Intakes of 4 dietary lignans and cause-specific and all-cause mortality in the Zutphen Elderly Study.

2.50
Hdl Handle:
http://hdl.handle.net/10029/6785
Title:
Intakes of 4 dietary lignans and cause-specific and all-cause mortality in the Zutphen Elderly Study.
Authors:
Milder, Ivon E J; Feskens, Edith J M; Arts, Ilja C W; Bueno-de-Mesquita, H Bas; Hollman, Peter C H; Kromhout, Daan
Abstract:
BACKGROUND: Plant lignans are converted to enterolignans that have antioxidant and weak estrogen-like activities, and therefore they may lower cardiovascular disease and cancer risks. OBJECTIVE: We investigated whether the intakes of 4 plant lignans (lariciresinol, pinoresinol, secoisolariciresinol, and matairesinol) were inversely associated with coronary heart disease (CHD), cardiovascular diseases (CVD), cancer, and all-cause mortality. DESIGN: The Zutphen Elderly Study is a prospective cohort study in which 570 men aged 64-84 y were followed for 15 y. We recently developed a database and used it to estimate the dietary intakes of 4 plant lignans. Lignan intake was related to mortality with the use of Cox proportional hazards analysis. RESULTS: The median total lignan intake in 1985 was 977 microg/d. Tea, vegetables, bread, coffee, fruit, and wine were the major sources of lignan. The total lignan intake was not related to mortality. However, the intake of matairesinol was inversely associated with CHD, CVD, and all-cause mortality (P </= 0.05 for all) and cancer (P = 0.06). Multivariate-adjusted rate ratios (95% CI) per 1-SD increase in intake were 0.72 (0.53, 0.98) for CHD, 0.83 (0.69, 1.00) for CVD, 0.86 (0.76, 0.97) for all-cause mortality, and 0.81 (0.65, 1.00) for cancer. CONCLUSIONS: Total lignan intake was not associated with mortality. The intake of matairesinol was inversely associated with mortality due to CHD, CVD, cancer, and all causes. We cannot exclude the possibility that the inverse association between matairesinol intake and mortality is due to an associated factor, such as wine consumption.
Citation:
Am. J. Clin. Nutr. 2006, 84(2):400-5
Issue Date:
1-Aug-2006
URI:
http://hdl.handle.net/10029/6785
PubMed ID:
16895890
Type:
Article
Language:
en
ISSN:
0002-9165
Appears in Collections:
Public Health and Health Care

Full metadata record

DC FieldValue Language
dc.contributor.authorMilder, Ivon E J-
dc.contributor.authorFeskens, Edith J M-
dc.contributor.authorArts, Ilja C W-
dc.contributor.authorBueno-de-Mesquita, H Bas-
dc.contributor.authorHollman, Peter C H-
dc.contributor.authorKromhout, Daan-
dc.date.accessioned2007-01-03T14:42:38Z-
dc.date.available2007-01-03T14:42:38Z-
dc.date.issued2006-08-01-
dc.identifier.citationAm. J. Clin. Nutr. 2006, 84(2):400-5en
dc.identifier.issn0002-9165-
dc.identifier.pmid16895890-
dc.identifier.urihttp://hdl.handle.net/10029/6785-
dc.description.abstractBACKGROUND: Plant lignans are converted to enterolignans that have antioxidant and weak estrogen-like activities, and therefore they may lower cardiovascular disease and cancer risks. OBJECTIVE: We investigated whether the intakes of 4 plant lignans (lariciresinol, pinoresinol, secoisolariciresinol, and matairesinol) were inversely associated with coronary heart disease (CHD), cardiovascular diseases (CVD), cancer, and all-cause mortality. DESIGN: The Zutphen Elderly Study is a prospective cohort study in which 570 men aged 64-84 y were followed for 15 y. We recently developed a database and used it to estimate the dietary intakes of 4 plant lignans. Lignan intake was related to mortality with the use of Cox proportional hazards analysis. RESULTS: The median total lignan intake in 1985 was 977 microg/d. Tea, vegetables, bread, coffee, fruit, and wine were the major sources of lignan. The total lignan intake was not related to mortality. However, the intake of matairesinol was inversely associated with CHD, CVD, and all-cause mortality (P </= 0.05 for all) and cancer (P = 0.06). Multivariate-adjusted rate ratios (95% CI) per 1-SD increase in intake were 0.72 (0.53, 0.98) for CHD, 0.83 (0.69, 1.00) for CVD, 0.86 (0.76, 0.97) for all-cause mortality, and 0.81 (0.65, 1.00) for cancer. CONCLUSIONS: Total lignan intake was not associated with mortality. The intake of matairesinol was inversely associated with mortality due to CHD, CVD, cancer, and all causes. We cannot exclude the possibility that the inverse association between matairesinol intake and mortality is due to an associated factor, such as wine consumption.en
dc.format.extent134598 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleIntakes of 4 dietary lignans and cause-specific and all-cause mortality in the Zutphen Elderly Study.en
dc.typeArticleen
dc.format.digYES-

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