagnosed pneumonia or pneumonia recorded in the EMR in the previous three years. Livestock license data was used to determine exposure to livestock. We quantified associations between livestock exposures and pneumonia using odds ratios adjusted for participant characteristics and comorbidities (aOR). The three-year cumulative frequency of pneumonia was 186/2,426 (7.7%). Residents within 2,000m of a farm with at least 50 goats had an increased risk of pneumonia, which increased the closer they lived to the farm (2,000m aOR 1.9, 95% CI 1.4-2.6; 500m aOR 4.4, 95% CI 2.0-9.8). We found no significant associations between exposure to other farm animals and pneumonia. However, when conducting sensitivity analyses using pneumonia outcome based on EMR only, we found a weak but statistically significant association with presence of a poultry farm within 1,000m (aOR: 1.7, 95% CI 1.1-2.7). Living close to goat and poultry farms still constitute risk factors for pneumonia. Individuals with pneumonia were not more often seropositive for Coxiella burnetii, indicating that results are not explained by Q fever. We strongly recommend identification of pneumonia causes by the use of molecular diagnostics and investigating the role of non-infectious agents such as particulate matter or endotoxins.en
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAnimal Husbandry-
dc.subject.meshAnimals-
dc.subject.meshAnimals, Domestic-
dc.subject.meshCoxiella burnetii-
dc.subject.meshElectronic Health Records-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLivestock-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNetherlands-
dc.subject.meshPneumonia-
dc.subject.meshQ Fever-
dc.subject.meshRisk Factors-
dc.subject.meshYoung Adult-
dc.titleLivestock-associated risk factors for pneumonia in an area of intensive animal farming in the Netherlands.en
dc.typeArticleen
dc.identifier.journalPlos One 2017; 12(3)e0174796en

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