Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.
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Authors
Canzian, FMcKay, J D
Cleveland, R J
Dossus, Laure
Biessy, Carine
Rinaldi, Sabina
Landi, S
Boillot, C
Monnier, S
Chajès, V
Clavel-Chapelon, Françoise
Téhard, B
Chang-Claude, J
Linseisen, Jakob
Lahmann, Petra H
Pischon, Tobias
Trichopoulos, Dimitrios
Trichopoulou, Antonia
Zilis, D
Palli, Domenico
Tumino, Rosario
Vineis, Paolo
Berrino, Franco
Bueno-de-Mesquita, H Bas
Gils, C H van
Peeters, Petra H M
Pera, Guillem
Ardanaz, Eva
Chirlaque, María-Dolores
Quirós, José Ramón
Larrañaga, Nerea
Martínez-García, Carmen
Allen, Naomi E
Key, Timothy J
Bingham, Sheila A
Khaw, Kay-Tee
Slimani, N
Norat, Teresa
Riboli, Elio
Kaaks, Rudolf
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ArticleLanguage
en
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Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.Publiekssamenvatting
Insulin-like growth factor I (IGF-I) stimulates cell proliferation and can enhance the development of tumours in different organs. Epidemiological studies have shown that an elevated level of circulating IGF-I is associated with increased risk of breast cancer, as well as of other cancers. Most of circulating IGF-I is bound to an acid-labile subunit and to one of six insulin-like growth factor binding proteins (IGFBPs), among which the most important are IGFBP-3 and IGFBP-1. Polymorphisms of the IGF1 gene and of genes encoding for the major IGF-I carriers may predict circulating levels of IGF-I and have an impact on cancer risk. We tested this hypothesis with a case-control study of 807 breast cancer patients and 1588 matched control subjects, nested within the European Prospective Investigation into Cancer and Nutrition. We genotyped 23 common single nucleotide polymorphisms in IGF1, IGFBP1, IGFBP3 and IGFALS, and measured serum levels of IGF-I and IGFBP-3 in samples of cases and controls. We found a weak but significant association of polymorphisms at the 5' end of the IGF1 gene with breast cancer risk, particularly among women younger than 55 years, and a strong association of polymorphisms located in the 5' end of IGFBP3 with circulating levels of IGFBP-3, which confirms previous findings. Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians.PMID
16404426ae974a485f413a2113503eed53cd6c53
10.1038/sj.bjc.6602936
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