Setting the stage for the review of the international estimate of short-term intake (IESTI) equation.

2.50
Hdl Handle:
http://hdl.handle.net/10029/621813
Title:
Setting the stage for the review of the international estimate of short-term intake (IESTI) equation.
Authors:
Richter, Anke; Sieke, Christian; Reich, Hermine; Ossendorp, Bernadette C; Breysse, Nicolas; Lutze, Jason; Mahieu, Karin; Margerison, Sam; Rietveld, Anton; Sarda, Xavier; Vial, Gaelle; van der Velde-Koerts, Trijntje
Abstract:
In the framework of setting Maximum Residue Limits (MRLs) for pesticides, both chronic and acute health risks to consumers arising from the long-term and short-term dietary exposure to pesticide residues have to be assessed. The current internationally harmonized approach for assessing the acute dietary exposure is based on deterministic methods for calculating the IESTI (International Estimate of Short-Term Intake). Recently, it became apparent that the IESTI approach needs a revision in the light of new scientific and political aspects. The main reasons that require this review were the lack of an international harmonization of the methodology which implies trade barriers as well as difficulties in risk communication concerning the public trust in regulatory systems. The most recent milestone in the scientific debate on a possible revision of the IESTI equation was an international scientific workshop held in Geneva in September 2015. The main objectives of this meeting were the re-evaluation, and where possible, the international harmonization of the input parameters for the IESTI equations as well as the equations themselves. The main recommendations from the workshop were (i) to replace the highest residue and supervised trials median residue with the maximum residue limit (MRL), (ii) to use a standard variability factor of three, (iii) to derive the P97.5 large portion value from the distribution of consumption values of dietary surveys expressed as kg food/kg bw/d, and (iv) to remove the commodity unit weight from the equations. In addition, the application of conversion factors and processing factors was addressed. On the initiative of the (World Health Organization) WHO Collaborating Centre on Chemical Food Safety at the National Institute for Public Health and the Environment (RIVM), the Netherlands, an international working group with members from the French Agency for Food, Environmental and Occupational Health and Safety, France (ANSES), Australian Pesticides and Veterinary Medicines Authority, Australia (APVMA), German Federal Institute for Risk Assessment, Germany (BfR), Chemical Regulation Division, the United Kingdom (CRD), European Food Safety Authority (EFSA), and RIVM, the Netherlands was formed after the IESTI workshop to conduct a comprehensive impact assessment of the proposed changes of the IESTI equations.
Citation:
Setting the stage for the review of the international estimate of short-term intake (IESTI) equation. 2018, 53 (6):343-351 J Environ Sci Health B
Journal:
J Environ Sci Health B 2018; 53(6):343-51
Issue Date:
3-Jun-2018
URI:
http://hdl.handle.net/10029/621813
DOI:
10.1080/03601234.2018.1439807
PubMed ID:
29584569
Type:
Article
Language:
en
ISSN:
1532-4109
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorRichter, Ankeen
dc.contributor.authorSieke, Christianen
dc.contributor.authorReich, Hermineen
dc.contributor.authorOssendorp, Bernadette Cen
dc.contributor.authorBreysse, Nicolasen
dc.contributor.authorLutze, Jasonen
dc.contributor.authorMahieu, Karinen
dc.contributor.authorMargerison, Samen
dc.contributor.authorRietveld, Antonen
dc.contributor.authorSarda, Xavieren
dc.contributor.authorVial, Gaelleen
dc.contributor.authorvan der Velde-Koerts, Trijntjeen
dc.date.accessioned2018-04-19T10:00:14Z-
dc.date.available2018-04-19T10:00:14Z-
dc.date.issued2018-06-03-
dc.identifier.citationSetting the stage for the review of the international estimate of short-term intake (IESTI) equation. 2018, 53 (6):343-351 J Environ Sci Health Ben
dc.identifier.issn1532-4109-
dc.identifier.pmid29584569-
dc.identifier.doi10.1080/03601234.2018.1439807-
dc.identifier.urihttp://hdl.handle.net/10029/621813-
dc.description.abstractIn the framework of setting Maximum Residue Limits (MRLs) for pesticides, both chronic and acute health risks to consumers arising from the long-term and short-term dietary exposure to pesticide residues have to be assessed. The current internationally harmonized approach for assessing the acute dietary exposure is based on deterministic methods for calculating the IESTI (International Estimate of Short-Term Intake). Recently, it became apparent that the IESTI approach needs a revision in the light of new scientific and political aspects. The main reasons that require this review were the lack of an international harmonization of the methodology which implies trade barriers as well as difficulties in risk communication concerning the public trust in regulatory systems. The most recent milestone in the scientific debate on a possible revision of the IESTI equation was an international scientific workshop held in Geneva in September 2015. The main objectives of this meeting were the re-evaluation, and where possible, the international harmonization of the input parameters for the IESTI equations as well as the equations themselves. The main recommendations from the workshop were (i) to replace the highest residue and supervised trials median residue with the maximum residue limit (MRL), (ii) to use a standard variability factor of three, (iii) to derive the P97.5 large portion value from the distribution of consumption values of dietary surveys expressed as kg food/kg bw/d, and (iv) to remove the commodity unit weight from the equations. In addition, the application of conversion factors and processing factors was addressed. On the initiative of the (World Health Organization) WHO Collaborating Centre on Chemical Food Safety at the National Institute for Public Health and the Environment (RIVM), the Netherlands, an international working group with members from the French Agency for Food, Environmental and Occupational Health and Safety, France (ANSES), Australian Pesticides and Veterinary Medicines Authority, Australia (APVMA), German Federal Institute for Risk Assessment, Germany (BfR), Chemical Regulation Division, the United Kingdom (CRD), European Food Safety Authority (EFSA), and RIVM, the Netherlands was formed after the IESTI workshop to conduct a comprehensive impact assessment of the proposed changes of the IESTI equations.en
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleSetting the stage for the review of the international estimate of short-term intake (IESTI) equation.en
dc.typeArticleen
dc.identifier.journalJ Environ Sci Health B 2018; 53(6):343-51en

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