2.50
Hdl Handle:
http://hdl.handle.net/10029/7088
Title:
Migraine and MTHFR C677T genotype in a population-based sample.
Authors:
Scher, Ann I; Terwindt, Gisela M; Verschuren, W M Monique; Kruit, Mark C; Blom, Henk J; Kowa, Hisanori; Frants, Rune R; Maagdenberg, Arn M J M van den; Buchem, Mark A van; Ferrari, Michel D; Launer, Lenore J
Abstract:
OBJECTIVE: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. METHODS: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. RESULTS: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. INTERPRETATION: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.
Citation:
Ann. Neurol. 2006, 59(2):372-5
Issue Date:
1-Feb-2006
URI:
http://hdl.handle.net/10029/7088
DOI:
10.1002/ana.20755
PubMed ID:
16365871
Type:
Article
Language:
en
ISSN:
0364-5134
Appears in Collections:
Public Health and Health Care

Full metadata record

DC FieldValue Language
dc.contributor.authorScher, Ann I-
dc.contributor.authorTerwindt, Gisela M-
dc.contributor.authorVerschuren, W M Monique-
dc.contributor.authorKruit, Mark C-
dc.contributor.authorBlom, Henk J-
dc.contributor.authorKowa, Hisanori-
dc.contributor.authorFrants, Rune R-
dc.contributor.authorMaagdenberg, Arn M J M van den-
dc.contributor.authorBuchem, Mark A van-
dc.contributor.authorFerrari, Michel D-
dc.contributor.authorLauner, Lenore J-
dc.date.accessioned2007-01-09T14:36:47Z-
dc.date.available2007-01-09T14:36:47Z-
dc.date.issued2006-02-01-
dc.identifier.citationAnn. Neurol. 2006, 59(2):372-5en
dc.identifier.issn0364-5134-
dc.identifier.pmid16365871-
dc.identifier.doi10.1002/ana.20755-
dc.identifier.urihttp://hdl.handle.net/10029/7088-
dc.description.abstractOBJECTIVE: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. METHODS: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. RESULTS: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. INTERPRETATION: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.en
dc.format.extent80893 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleMigraine and MTHFR C677T genotype in a population-based sample.en
dc.typeArticleen
dc.format.digYES-

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