Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.

2.50
Hdl Handle:
http://hdl.handle.net/10029/7096
Title:
Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.
Authors:
Canzian, F; McKay, J D; Cleveland, R J; Dossus, Laure; Biessy, Carine; Rinaldi, Sabina; Landi, S; Boillot, C; Monnier, S; Chajès, V; Clavel-Chapelon, Françoise; Téhard, B; Chang-Claude, J; Linseisen, Jakob; Lahmann, Petra H; Pischon, Tobias; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Zilis, D; Palli, Domenico; Tumino, Rosario; Vineis, Paolo; Berrino, Franco; Bueno-de-Mesquita, H Bas; Gils, C H van; Peeters, Petra H M; Pera, Guillem; Ardanaz, Eva; Chirlaque, María-Dolores; Quirós, José Ramón; Larrañaga, Nerea; Martínez-García, Carmen; Allen, Naomi E; Key, Timothy J; Bingham, Sheila A; Khaw, Kay-Tee; Slimani, N; Norat, Teresa; Riboli, Elio; Kaaks, Rudolf
Abstract:
Insulin-like growth factor I (IGF-I) stimulates cell proliferation and can enhance the development of tumours in different organs. Epidemiological studies have shown that an elevated level of circulating IGF-I is associated with increased risk of breast cancer, as well as of other cancers. Most of circulating IGF-I is bound to an acid-labile subunit and to one of six insulin-like growth factor binding proteins (IGFBPs), among which the most important are IGFBP-3 and IGFBP-1. Polymorphisms of the IGF1 gene and of genes encoding for the major IGF-I carriers may predict circulating levels of IGF-I and have an impact on cancer risk. We tested this hypothesis with a case-control study of 807 breast cancer patients and 1588 matched control subjects, nested within the European Prospective Investigation into Cancer and Nutrition. We genotyped 23 common single nucleotide polymorphisms in IGF1, IGFBP1, IGFBP3 and IGFALS, and measured serum levels of IGF-I and IGFBP-3 in samples of cases and controls. We found a weak but significant association of polymorphisms at the 5' end of the IGF1 gene with breast cancer risk, particularly among women younger than 55 years, and a strong association of polymorphisms located in the 5' end of IGFBP3 with circulating levels of IGFBP-3, which confirms previous findings. Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians.
Citation:
Br. J. Cancer 2006, 94(2):299-307
Issue Date:
30-Jan-2006
URI:
http://hdl.handle.net/10029/7096
DOI:
10.1038/sj.bjc.6602936
PubMed ID:
16404426
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
Public Health and Health Care

Full metadata record

DC FieldValue Language
dc.contributor.authorCanzian, F-
dc.contributor.authorMcKay, J D-
dc.contributor.authorCleveland, R J-
dc.contributor.authorDossus, Laure-
dc.contributor.authorBiessy, Carine-
dc.contributor.authorRinaldi, Sabina-
dc.contributor.authorLandi, S-
dc.contributor.authorBoillot, C-
dc.contributor.authorMonnier, S-
dc.contributor.authorChajès, V-
dc.contributor.authorClavel-Chapelon, Françoise-
dc.contributor.authorTéhard, B-
dc.contributor.authorChang-Claude, J-
dc.contributor.authorLinseisen, Jakob-
dc.contributor.authorLahmann, Petra H-
dc.contributor.authorPischon, Tobias-
dc.contributor.authorTrichopoulos, Dimitrios-
dc.contributor.authorTrichopoulou, Antonia-
dc.contributor.authorZilis, D-
dc.contributor.authorPalli, Domenico-
dc.contributor.authorTumino, Rosario-
dc.contributor.authorVineis, Paolo-
dc.contributor.authorBerrino, Franco-
dc.contributor.authorBueno-de-Mesquita, H Bas-
dc.contributor.authorGils, C H van-
dc.contributor.authorPeeters, Petra H M-
dc.contributor.authorPera, Guillem-
dc.contributor.authorArdanaz, Eva-
dc.contributor.authorChirlaque, María-Dolores-
dc.contributor.authorQuirós, José Ramón-
dc.contributor.authorLarrañaga, Nerea-
dc.contributor.authorMartínez-García, Carmen-
dc.contributor.authorAllen, Naomi E-
dc.contributor.authorKey, Timothy J-
dc.contributor.authorBingham, Sheila A-
dc.contributor.authorKhaw, Kay-Tee-
dc.contributor.authorSlimani, N-
dc.contributor.authorNorat, Teresa-
dc.contributor.authorRiboli, Elio-
dc.contributor.authorKaaks, Rudolf-
dc.date.accessioned2007-01-09T15:24:58Z-
dc.date.available2007-01-09T15:24:58Z-
dc.date.issued2006-01-30-
dc.identifier.citationBr. J. Cancer 2006, 94(2):299-307en
dc.identifier.issn0007-0920-
dc.identifier.pmid16404426-
dc.identifier.doi10.1038/sj.bjc.6602936-
dc.identifier.urihttp://hdl.handle.net/10029/7096-
dc.description.abstractInsulin-like growth factor I (IGF-I) stimulates cell proliferation and can enhance the development of tumours in different organs. Epidemiological studies have shown that an elevated level of circulating IGF-I is associated with increased risk of breast cancer, as well as of other cancers. Most of circulating IGF-I is bound to an acid-labile subunit and to one of six insulin-like growth factor binding proteins (IGFBPs), among which the most important are IGFBP-3 and IGFBP-1. Polymorphisms of the IGF1 gene and of genes encoding for the major IGF-I carriers may predict circulating levels of IGF-I and have an impact on cancer risk. We tested this hypothesis with a case-control study of 807 breast cancer patients and 1588 matched control subjects, nested within the European Prospective Investigation into Cancer and Nutrition. We genotyped 23 common single nucleotide polymorphisms in IGF1, IGFBP1, IGFBP3 and IGFALS, and measured serum levels of IGF-I and IGFBP-3 in samples of cases and controls. We found a weak but significant association of polymorphisms at the 5' end of the IGF1 gene with breast cancer risk, particularly among women younger than 55 years, and a strong association of polymorphisms located in the 5' end of IGFBP3 with circulating levels of IGFBP-3, which confirms previous findings. Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians.en
dc.format.extent286954 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titlePolymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.en
dc.typeArticleen
dc.format.digYES-

Related articles on PubMed

All Items in WARP are protected by copyright, with all rights reserved, unless otherwise indicated.