Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.

2.50
Hdl Handle:
http://hdl.handle.net/10029/6828
Title:
Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.
Authors:
Jakszyn, Paula; Bingham, Sheila A; Pera, Guillem; Agudo, Antonio; Luben, Robert; Welch, Ailsa; Boeing, Heiner; Giudice, Giuseppe del; Palli, Domenico; Saieva, Calogero; Krogh, Vittorio; Sacerdote, Carlotta; Tumino, Rosario; Panico, Salvatore; Berglund, Göran; Simán, Henrik; Hallmans, Göran; Sanchez, María José; Larrañaga, Nerea; Barricarte, Aurelio; Chirlaque, María-Dolores; Quirós, José Ramón; Key, Timothy J; Allen, Naomi E; Lund, Eiliv; Carneiro, Fátima; Linseisen, Jakob; Nagel, Gabriele; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Bueno-de-Mesquita, H Bas; Ocké, Marga C; Peeters, Petra H M; Numans, Mattijs E; Clavel-Chapelon, Françoise; Trichopoulou, Antonia; Fenger, Claus; Stenling, Roger; Ferrari, Pietro; Jenab, Mazda; Norat, Teresa; Riboli, Elio; González, Carlos Alberto
Abstract:
The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was < 1 microg on average compared with 93 mug on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 microg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.
Citation:
Carcinogenesis 2006, 27(7):1497-501
Issue Date:
1-Jul-2006
URI:
http://hdl.handle.net/10029/6828
DOI:
10.1093/carcin/bgl019
PubMed ID:
16571648
Type:
Article
Language:
en
ISSN:
0143-3334
Appears in Collections:
Nutrition and Drinking Water

Full metadata record

DC FieldValue Language
dc.contributor.authorJakszyn, Paula-
dc.contributor.authorBingham, Sheila A-
dc.contributor.authorPera, Guillem-
dc.contributor.authorAgudo, Antonio-
dc.contributor.authorLuben, Robert-
dc.contributor.authorWelch, Ailsa-
dc.contributor.authorBoeing, Heiner-
dc.contributor.authorGiudice, Giuseppe del-
dc.contributor.authorPalli, Domenico-
dc.contributor.authorSaieva, Calogero-
dc.contributor.authorKrogh, Vittorio-
dc.contributor.authorSacerdote, Carlotta-
dc.contributor.authorTumino, Rosario-
dc.contributor.authorPanico, Salvatore-
dc.contributor.authorBerglund, Göran-
dc.contributor.authorSimán, Henrik-
dc.contributor.authorHallmans, Göran-
dc.contributor.authorSanchez, María José-
dc.contributor.authorLarrañaga, Nerea-
dc.contributor.authorBarricarte, Aurelio-
dc.contributor.authorChirlaque, María-Dolores-
dc.contributor.authorQuirós, José Ramón-
dc.contributor.authorKey, Timothy J-
dc.contributor.authorAllen, Naomi E-
dc.contributor.authorLund, Eiliv-
dc.contributor.authorCarneiro, Fátima-
dc.contributor.authorLinseisen, Jakob-
dc.contributor.authorNagel, Gabriele-
dc.contributor.authorOvervad, Kim-
dc.contributor.authorTjønneland, Anne-
dc.contributor.authorOlsen, Anja-
dc.contributor.authorBueno-de-Mesquita, H Bas-
dc.contributor.authorOcké, Marga C-
dc.contributor.authorPeeters, Petra H M-
dc.contributor.authorNumans, Mattijs E-
dc.contributor.authorClavel-Chapelon, Françoise-
dc.contributor.authorTrichopoulou, Antonia-
dc.contributor.authorFenger, Claus-
dc.contributor.authorStenling, Roger-
dc.contributor.authorFerrari, Pietro-
dc.contributor.authorJenab, Mazda-
dc.contributor.authorNorat, Teresa-
dc.contributor.authorRiboli, Elio-
dc.contributor.authorGonzález, Carlos Alberto-
dc.date.accessioned2007-01-04T09:34:43Z-
dc.date.available2007-01-04T09:34:43Z-
dc.date.issued2006-07-01-
dc.identifier.citationCarcinogenesis 2006, 27(7):1497-501en
dc.identifier.issn0143-3334-
dc.identifier.pmid16571648-
dc.identifier.doi10.1093/carcin/bgl019-
dc.identifier.urihttp://hdl.handle.net/10029/6828-
dc.description.abstractThe risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was < 1 microg on average compared with 93 mug on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 microg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.en
dc.format.extent114539 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleEndogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.en
dc.typeArticleen
dc.format.digYES-

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