Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC).

2.50
Hdl Handle:
http://hdl.handle.net/10029/6924
Title:
Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Authors:
Pischon, Tobias; Lahmann, Petra H; Boeing, Heiner; Tjønneland, Anne; Halkjaer, Jytte; Overvad, Kim; Klipstein-Grobusch, Kerstin; Linseisen, Jakob; Becker, Nikolaus; Trichopoulou, Antonia; Benetou, Vassiliki; Trichopoulos, Dimitrios; Sieri, Sabina; Palli, Domenico; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Monninkhof, Evelyn; Peeters, Petra H M; Bueno-de-Mesquita, H Bas; Büchner, Frederike L; Ljungberg, Börje; Hallmans, Göran; Berglund, Göran; González, Carlos Alberto; Dorronsoro Iraeta, Miren; Gurrea, Aurelio Barricarte; Navarro, Carmen A; Martínez-García, Carmen; Quirós, José Ramón; Roddam, Andrew; Allen, Naomi E; Bingham, Sheila A; Khaw, Kay-Tee; Kaaks, Rudolf; Norat, Teresa; Slimani, Nadia; Riboli, Elio
Abstract:
Previous studies suggest that obesity is related to increased risk of renal cell carcinoma (RCC); however, only a few studies report on measures of central vs. peripheral adiposity. We examined the association between anthropometric measures, including waist and hip circumference and RCC risk among 348,550 men and women free of cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 6.0 years of follow-up we identified 287 incident cases of RCC. Relative risks were calculated using Cox regression, stratified by age and study center and adjusted for smoking status, education, alcohol consumption, physical activity, menopausal status, and hormone replacement therapy use. Among women, an increased risk of RCC was conferred by body weight (relative risk [RR] in highest vs. lowest quintile = 2.13; 95% confidence interval [CI] = 1.16-3.90; p-trend = 0.003), body mass index (BMI) (RR = 2.25; 95% CI = 1.14-4.44; p-trend = 0.009), and waist (RR = 1.67; 95% CI = 0.94-2.98; p-trend = 0.003) and hip circumference (RR = 2.30; 95% CI = 1.22-4.34; p-trend = 0.01); however, waist and hip circumference were no longer significant after controlling for body weight. Among men, hip circumference (RR = 0.44; 95% CI = 0.20-0.98; p-trend = 0.03) was related significantly to decreased RCC risk only after accounting for body weight. Height was not related significantly to RCC risk. Our findings suggest that obesity is related to increased risk of RCC irrespective of fat distribution among women, whereas low hip circumference is related to increased RCC risk among men. Our data give further credence to public health efforts aiming to reduce the prevalence of obesity to prevent RCC, in addition to other chronic diseases.
Citation:
Int. J. Cancer 2006, 118(3):728-38
Issue Date:
1-Feb-2006
URI:
http://hdl.handle.net/10029/6924
DOI:
10.1002/ijc.21398
PubMed ID:
16094628
Type:
Article
Language:
en
ISSN:
0020-7136
Appears in Collections:
Public Health and Health Care

Full metadata record

DC FieldValue Language
dc.contributor.authorPischon, Tobias-
dc.contributor.authorLahmann, Petra H-
dc.contributor.authorBoeing, Heiner-
dc.contributor.authorTjønneland, Anne-
dc.contributor.authorHalkjaer, Jytte-
dc.contributor.authorOvervad, Kim-
dc.contributor.authorKlipstein-Grobusch, Kerstin-
dc.contributor.authorLinseisen, Jakob-
dc.contributor.authorBecker, Nikolaus-
dc.contributor.authorTrichopoulou, Antonia-
dc.contributor.authorBenetou, Vassiliki-
dc.contributor.authorTrichopoulos, Dimitrios-
dc.contributor.authorSieri, Sabina-
dc.contributor.authorPalli, Domenico-
dc.contributor.authorTumino, Rosario-
dc.contributor.authorVineis, Paolo-
dc.contributor.authorPanico, Salvatore-
dc.contributor.authorMonninkhof, Evelyn-
dc.contributor.authorPeeters, Petra H M-
dc.contributor.authorBueno-de-Mesquita, H Bas-
dc.contributor.authorBüchner, Frederike L-
dc.contributor.authorLjungberg, Börje-
dc.contributor.authorHallmans, Göran-
dc.contributor.authorBerglund, Göran-
dc.contributor.authorGonzález, Carlos Alberto-
dc.contributor.authorDorronsoro Iraeta, Miren-
dc.contributor.authorGurrea, Aurelio Barricarte-
dc.contributor.authorNavarro, Carmen A-
dc.contributor.authorMartínez-García, Carmen-
dc.contributor.authorQuirós, José Ramón-
dc.contributor.authorRoddam, Andrew-
dc.contributor.authorAllen, Naomi E-
dc.contributor.authorBingham, Sheila A-
dc.contributor.authorKhaw, Kay-Tee-
dc.contributor.authorKaaks, Rudolf-
dc.contributor.authorNorat, Teresa-
dc.contributor.authorSlimani, Nadia-
dc.contributor.authorRiboli, Elio-
dc.date.accessioned2007-01-05T10:25:20Z-
dc.date.available2007-01-05T10:25:20Z-
dc.date.issued2006-02-01-
dc.identifier.citationInt. J. Cancer 2006, 118(3):728-38en
dc.identifier.issn0020-7136-
dc.identifier.pmid16094628-
dc.identifier.doi10.1002/ijc.21398-
dc.identifier.urihttp://hdl.handle.net/10029/6924-
dc.description.abstractPrevious studies suggest that obesity is related to increased risk of renal cell carcinoma (RCC); however, only a few studies report on measures of central vs. peripheral adiposity. We examined the association between anthropometric measures, including waist and hip circumference and RCC risk among 348,550 men and women free of cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 6.0 years of follow-up we identified 287 incident cases of RCC. Relative risks were calculated using Cox regression, stratified by age and study center and adjusted for smoking status, education, alcohol consumption, physical activity, menopausal status, and hormone replacement therapy use. Among women, an increased risk of RCC was conferred by body weight (relative risk [RR] in highest vs. lowest quintile = 2.13; 95% confidence interval [CI] = 1.16-3.90; p-trend = 0.003), body mass index (BMI) (RR = 2.25; 95% CI = 1.14-4.44; p-trend = 0.009), and waist (RR = 1.67; 95% CI = 0.94-2.98; p-trend = 0.003) and hip circumference (RR = 2.30; 95% CI = 1.22-4.34; p-trend = 0.01); however, waist and hip circumference were no longer significant after controlling for body weight. Among men, hip circumference (RR = 0.44; 95% CI = 0.20-0.98; p-trend = 0.03) was related significantly to decreased RCC risk only after accounting for body weight. Height was not related significantly to RCC risk. Our findings suggest that obesity is related to increased risk of RCC irrespective of fat distribution among women, whereas low hip circumference is related to increased RCC risk among men. Our data give further credence to public health efforts aiming to reduce the prevalence of obesity to prevent RCC, in addition to other chronic diseases.en
dc.format.extent209952 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleBody size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC).en
dc.typeArticleen
dc.format.digYES-

Related articles on PubMed

All Items in WARP are protected by copyright, with all rights reserved, unless otherwise indicated.