Using data on social contacts to estimate age-specific transmission parameters for respiratory-spread infectious agents.

2.50
Hdl Handle:
http://hdl.handle.net/10029/6739
Title:
Using data on social contacts to estimate age-specific transmission parameters for respiratory-spread infectious agents.
Authors:
Wallinga, Jacco; Teunis, Peter F M; Kretzschmar, Mirjam
Abstract:
The estimation of transmission parameters has been problematic for diseases that rely predominantly on transmission of pathogens from person to person through small infectious droplets. Age-specific transmission parameters determine how such respiratory agents will spread among different age groups in a human population. Estimating the values of these parameters is essential in planning an effective response to potentially devastating pandemics of smallpox or influenza and in designing control strategies for diseases such as measles or mumps. In this study, the authors estimated age-specific transmission parameters by augmenting infectious disease data with auxiliary data on self-reported numbers of conversational partners per person. They show that models that use transmission parameters based on these self-reported social contacts are better able to capture the observed patterns of infection of endemically circulating mumps, as well as observed patterns of spread of pandemic influenza. The estimated age-specific transmission parameters suggested that school-aged children and young adults will experience the highest incidence of infection and will contribute most to further spread of infections during the initial phase of an emerging respiratory-spread epidemic in a completely susceptible population. These findings have important implications for controlling future outbreaks of novel respiratory-spread infectious agents.
Citation:
Am. J. Epidemiol. 2006, 164(10):936-44
Issue Date:
15-Nov-2006
URI:
http://hdl.handle.net/10029/6739
DOI:
10.1093/aje/kwj317
PubMed ID:
16968863
Type:
Article
Language:
en
ISSN:
0002-9262
Appears in Collections:
Infectious Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorWallinga, Jacco-
dc.contributor.authorTeunis, Peter F M-
dc.contributor.authorKretzschmar, Mirjam-
dc.date.accessioned2007-01-02T14:58:33Z-
dc.date.available2007-01-02T14:58:33Z-
dc.date.issued2006-11-15-
dc.identifier.citationAm. J. Epidemiol. 2006, 164(10):936-44en
dc.identifier.issn0002-9262-
dc.identifier.pmid16968863-
dc.identifier.doi10.1093/aje/kwj317-
dc.identifier.urihttp://hdl.handle.net/10029/6739-
dc.description.abstractThe estimation of transmission parameters has been problematic for diseases that rely predominantly on transmission of pathogens from person to person through small infectious droplets. Age-specific transmission parameters determine how such respiratory agents will spread among different age groups in a human population. Estimating the values of these parameters is essential in planning an effective response to potentially devastating pandemics of smallpox or influenza and in designing control strategies for diseases such as measles or mumps. In this study, the authors estimated age-specific transmission parameters by augmenting infectious disease data with auxiliary data on self-reported numbers of conversational partners per person. They show that models that use transmission parameters based on these self-reported social contacts are better able to capture the observed patterns of infection of endemically circulating mumps, as well as observed patterns of spread of pandemic influenza. The estimated age-specific transmission parameters suggested that school-aged children and young adults will experience the highest incidence of infection and will contribute most to further spread of infections during the initial phase of an emerging respiratory-spread epidemic in a completely susceptible population. These findings have important implications for controlling future outbreaks of novel respiratory-spread infectious agents.en
dc.format.extent259375 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleUsing data on social contacts to estimate age-specific transmission parameters for respiratory-spread infectious agents.en
dc.typeArticleen
dc.format.digYES-

Related articles on PubMed

All Items in WARP are protected by copyright, with all rights reserved, unless otherwise indicated.