Unveiling the important roles of coexisting contaminants on photochemical transformations of pharmaceuticals: Fibrate drugs as a case study.

2.50
Hdl Handle:
http://hdl.handle.net/10029/622099
Title:
Unveiling the important roles of coexisting contaminants on photochemical transformations of pharmaceuticals: Fibrate drugs as a case study.
Authors:
Zhang, Ya-Nan; Zhou, Yangjian; Qu, Jiao; Chen, Jingwen; Zhao, Jianchen; Lu, Ying; Li, Chao; Xie, Qing; Peijnenburg, Willie J G M
Abstract:
Pharmaceuticals are a group of ubiquitous emerging pollutants, many of which have been shown to undergo efficient photolysis in the environment. Photochemically produced reactive intermediates (PPRIs) sensitized by the pharmaceuticals in sunlit natural waters may induce photodegradation of coexisting compounds. In this study, the roles of coexisting contaminants on the phototransformation of pharmaceuticals were unveiled with the fibrate drugs gemfibrozil (GMF), fenofibrate (FNF), and fenofibric acid (FNFA) as model compounds. GMF undergoes initial concentration dependent photodegradation due to the involvement of singlet oxygen (1O2) initiated self-sensitized photolysis, and undergoes pH dependent photodegradation due to dissociation and hydroxyl radical (OH) generation. The decarboxylated intermediates of GMF and coexisting FNFA significantly accelerated the photodegradation of GMF. The promotional effects of the decarboxylated intermediates are attributed to generation of PPRIs, e.g. 1O2, superoxide (O2-), that subsequently react with GMF. Besides, FNFA can also promote the photodegradation of GMF through the electron transfer reaction from ground state GMF to excited state FNFA, leading to the formation of decarboxylated intermediates. The formed intermediates can subsequently also facilitate GMF photodegradation. The results presented here provided valuable novel insights into the effects of coexisting contaminants on the photodegradation of pharmaceuticals in polluted waters.
Citation:
Unveiling the important roles of coexisting contaminants on photochemical transformations of pharmaceuticals: Fibrate drugs as a case study. 2018, 358:216-221 J. Hazard. Mater.
Journal:
J Hazard Mater 2018; 358:216-21
Issue Date:
15-Sep-2018
URI:
http://hdl.handle.net/10029/622099
DOI:
10.1016/j.jhazmat.2018.06.068
PubMed ID:
29990809
Type:
Article
Language:
en
ISSN:
1873-3336
Appears in Collections:
Miscellaneous

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Ya-Nanen
dc.contributor.authorZhou, Yangjianen
dc.contributor.authorQu, Jiaoen
dc.contributor.authorChen, Jingwenen
dc.contributor.authorZhao, Jianchenen
dc.contributor.authorLu, Yingen
dc.contributor.authorLi, Chaoen
dc.contributor.authorXie, Qingen
dc.contributor.authorPeijnenburg, Willie J G Men
dc.date.accessioned2018-08-02T12:58:09Z-
dc.date.available2018-08-02T12:58:09Z-
dc.date.issued2018-09-15-
dc.identifier.citationUnveiling the important roles of coexisting contaminants on photochemical transformations of pharmaceuticals: Fibrate drugs as a case study. 2018, 358:216-221 J. Hazard. Mater.en
dc.identifier.issn1873-3336-
dc.identifier.pmid29990809-
dc.identifier.doi10.1016/j.jhazmat.2018.06.068-
dc.identifier.urihttp://hdl.handle.net/10029/622099-
dc.description.abstractPharmaceuticals are a group of ubiquitous emerging pollutants, many of which have been shown to undergo efficient photolysis in the environment. Photochemically produced reactive intermediates (PPRIs) sensitized by the pharmaceuticals in sunlit natural waters may induce photodegradation of coexisting compounds. In this study, the roles of coexisting contaminants on the phototransformation of pharmaceuticals were unveiled with the fibrate drugs gemfibrozil (GMF), fenofibrate (FNF), and fenofibric acid (FNFA) as model compounds. GMF undergoes initial concentration dependent photodegradation due to the involvement of singlet oxygen (1O2) initiated self-sensitized photolysis, and undergoes pH dependent photodegradation due to dissociation and hydroxyl radical (OH) generation. The decarboxylated intermediates of GMF and coexisting FNFA significantly accelerated the photodegradation of GMF. The promotional effects of the decarboxylated intermediates are attributed to generation of PPRIs, e.g. 1O2, superoxide (O2-), that subsequently react with GMF. Besides, FNFA can also promote the photodegradation of GMF through the electron transfer reaction from ground state GMF to excited state FNFA, leading to the formation of decarboxylated intermediates. The formed intermediates can subsequently also facilitate GMF photodegradation. The results presented here provided valuable novel insights into the effects of coexisting contaminants on the photodegradation of pharmaceuticals in polluted waters.en
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleUnveiling the important roles of coexisting contaminants on photochemical transformations of pharmaceuticals: Fibrate drugs as a case study.en
dc.typeArticleen
dc.identifier.journalJ Hazard Mater 2018; 358:216-21en

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