Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621657
Title:
Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.
Authors:
van Duijnhoven, Fränzel J B; Jenab, Mazda; Hveem, Kristian; Siersema, Peter D; Fedirko, Veronika; Duell, Eric J; Kampman, Ellen; Halfweeg, Anouk; van Kranen, Henk J; van den Ouweland, Jody M W; Weiderpass, Elisabete; Murphy, Neil; Langhammer, Arnulf; Ness-Jensen, Eivind; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Cadeau, Claire; Kvaskoff, Marina; Boutron-Ruault, Marie-Christine; Katzke, Verena A; Kühn, Tilman; Boeing, Heiner; Trichopoulou, Antonia; Kotanidou, Anastasia; Kritikou, Maria; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Panico, Salvatore; Matullo, Giuseppe; Peeters, Petra; Brustad, Magritt; Olsen, Karina Standahl; Lasheras, Cristina; Obón-Santacana, Mireia; Sánchez, María-José; Dorronsoro, Miren; Chirlaque, Maria-Dolores; Barricarte, Aurelio; Manjer, Jonas; Almquist, Martin; Renström, Frida; Ye, Weimin; Wareham, Nick; Khaw, Kay-Tee; Bradbury, Kathryn E; Freisling, Heinz; Aune, Dagfinn; Norat, Teresa; Riboli, Elio; Bueno-de-Mesquita, H B As
Abstract:
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2and 25(OH)D3combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
Citation:
Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations. 2018, 142 (6):1189-1201 Int. J. Cancer
Journal:
Int J Cancer 2018; 142(6):1189-1201
Issue Date:
15-Mar-2018
URI:
http://hdl.handle.net/10029/621657
DOI:
10.1002/ijc.31146
PubMed ID:
29114875
Type:
Article
Language:
en
ISSN:
1097-0215
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorvan Duijnhoven, Fränzel J Ben
dc.contributor.authorJenab, Mazdaen
dc.contributor.authorHveem, Kristianen
dc.contributor.authorSiersema, Peter Den
dc.contributor.authorFedirko, Veronikaen
dc.contributor.authorDuell, Eric Jen
dc.contributor.authorKampman, Ellenen
dc.contributor.authorHalfweeg, Anouken
dc.contributor.authorvan Kranen, Henk Jen
dc.contributor.authorvan den Ouweland, Jody M Wen
dc.contributor.authorWeiderpass, Elisabeteen
dc.contributor.authorMurphy, Neilen
dc.contributor.authorLanghammer, Arnulfen
dc.contributor.authorNess-Jensen, Eivinden
dc.contributor.authorOlsen, Anjaen
dc.contributor.authorTjønneland, Anneen
dc.contributor.authorOvervad, Kimen
dc.contributor.authorCadeau, Claireen
dc.contributor.authorKvaskoff, Marinaen
dc.contributor.authorBoutron-Ruault, Marie-Christineen
dc.contributor.authorKatzke, Verena Aen
dc.contributor.authorKühn, Tilmanen
dc.contributor.authorBoeing, Heineren
dc.contributor.authorTrichopoulou, Antoniaen
dc.contributor.authorKotanidou, Anastasiaen
dc.contributor.authorKritikou, Mariaen
dc.contributor.authorPalli, Domenicoen
dc.contributor.authorAgnoli, Claudiaen
dc.contributor.authorTumino, Rosarioen
dc.contributor.authorPanico, Salvatoreen
dc.contributor.authorMatullo, Giuseppeen
dc.contributor.authorPeeters, Petraen
dc.contributor.authorBrustad, Magritten
dc.contributor.authorOlsen, Karina Standahlen
dc.contributor.authorLasheras, Cristinaen
dc.contributor.authorObón-Santacana, Mireiaen
dc.contributor.authorSánchez, María-Joséen
dc.contributor.authorDorronsoro, Mirenen
dc.contributor.authorChirlaque, Maria-Doloresen
dc.contributor.authorBarricarte, Aurelioen
dc.contributor.authorManjer, Jonasen
dc.contributor.authorAlmquist, Martinen
dc.contributor.authorRenström, Fridaen
dc.contributor.authorYe, Weiminen
dc.contributor.authorWareham, Nicken
dc.contributor.authorKhaw, Kay-Teeen
dc.contributor.authorBradbury, Kathryn Een
dc.contributor.authorFreisling, Heinzen
dc.contributor.authorAune, Dagfinnen
dc.contributor.authorNorat, Teresaen
dc.contributor.authorRiboli, Elioen
dc.contributor.authorBueno-de-Mesquita, H B Asen
dc.date.accessioned2018-03-20T14:10:07Z-
dc.date.available2018-03-20T14:10:07Z-
dc.date.issued2018-03-15-
dc.identifier.citationCirculating concentrations of vitamin D in relation to pancreatic cancer risk in European populations. 2018, 142 (6):1189-1201 Int. J. Canceren
dc.identifier.issn1097-0215-
dc.identifier.pmid29114875-
dc.identifier.doi10.1002/ijc.31146-
dc.identifier.urihttp://hdl.handle.net/10029/621657-
dc.description.abstractEvidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2and 25(OH)D3combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.en
dc.language.isoenen
dc.rightsArchived with thanks to International journal of canceren
dc.titleCirculating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.en
dc.typeArticleen
dc.identifier.journalInt J Cancer 2018; 142(6):1189-1201en

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