Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains.

2.50
Hdl Handle:
http://hdl.handle.net/10029/7189
Title:
Distribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains.
Authors:
Sabat, Artur; Melles, Damian C; Martirosian, Gayane; Grundmann, Hajo; Belkum, Alex van; Hryniewicz, Waleria
Abstract:
The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative, sdrE-negative gene profile was exclusive to methicillin-sensitive S. aureus (MSSA) strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and methicillin-resistant S. aureus strains (P < 0.0001). Our findings suggest that MSSA strains with the newly uncovered sdrC-positive, sdrD-negative, sdrE-negative gene profile have a substantially decreased potential to establish bone infection.
Citation:
J. Clin. Microbiol. 2006, 44(3):1135-8
Issue Date:
1-Mar-2006
URI:
http://hdl.handle.net/10029/7189
DOI:
10.1128/JCM.44.3.1135-1138.2006
PubMed ID:
16517913
Type:
Article
Language:
en
ISSN:
0095-1137
Appears in Collections:
Infectious Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorSabat, Artur-
dc.contributor.authorMelles, Damian C-
dc.contributor.authorMartirosian, Gayane-
dc.contributor.authorGrundmann, Hajo-
dc.contributor.authorBelkum, Alex van-
dc.contributor.authorHryniewicz, Waleria-
dc.date.accessioned2007-01-10T12:58:26Z-
dc.date.available2007-01-10T12:58:26Z-
dc.date.issued2006-03-01-
dc.identifier.citationJ. Clin. Microbiol. 2006, 44(3):1135-8en
dc.identifier.issn0095-1137-
dc.identifier.pmid16517913-
dc.identifier.doi10.1128/JCM.44.3.1135-1138.2006-
dc.identifier.urihttp://hdl.handle.net/10029/7189-
dc.description.abstractThe sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative, sdrE-negative gene profile was exclusive to methicillin-sensitive S. aureus (MSSA) strains (Fisher's exact test; P = 0.0005) and was not found in the strains collected from bone infections (P = 0.0019). We also found a strong association between the presence of the sdrD gene and methicillin-resistant S. aureus strains (P < 0.0001). Our findings suggest that MSSA strains with the newly uncovered sdrC-positive, sdrD-negative, sdrE-negative gene profile have a substantially decreased potential to establish bone infection.en
dc.format.extent90429 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleDistribution of the serine-aspartate repeat protein-encoding sdr genes among nasal-carriage and invasive Staphylococcus aureus strains.en
dc.typeArticleen
dc.format.digYES-

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