Epidemic spread of recombinant noroviruses with four capsid types in Hungary.

2.50
Hdl Handle:
http://hdl.handle.net/10029/6922
Title:
Epidemic spread of recombinant noroviruses with four capsid types in Hungary.
Authors:
Reuter, Gábor; Vennema, Harry; Koopmans, Marion P G; Szücs, György
Abstract:
BACKGROUND: Noroviruses are common pathogens in gastro-enteritis outbreaks in humans worldwide. Noroviruses are genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These viruses had a distinct polymerase gene sequence (designated GGIIb/Hilversum) and were disseminated through waterborne and food-borne transmission in Europe. OBJECTIVES: Our aim was to characterize these emerging recombinant noroviruses causing outbreaks of gastro-enteritis in Hungary. STUDY DESIGN: From January 2001 to May 2004, samples containing "GGIIb/Hilversum polymerase" (GGIIb-pol) were selected for analysis of the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing. RESULTS: Thirty-four (14.4%) of 236 confirmed norovirus outbreaks were caused by the variant lineage with the GGIIb-pol. Four different recombinants were detected with capsids of Hu/NLV/GGII/Mexico/1989 (n=9, 43%), Hu/NLV/GGII/Snow Mountain/1976 (n=6, 28%), Hu/NLV/GGII/Hawaii/1971 (n=4, 19%) and Hu/NLV/GGII/Lordsdale/1993 (n=1, 5%). CONCLUSIONS: In Hungary, emerging recombinant noroviruses became the second most common norovirus variants-next to GGII-4/Lordsdale virus-causing epidemics of gastroenteritis in the last 4 years.
Citation:
J. Clin. Virol. 2006, 35(1):84-8
Issue Date:
1-Jan-2006
URI:
http://hdl.handle.net/10029/6922
DOI:
10.1016/j.jcv.2005.07.012
PubMed ID:
16242995
Type:
Article
Language:
en
ISSN:
1386-6532
Appears in Collections:
Infectious Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorReuter, Gábor-
dc.contributor.authorVennema, Harry-
dc.contributor.authorKoopmans, Marion P G-
dc.contributor.authorSzücs, György-
dc.date.accessioned2007-01-05T09:39:27Z-
dc.date.available2007-01-05T09:39:27Z-
dc.date.issued2006-01-01-
dc.identifier.citationJ. Clin. Virol. 2006, 35(1):84-8en
dc.identifier.issn1386-6532-
dc.identifier.pmid16242995-
dc.identifier.doi10.1016/j.jcv.2005.07.012-
dc.identifier.urihttp://hdl.handle.net/10029/6922-
dc.description.abstractBACKGROUND: Noroviruses are common pathogens in gastro-enteritis outbreaks in humans worldwide. Noroviruses are genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These viruses had a distinct polymerase gene sequence (designated GGIIb/Hilversum) and were disseminated through waterborne and food-borne transmission in Europe. OBJECTIVES: Our aim was to characterize these emerging recombinant noroviruses causing outbreaks of gastro-enteritis in Hungary. STUDY DESIGN: From January 2001 to May 2004, samples containing "GGIIb/Hilversum polymerase" (GGIIb-pol) were selected for analysis of the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) and sequencing. RESULTS: Thirty-four (14.4%) of 236 confirmed norovirus outbreaks were caused by the variant lineage with the GGIIb-pol. Four different recombinants were detected with capsids of Hu/NLV/GGII/Mexico/1989 (n=9, 43%), Hu/NLV/GGII/Snow Mountain/1976 (n=6, 28%), Hu/NLV/GGII/Hawaii/1971 (n=4, 19%) and Hu/NLV/GGII/Lordsdale/1993 (n=1, 5%). CONCLUSIONS: In Hungary, emerging recombinant noroviruses became the second most common norovirus variants-next to GGII-4/Lordsdale virus-causing epidemics of gastroenteritis in the last 4 years.en
dc.format.extent212589 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleEpidemic spread of recombinant noroviruses with four capsid types in Hungary.en
dc.typeArticleen
dc.format.digYES-

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