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Webbased Archive of RIVM Publications > Articles and other publications by RIVM employees > Vaccines and Vaccination > Preclinical and clinical safety studies on DNA vaccines.

Please use this identifier to cite or link to this item: http://hdl.handle.net/10029/6776
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Title: Preclinical and clinical safety studies on DNA vaccines.
Authors: Schalk, Johanna A C
Mooi, Frits R
Berbers, Guy A M
Aerts, Leon A G J M van
Ovelgönne, Hans
Kimman, Tjeerd G
Citation: Hum Vaccin null, 2(2):45-53
Issue Date: 3-Jan-2007
URI: http://hdl.handle.net/10029/6776
PubMed ID: 17012886
Abstract: DNA vaccines are based on the transfer of genetic material, encoding an antigen, to the cells of the vaccine recipient. Despite high expectations of DNA vaccines as a result of promising preclinical data their clinical utility remains unproven. However, much data is gathered in preclinical and clinical studies about the safety of DNA vaccines. Here we review current knowledge about the safety of DNA vaccines. Safety concerns of DNA vaccines relate to genetic, immunologic, toxic, and environmental effects. In this review we provide an overview of findings related to the safety of DNA vaccines, obtained so far. We conclude that the potential risks of DNA vaccines are minimal. However, their safety issues may differ case-by-case, and they should be treated accordingly.
Type: Article
Language: en
ISSN: 1554-8600
Appears in Collections:  Vaccines and Vaccination

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