Significance of ammonium compounds on nicotine exposure to cigarette smokers.

2.50
Hdl Handle:
http://hdl.handle.net/10029/7087
Title:
Significance of ammonium compounds on nicotine exposure to cigarette smokers.
Authors:
Willems, E W; Rambali, B; Vleeming, W; Opperhuizen, Antoon; Amsterdam, J G C van
Abstract:
The tobacco industry publicly contends that ammonia compounds are solely used as tobacco additive for purposes of tobacco flavoring, process conditioning and reduction of its subjective harshness and irritation. However, neither objective scientific reports, nor the contents of a large number of internal tobacco company documents support this contention. The present review focuses on the hypothesis that addition of ammonium compounds to tobacco enhances global tobacco use due to smoke alkalization and enhanced free-nicotine nicotine exposure. Obviously, ammonia enhances the alkalinity of tobacco smoke. Consequently, the equilibrium shifts from non-volatile nicotine salts to the volatile free base that is more readily absorbed from the airways. The observed change in the kinetics of nicotine (i.e., shorter t(1/2) and higher c(max)) after ammoniation is, however, predominantly due to the higher concentration of nicotine in the smoke, rather than to an increase in the absorption rate of free-base nicotine in the respiratory tract. Although several findings support the hypothesis, additional studies are required and suggested to provide a proper, objective and independent scientific judgment about the effect of tobacco ammoniation on nicotine bioavailability. Scientific and public awareness of the effects of tobacco-specific ammonia compounds may stimulate global control, legislation and restriction of their use in cigarette manufacture.
Citation:
Food Chem. Toxicol. 2006, 44(5):678-88
Issue Date:
1-May-2006
URI:
http://hdl.handle.net/10029/7087
DOI:
10.1016/j.fct.2005.09.007
PubMed ID:
16288944
Type:
Article
Language:
en
ISSN:
0278-6915
Appears in Collections:
Substances

Full metadata record

DC FieldValue Language
dc.contributor.authorWillems, E W-
dc.contributor.authorRambali, B-
dc.contributor.authorVleeming, W-
dc.contributor.authorOpperhuizen, Antoon-
dc.contributor.authorAmsterdam, J G C van-
dc.date.accessioned2007-01-09T14:35:38Z-
dc.date.available2007-01-09T14:35:38Z-
dc.date.issued2006-05-01-
dc.identifier.citationFood Chem. Toxicol. 2006, 44(5):678-88en
dc.identifier.issn0278-6915-
dc.identifier.pmid16288944-
dc.identifier.doi10.1016/j.fct.2005.09.007-
dc.identifier.urihttp://hdl.handle.net/10029/7087-
dc.description.abstractThe tobacco industry publicly contends that ammonia compounds are solely used as tobacco additive for purposes of tobacco flavoring, process conditioning and reduction of its subjective harshness and irritation. However, neither objective scientific reports, nor the contents of a large number of internal tobacco company documents support this contention. The present review focuses on the hypothesis that addition of ammonium compounds to tobacco enhances global tobacco use due to smoke alkalization and enhanced free-nicotine nicotine exposure. Obviously, ammonia enhances the alkalinity of tobacco smoke. Consequently, the equilibrium shifts from non-volatile nicotine salts to the volatile free base that is more readily absorbed from the airways. The observed change in the kinetics of nicotine (i.e., shorter t(1/2) and higher c(max)) after ammoniation is, however, predominantly due to the higher concentration of nicotine in the smoke, rather than to an increase in the absorption rate of free-base nicotine in the respiratory tract. Although several findings support the hypothesis, additional studies are required and suggested to provide a proper, objective and independent scientific judgment about the effect of tobacco ammoniation on nicotine bioavailability. Scientific and public awareness of the effects of tobacco-specific ammonia compounds may stimulate global control, legislation and restriction of their use in cigarette manufacture.en
dc.format.extent315135 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleSignificance of ammonium compounds on nicotine exposure to cigarette smokers.en
dc.typeArticleen
dc.format.digYES-

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