A category approach for reproductive effects of phthalates.

2.50
Hdl Handle:
http://hdl.handle.net/10029/6730
Title:
A category approach for reproductive effects of phthalates.
Authors:
Fabjan, Evelin; Hulzebos, Etje; Mennes, W; Piersma, Aldert H
Abstract:
In regulatory toxicology, the experimental assessment of reproductive toxicity is one of the most costly endpoints to perform. Categorizing chemicals is an approach that can be used to reduce animal tests in risk assessments of chemicals, for example, via REACH (Registration, Evaluation, and Authorization of Chemicals). The category approach was tested for reproductive toxicity with a group of 10 ortho-phthalate esters, with different side chain lengths. Three ortho-phthalates were used for testing the category. Phthalates with side-chain lengths C4 to C6 that are commonly known to cause reproductive effects were included, as well as the recently discovered mechanism that indicates antiandrogenic effects. The differences in physicochemical properties, absorption rates, and metabolism between the phthalates investigated could not fully explain the difference in reproductive toxicity. It was concluded that phthalates with the alkyl side-chain length from C4 to C6 produce similar severe reproductive effects in experimental animals. It is expected that phthalates included in the tight boundaries of the proposed category would all show severe reproductive effects, especially the antiandrogenic effects. Further testing might not be needed for phthalates within these boundaries. If necessary, limited testing could focus on the critical endpoints. Detailed mechanistic information is needed on phthalates to apply the categories for regulatory toxicology.
Citation:
Crit. Rev. Toxicol. 2006, 36(9):695-726
Issue Date:
1-Oct-2006
URI:
http://hdl.handle.net/10029/6730
DOI:
10.1080/10408440600894914
PubMed ID:
17050082
Type:
Article
Language:
en
ISSN:
1040-8444
Appears in Collections:
Substances

Full metadata record

DC FieldValue Language
dc.contributor.authorFabjan, Evelin-
dc.contributor.authorHulzebos, Etje-
dc.contributor.authorMennes, W-
dc.contributor.authorPiersma, Aldert H-
dc.date.accessioned2007-01-02T13:36:53Z-
dc.date.available2007-01-02T13:36:53Z-
dc.date.issued2006-10-01-
dc.identifier.citationCrit. Rev. Toxicol. 2006, 36(9):695-726en
dc.identifier.issn1040-8444-
dc.identifier.pmid17050082-
dc.identifier.doi10.1080/10408440600894914-
dc.identifier.urihttp://hdl.handle.net/10029/6730-
dc.description.abstractIn regulatory toxicology, the experimental assessment of reproductive toxicity is one of the most costly endpoints to perform. Categorizing chemicals is an approach that can be used to reduce animal tests in risk assessments of chemicals, for example, via REACH (Registration, Evaluation, and Authorization of Chemicals). The category approach was tested for reproductive toxicity with a group of 10 ortho-phthalate esters, with different side chain lengths. Three ortho-phthalates were used for testing the category. Phthalates with side-chain lengths C4 to C6 that are commonly known to cause reproductive effects were included, as well as the recently discovered mechanism that indicates antiandrogenic effects. The differences in physicochemical properties, absorption rates, and metabolism between the phthalates investigated could not fully explain the difference in reproductive toxicity. It was concluded that phthalates with the alkyl side-chain length from C4 to C6 produce similar severe reproductive effects in experimental animals. It is expected that phthalates included in the tight boundaries of the proposed category would all show severe reproductive effects, especially the antiandrogenic effects. Further testing might not be needed for phthalates within these boundaries. If necessary, limited testing could focus on the critical endpoints. Detailed mechanistic information is needed on phthalates to apply the categories for regulatory toxicology.en
dc.format.extent387951 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleA category approach for reproductive effects of phthalates.en
dc.typeArticleen
dc.format.digYES-

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